A5014894920- Viral Infections and Immunology Research
- interferon and immune responses
- Antimicrobial Peptides and Activities
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- NF-κB Signaling Pathways
- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Tuberculosis Research and Epidemiology
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Cytokine Signaling Pathways and Interactions
- Mosquito-borne diseases and control
- Hepatitis C virus research
- Bone Metabolism and Diseases
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Mycobacterium research and diagnosis
Soochow University
2016-2025
Fudan University
2005-2025
Obstetrics and Gynecology Hospital of Fudan University
2025
Xuzhou Medical College
2024
First Affiliated Hospital of Soochow University
2024
First Affiliated Hospital of Jinan University
2024
Shanghai Jiao Tong University
2022
Fujian University of Traditional Chinese Medicine
2020-2022
Huashan Hospital
2022
Taizhou Central Hospital
2022
Background and Aims: Monocarboxylate transporter (MCT) 4 is a high‐affinity lactate that primarily involved in the maintenance of intracellular pH homeostasis highly expressed different tumors. However, role MCT4 modulating immune responses against HCC remains unknown. Approach Results: In this study, we demonstrated was overexpressed HCC, which associated with poor prognosis patients. Genetic or pharmacological inhibition using VB124 (a potent inhibitor) suppressed tumor growth...
Background Apart from triggering host immune responses, macrophages also act as a major reservoir for mycobacteria. For better survival, mycobacteria have evolved various mechanisms to modulate the production of proinflammatory cytokines in macrophages, and manipulation micro-RNA (miRNA) expression has been considered an important one. Methodology/Principal Findings In this study, we found that miR-146a was significantly increased time- dose-dependent manner mycobacteria-infected...
Anti-dsDNA Ab is reported to be the central pathogenic autoantibody involved in systemic lupus erythematosus (SLE) pathogenesis. However, mechanisms anti-dsDNA production remain unclear. Recent evidence indicated that DNA-containing immune complexes (ICs) circulation (termed "circulating ICs"), which are one of hallmarks SLE, might production. In this study, we explored their potential role and underlying patients with SLE. We demonstrated circulating ICs were able induce Ab. Of note, HMGB1...
Induction of specific humoral and cellular immunity in the lung airways is proposed to be critical for vaccine protection against Mycobacterium tuberculosis (M. tb). To facilitate airway delivery antigen targeting presenting cells alveoli, we employed mannosylated chitosan (MCS) formulate a multi-T-epitope DNA vaccine, pPES, as an intranasal TB vaccine. MCS -DNA nanoparticles appeared spherical with average particle sizes 400 nm. HSP65-specific bronchoalveolar lavage fluid SIgA level was...
Tripartite motif-containing 21 (TRIM21) is a regulator of tissue inflammation and pro-inflammatory cytokine production, has been implicated in negative regulation ofIRF3-dependent type I interferon signaling. However, the antiviral activity TRIM21 varies among diverse viruses its role on remains inconsistent different microbial infections. Here, we investigate potential for controlling Coxsackievirus B3 (CVB3) replication susceptible organ pathology. We found that CVB3 infection up-regulated...
Abstract Background To investigate the effect of lactic acid (LA) on progression bone metastasis from colorectal cancer (CRC) and its regulatory effects primary CD115 (+) osteoclast (OC) precursors. Methods The BrdU assay, Annexin-V/PI TRAP staining immunofluorescence were performed to explore LA proliferation, apoptosis differentiation OC precursors in vitro vivo. Flow cytometry was sort CD4(+) T cells analyze change expression target proteins A recruitment assay used test how Cadhein-11...
Cathelicidin antimicrobial peptides (mouse, CRAMP; human, LL-37) have broad-spectrum antiviral activities against enveloped viruses, but their mechanisms of action nonenveloped viruses remain to be elucidated. Coxsackievirus B3 (CVB3), a member virus belonging the Enterovirus genus Picornaviridae, is an important pathogen viral myocarditis and dilated cardiomyopathy. Here, we observed that cardiac CRAMP expression was significantly upregulated in mice after CVB3 infection. The administration...
