A5100363601- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Retinal Development and Disorders
- Anesthesia and Neurotoxicity Research
- Pluripotent Stem Cells Research
- Nerve injury and regeneration
- Peptidase Inhibition and Analysis
- Auditing, Earnings Management, Governance
- Tissue Engineering and Regenerative Medicine
- Corporate Finance and Governance
- Cardiac Fibrosis and Remodeling
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Financial Markets and Investment Strategies
- Alzheimer's disease research and treatments
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Hedgehog Signaling Pathway Studies
- Retinal Diseases and Treatments
- Sleep and Wakefulness Research
Xi'an Jiaotong University
2016-2025
Changchun University of Technology
2024
Guangdong University of Technology
2024
Institute of Neurobiology
2021
Fudan University Shanghai Cancer Center
2021
California University of Pennsylvania
2019
University of Pennsylvania
2019
Philadelphia University
2019
Northwest A&F University
2018
Beijing University of Technology
2018
Gastric cancer (GC) is one of the most common cancers, with high incidences in East Asia. microRNAs (miRNAs) play essential roles carcinogenesis GC. miR-20a was elevated GC, while potential function poorly understood. expression examined GC tissues and cell lines. The effects on growth, migration, invasion, chemoresistance cells were examined. Luciferase reporter assay Western blot used to screen target miR-20a. increased promoted migration invasion cells, enhanced cisplatin docetaxel....
Transmissible gastroenteritis virus (TGEV) infection can activate NF-κB pathway in porcine intestinal epithelial cells and result severe inflammation. Non-coding RNAs (ncRNAs) are not translated into proteins play an important role many biological pathological processes such as inflammation, viral infection, mitochondrial damage. However, whether ncRNAs participate TGEV-induced inflammation is largely unknown.In this study, the next-generation sequencing (NGS) technology was used to analyze...
Abstract This study examines the association between corporate social responsibility (CSR) performance and financial statement comparability. We use a sample of 7,462 firm‐year observations from firms listed on China's stock exchanges 2007 to 2016 find that some extent, with more positive CSR exhibit higher comparability, supporting notion managers have ethical concerns for stakeholder engagement. By contrast, inferior adverse significantly much lower Results are robust alternative variable...
Neural stem cells (NSCs) persist in the subgranular zone (SGZ) throughout lifespan and hold immense potential for repair regeneration of central nervous system, including hippocampal-related diseases. Several studies have demonstrated that cellular communication network protein 3 (CCN3) regulates multiple types cells. However, role CCN3 NSCs remains unknown. In this study, we identified expression mouse hippocampal observed supplementing improved cell viability a concentration-dependent...
Promoting both endogenous and exogenous neural stem cells' (NSCs) survival in the hostile host environments is essential to cell replacement therapy for central nervous system (CNS) disorders. Type 4 metabotropic glutamate receptor (mGluR4), one of members mGluRs, has been shown protect neurons from acute chronic excitotoxic insults various brain damages. The present study investigated preventive effects mGluR4 on NSC injury induced by oxidative stress. Under challenge with H2O2, loss...
Cell-cell interaction as one of the niche signals plays an important role in balance stem cell quiescence and proliferation or differentiation. In order to address effect possible mechanisms cell-cell connection on neural stem/progenitor cells (NSCs/NPCs) differentiation, upon passaging, NSCs/NPCs were either dissociated into single usual (named Group I) mechanically triturated a mixture small clusters containing direct connections II). Then biological behaviors including differentiation...
Abstract KDM4C is implicated in the regulation of cell proliferation, differentiation, and maintenance various stem types. However, its function neural cells (NSCs) remains poorly understood. Therefore, this study aims to investigate role regulatory mechanism NSCs. Primary hippocampal NSCs were isolated from neonatal mice, both vivo vitro lentivirus‐mediated overexpression induced these Staining results revealed a significant increase BrdU‐ Ki‐67‐positive cells, along with an elevated number...
Abstract. Earthquake is a major natural disaster triggered by the accumulation and release of crustal stress, accurate extraction pre-seismic anomaly signals crucial to improve earthquake prediction capability. In this study, an detection method for borehole strain data based on combination Segmented Variational Modal Decomposition (SVMD) Informer network proposed, study carried out 2021 Mado Ms7.4 in Qinghai. The SVMD effectively solves memory limitation problem traditional (VMD) when...
Glioblastoma multiforme (GBM) is the most lethal glioma variant in adult brain and among deadliest of human cancers. Increasing evidence has shown that metabotropic glutamate receptor subtype 4 (mGluR4) expression may play roles regulating growth neural stem cells as well several cancer cell lines. Here, we investigated effects mGluR4 on apoptosis LN229 GBM line. Involvement Gli-1, one key transcription factors sonic Hedgehog (SHH) signaling pathway, was further explored. In this study,...
Abstract Bladder cancer, the second most common genitourinary malignancy, severely endangers human health. Rising evidence suggests that metabotropic glutamate receptors (mGluRs) are involve in tumor progression. In this study, we observed receptor 4 (mGluR4) was functionally expressed normal and cancerous bladder cells its expression positively correlated with high cancer grading. We further confirmed activation of mGluR4 by VU0155041, an mGluR4‐specific agonist, decreased cyclic adenosine...
Abstract Glioblastoma stem cells (GSCs) exert a crucial influence on glioblastoma (GBM) development, progression, resistance to therapy, and recurrence, making them an attractive target for drug discovery. UTX, histone H3K27 demethylase, participates in regulating multiple cancer types. However, its functional role GSCs remains insufficiently explored. This study aims investigate the regulatory mechanism of UTX GSCs. Analysis TCGA data revealed heightened expression glioma, inversely...
Abstract Neural stem/progenitor cells (NSPCs) persist in the mammalian brain throughout life and can be activated response to physiological pathophysiological stimuli. Epigenetic reprogramming of NPSC represents a novel strategy for enhancing intrinsic potential regenerate after injury. Therefore, defining epigenetic features NSPCs is important developing therapies targeted rescue neurologic function In this study, we aimed at different subtypes by individual histone methylations. We found...
Abstract Neural stem/progenitor cells (NSPCs) persist in the mammalian subventricular zone throughout life, where they can be activated response to physiological and pathophysiological stimuli. A recent study indicates metabotropic glutamate receptor 4 (mGluR4) is involved regulating NSPCs behaviors. Therefore, defining mGluR4 function necessary for determining novel strategies enhance intrinsic potential brain regeneration after injuries. In this study, was functionally expressed...
Worldwide, neovascular age‑related macular degeneration (nAMD) is one of the most common causes blindness in elderly. In particular, retinal pigment epithelial (RPE) cells represents main pathological process development nAMD, and oxidative stress serves a major role. The present study aimed to investigate association between bone morphogenetic protein 6 (BMP‑6) nAMD. BMP‑6 concentration was significantly reduced patients with wet nAMD compared control group. Furthermore, investigated...
Anticancer metallodrugs that aim to physiological characters unique tumor microenvironment are expected combat drug tolerance and side-effects. Recently, owing the fact reactive oxygen species’ is closely related development of tumors, people committed developing with capacity improving level species toinduce oxidative stress in cancer cells. Herein, we demonstrated peptide templated gold clusters atomic precision preferably catalyze transformation hydrogen peroxide into superoxide anion...
Thin-layer SiO<sub>x</sub> matrix anchored nickel catalysts with high specific surface area and a unique electronic/geometric structure were fabricated for efficient CO<sub>2</sub> methanation.