A5100362277- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Ferroptosis and cancer prognosis
- Muscle Physiology and Disorders
- Extracellular vesicles in disease
- Hemoglobinopathies and Related Disorders
- Cancer, Lipids, and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Lung Cancer Treatments and Mutations
- Nanoparticle-Based Drug Delivery
- Metabolomics and Mass Spectrometry Studies
- Alkaloids: synthesis and pharmacology
- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- Gut microbiota and health
- Advanced Nanomaterials in Catalysis
- Iron Metabolism and Disorders
Nankai University
2023-2025
Yancheng First People's Hospital
2025
Xuzhou Medical College
2025
Nantong University
2022-2025
China Jiliang University
2025
Guangzhou University of Chinese Medicine
2024-2025
First Affiliated Hospital of Jinan University
2024
Qingdao Agricultural University
2024
Nanjing Normal University
2022-2023
Sun Yat-sen University
2008-2023
Myocardial infarction (MI) is a severe disease that often associated with dysfunction of angiogenesis. Cell-based therapies for MI using mesenchymal stem cell (MSC)-derived exosomes have been well studied due to their strong proangiogenic effect. Genetic modification one the most common methods enhance exosome therapy. This study investigated and cardioprotective effect derived from hypoxia-inducible factor 1-alpha (HIF-1α)-modified MSCs.Lentivirus containing HIF-1α overexpressing vector was...
Abstract Fluorescence lifetime imaging provides more possibility of in vivo multiplexing second near infrared (NIR‐II) window. However, it still faces the obstacle that fluorescent probes with differentiable often exhibit quite different fluorescence intensity, especially short usually accompanies a weak resulting difficulty for simultaneously decoding multiplexed information due to interference background noise. To facilitate high‐fidelity imaging, we developed series Er 3+ doped double...
Abstract The prognosis of renal cell carcinoma (RCC) remains poor due to metastases and resistance chemotherapy. Salinomycin (Sal) exhibits the potential antitumor, while underlying mechanism is not completely clear. Here, we found that Sal induced ferroptosis in RCCs identified Protein Disulfide Isomerase Family A Member 4 (PDIA4) as a mediator Sal’s effect on ferroptosis. suppressed PDIA4 by increasing its autophagic degradation. Downregulation increased sensitivity ferroptosis, ectopic...
Acetylation of p53 at carboxyl-terminal lysine residues enhances its transcriptional activity associated with cell cycle arrest and apoptosis. Here we demonstrate that acetylation Lys-320/Lys-373/Lys-382 is also required for transcription-independent functions in BAX activation, reactive oxygen species production, apoptosis response to the histone deacetylase inhibitors (HDACi) suberoylanilide hydroxamic acid LAQ824. Knock-out markedly reduced HDACi-induced Unexpectedly, expression...
Helicobacter pylori (H. pylori) is one of the most important factors that affect development gastric cancer, and its mechanism remains un-elucidated. Our present study found that, miR-30a crucial for regulating growth migration H. infected cancer in vitro by targeting COX-2 BCL9. In details, double-stranded precursor produced two single-stranded matured miRNAs including miR-30a-3p miR-30a-5p, which played significant biological functions different manners. First, inhibited expression...
Responsive drug release in tumor mitochondria is a pre-requisite for mitochondria-targeted delivery systems to improve the efficacy of this promising therapeutic modality. To end, photothermal stimulation strategy mitochondria-responsive along with heat shock developed maximize antitumor effects minimal side effects. Methods: This relies on mitochondrial-targeted doxorubicin (DOX) through and lipophilic agent IR-780 iodide (IR780)-modified glycolipid conjugates (CSOSA), which can...
Gold nanoplates exhibit 68.5% photothermal conversion efficiency and peroxidase-like activity, AuNPTs (50 μg mL<sup>−1</sup>)/H<sub>2</sub>O<sub>2</sub> (0.1 mM)/NIR (1 W cm<sup>−2</sup>, 3 min) show excellent synergistic antibacterial ability promote MRSA-infected wound healing <italic>in vivo</italic>.
In recent years, nicotinamide adenine dinucleotide (NAD
The p53 tumor suppressor induces cell growth arrest and apoptosis in response to DNA damage. Because these functions are achieved largely by the transcriptional properties of p53, nuclear localization protein is essential. Indeed, tumors with aberrant cytoplasmic wild-type often exhibit an impaired In this study, we report that Thr-55 phosphorylation association export factor CRM1, leading export. We further show MDM2 also promotes CRM1-p53 required for process. Interestingly, inhibition a...
Abstract Introduction Age is an important factor in the development of osteoarthritis. Microarray studies provide insight into cartilage aging but do not reveal full transcriptomic phenotype chondrocytes such as small noncoding RNAs, pseudogenes, and microRNAs. RNA-Seq a powerful technique for interrogation large numbers transcripts including nonprotein coding RNAs. The aim study was to characterise molecular mechanisms associated with age-related changes gene signatures. Methods RNA...
Our previous study demonstrated that aldolase A (ALDOA) is overexpressed in clinical human lung squamous cell carcinoma and ALDOA promotes epithelial-mesenchymal transition tumorigenesis. The present aimed to explore the function of modulation non-small cancer (NSCLC) proliferation cycle progression potential mechanism.ALDOA was knocked down by short hairpin RNA H520 H1299 cells. with vectors carrying full-length sequence H157 capacities were assessed immunohistochemical staining, Cell...
Background Breast cancer is the most common worldwide. Hypoxia and lactate metabolism are hallmarks of cancer. This study aimed to construct a novel hypoxia- metabolism-related gene signature predict survival, immune microenvironment, treatment response breast patients. Methods RNA-seq clinical data from The Cancer Genome Atlas database Gene Expression Omnibus were downloaded. Hypoxia- genes collected publicly available sources. differentially expressed identified using “edgeR” R package....
Earlier studies have demonstrated a functional link between B56gamma-specific protein phosphatase 2A (B56gamma-PP2A) and p53 tumor suppressor activity. Upon DNA damage, complex including B56gamma-PP2A is formed which leads to Thr55 dephosphorylation of p53, induction the transcriptional target p21, inhibition cell proliferation. Although an enhanced interaction B56gamma observed after underlying mechanism its significance in PP2A tumor-suppressive function remain unclear. In this study, we...
Climate change is predicted to be a serious threat agriculture due the need for crops able tolerate increased heat stress. Desert plants have already adapted high levels of stress so they make excellent systems identifying genes involved in thermotolerance. Rhazya stricta an evergreen shrub that native extremely hot regions across Western and South Asia, making it system examining plant responses Transcriptomes apical mature leaves R. were analyzed at different temperatures during several...