Abstract Background The regulatory role of N6-methyladenosine (m6A) modification in the onset and progression cancer has garnered increasing attention recent years. However, specific m6A pulmonary metastasis colorectal remains unclear. Methods This study identified differential gene expression between primary its metastases using transcriptome sequencing immunohistochemistry. We investigated biological function METTL3 both vitro vivo assays such as CCK-8, colony formation, wound healing,...
Objectives. Systemic lupus erythematosus (SLE) is characterized by serological presence of anti-double-stranded DNA (dsDNA) antibodies and its pathogenesis remains unclarified. Our previous work found that syngeneic activated lymphocyte-derived (ALD-DNA) induced SLE-like autoimmune disease in the SLE-non-prone BALB/c mice. Here, biological chemical characteristics somatic were focused upon to investigate their contribution autoimmunity induction provide clues for understanding SLE...
Cardiac fibrogenesis in the late stage of viral myocarditis causing contractile dysfunction and ventricular dilatation, is a major pathogenic factor for progression to serious cardiovascular diseases including dilated cardiomyopathy (DCM) congestive heart failure (HF). Recent studies indicate that regulatory T cells (Tregs) are involved fibrotic process liver lung fibosis. However, role Tregs development myocarditis-caused cardiac fibrosis their therapeutic potential remains...
DNA-dependent activator of interferon-regulatory factors (DAI) functions as a cytoplasmic DNA sensor that activates the innate immune system. We previously found activated lymphocyte-derived self-apoptotic (ALD-DNA) immunization led to pathological macrophage activation and M2b polarization, which could initiate propagate murine lupus nephritis. However, specific sensor(s) well underlying molecular mechanisms involved in ALD-DNA-induced polarization systemic erythematosus (SLE) disease...
Background/Purpose . HMGB1, which may act as a proinflammatory mediator, has been proposed to contribute the pathogenesis of multiple chronic inflammatory and autoimmune diseases including systemic lupus erythematosus (SLE); however, precise mechanism HMGB1 in pathogenic process SLE remains obscure. Method The expression was measured by ELISA western blot. also applied detect cytokines levels. Furthermore, nephritic pathology evaluated H&E staining renal tissues. Results In this study,...
Background Viral myocarditis, which is most prevalently caused by Coxsackievirus B3 (CVB3) infection, a serious clinical condition characterized cardiac inflammation. However, efficient therapies targeting inflammation are still lacking and much needed. A20, also known as tumor necrosis factor alpha induced protein 3 (TNFAIP3) key negative regulator of But whether A20 may affect during acute viral myocarditis remains to be elucidated. The aim this study was investigate the potential...
Wound healing-promoting peptides exhibit excellent therapeutic potential in regenerative medicine. However, amphibian-derived wound and their mechanism of action remain to be further elucidated. We hereby characterized a novel peptide, Ot-WHP, derived from Chinese concave-eared frog Odorrana tormota. It efficiently promoted healing mouse model full-thickness wounds. Ot-WHP significantly increased the number neutrophils wounds, modestly neutrophil phagocytosis phorbol myristate acetate...
Abstract Cancer cells are addicted to glutamine. However, cancer often suffer from glutamine starvation, which largely results the fast growth of and insufficient vascularization in interior tissues. Herein, based on clinical samples, patient‐derived (PDCs), cell lines, it is found that liver display stem‐like characteristics upon shortage due maintaining stemness tumor initiating (TICs) even promoting transformation non‐TICs into by starvation. Increased expression synthetase (GS) essential...
The roles of bactericidal cathelicidins against bacterial infection have been extensively studied. However, the antibacterial property and mechanism action non-bactericidal are rarely known. Herein, a novel naturally occurring cathelicidin ( Popu CATH) from tree frog Polypedates puerensis ) did not show any direct anti-bacterial activity in vitro. Intriguingly, intraperitoneal injection CATH before inoculation significantly reduced load frogs mice, inflammatory response induced by mice....