A5102026067- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- HIV Research and Treatment
- interferon and immune responses
- Tuberculosis Research and Epidemiology
- Mosquito-borne diseases and control
- Cytomegalovirus and herpesvirus research
- Ubiquitin and proteasome pathways
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Virus-based gene therapy research
- RNA modifications and cancer
- HIV/AIDS drug development and treatment
- RNA regulation and disease
- Viral Infections and Vectors
- HIV/AIDS Research and Interventions
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Virology and Viral Diseases
- Geomechanics and Mining Engineering
Soochow University
2016-2025
Shaanxi Normal University
2010-2023
Soochow University
2022
Shenyang Institute of Computing Technology (China)
2021
Chinese Academy of Sciences
2021
University of Chinese Academy of Sciences
2021
Institute of Infection and Immunity
2013-2014
Liaoning Technical University
2001-2011
University of Houston
2011
Yale Cancer Center
2010
Autophagy is a cytoplasmic degradative pathway that can participate in biosynthetic processes, as the yeast Cvt pathway, but more commonly known for its functions removing damaged or surplus organelles and macromolecular complexes. Here, we find autophagy intersects with human immunodeficiency virus (HIV) biogenesis, mirroring above dichotomy. Early, nondegradative stages of promoted HIV yields. Gag-derived proteins colocalized interacted factor LC3, productive Gag processing. Nevertheless,...
Bone marrow stromal cell antigen 2 (BST-2) is a restriction factor for human immunodeficiency virus type I (HIV-1) and plays an important role in regulating the release of viral particles. However, antiviral efficacy BST-2 antagonized by HIV-1-encoded accessory protein Vpu, which facilitates degradation recruiting E3 ubiquitin ligase β-TrCP. The involvement deubiquitinases (DUBs) counteracting ubiquitination influencing its stability during HIV-1 infection remains inadequately explored. In...
The autophagic clearance of mitochondria has been defined as mitophagy, which is triggered by mitochondrial damage and serves a major pathway for homeostasis cellular quality control. PINK1 Parkin-mediated mitophagy the most extensively studied form linked to pathogenesis neurodegenerative disorders, including Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis. current paradigm this particular that ubiquitination outer membrane key step enable recognition damaged core component...
Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC) is characterized by immune cell infiltration and myocardial damage. High mobility group box 1 (HMGB1) a highly conserved nuclear DNA-binding protein that participates in DNA replication, transcriptional regulation, repair response inflammatory different disease models. To investigate the exact function of HMGB1 CVB3-induced VMC, we crossed Hmgb1-floxed (Hmgb1f/f ) mice with carrying suitable Cre recombinase transgenic strain to achieve...
ABSTRACT Dendritic cells (DCs) transmit human immunodeficiency virus type 1 (HIV-1) to CD4 + T through the trans - and cis -infection pathways; however, little is known about relative efficiencies of these pathways whether they are interdependent. Here we compare -infections HIV-1 mediated by immature DCs (iDCs) mature (mDCs), using replication-competent single-cycle HIV-1. Monocyte-derived iDCs were differentiated into various types mDCs lipopolysaccharide (LPS), tumor necrosis factor alpha...
Monocytes are critical precursors of dendritic cells and macrophages, which play an important role in the pathogenesis human immunodeficiency virus type 1 (HIV-1). HIV-1 postentry infection is blocked undifferentiated monocytes vitro, while underlying mechanisms not fully understood. Tat-mediated transactivation viral long terminal repeat (LTR) promoter essential for transcription. Two cellular cofactors Tat, cyclin T1 (CycT1) cyclin-dependent kinase 9 (CDK9), required LTR-directed In...
The participation of microRNAs (miRNAs) in cardiovascular diseases suggests them as potential targets for novel preventive and therapeutic strategies. In this study, the key myocardial miRNA, miR-21, was identified murine coxsackievirus B3 (CVB3)-induced myocarditis model its contribution to disease progression explored.Myocardial microRNA expression changes CVB3-infected mice were analyzed by real-time PCR miR-21 found be miRNA whose significantly reduced. Mice injected with plasmid...
The Internet of Things (IoT) is helpful in making people's life more convenient and efficient. To ensure that the nodes within IoT can interact securely, a certificateless signature (CLS) be used to protect message authentication IoT. Recently, some concrete constructions CLS schemes have been proposed literature, but through our analyses, we demonstrate existing cannot keep their claimed security because various flaws. For example, valid forged by any Type I adversary replacing...
Secreted acid phosphatase (SapM) is an immunomodulator of
Loss-of-function studies in human embryonic stem cells (hESCs) and induced pluripotent (iPSCs) via nonviral approaches have been largely unsuccessful. Here we report a simple cost-effective method for high-efficiency delivery of plasmids siRNAs into hESCs iPSCs. Using this siRNA delivery, achieve >90% reduction the expression cell factors Oct4 Lin28, observe morphological staining pattern changes, characteristics hESC differentiation, as result knockdown.
In cancer, the extracellular matrix is extensively remodeled during chronic inflammation, thus affecting cell transcription, differentiation, migration and cell-cell interactions. Matrix metalloproteinases can degrade of tumor tissues take important roles in disease progression. Numerous efforts to develop cancer treatments targeting have failed clinical trials owing ineffectiveness toxicity applied inhibitors. this study, we investigated potential oncolytic virus combination therapy. We...
Early-life respiratory viral infections are linked to subsequent development of allergic asthma in children. We assessed the underlying immunological mechanisms a novel model induction phase childhood asthma. BALB/c mice were infected neonatally with pneumonia virus mice, then sensitized intranasally ovalbumin following recovery. Animals challenged low levels aerosolized for 4 weeks induce changes chronic asthma, received single moderate-level challenge elicit mild acute inflammation. To...
Abstract Deubiquitinating enzymes (DUBs) are cysteine proteases that reverse the ubiquitination by removing ubiquitins from target protein. The human genome encodes ∼100 potential DUBs, which can be classified into six families, influencing multiple cellular processes, such as antiviral responses, inflammatory apoptosis, etc. To systematically explore role of DUBs involved in immunity, we performed an RNA interference–based screening contains 97 DUBs. We identified ubiquitin-specific...