A5100434998- Medical and Agricultural Research Studies
- Healthcare Systems and Public Health
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- Acoustic Wave Phenomena Research
- Metamaterials and Metasurfaces Applications
- Takotsubo Cardiomyopathy and Associated Phenomena
- Animal Virus Infections Studies
- Retinal Imaging and Analysis
- Optical Coherence Tomography Applications
- Microbial Natural Products and Biosynthesis
- Mosquito-borne diseases and control
- Reproductive Biology and Fertility
- Autophagy in Disease and Therapy
- Fungal Biology and Applications
- COVID-19 Impact on Reproduction
- Parathyroid Disorders and Treatments
- Management of metastatic bone disease
- Pneumocystis jirovecii pneumonia detection and treatment
- Alkaline Phosphatase Research Studies
- Chromatin Remodeling and Cancer
- Peripheral Artery Disease Management
- Inflammasome and immune disorders
- Drug-Induced Ocular Toxicity
- Phytoestrogen effects and research
Sichuan University
2025
Tianjin University of Science and Technology
2020-2025
Soochow University
2019-2025
Nanjing Medical University
2021-2025
Hebei Medical University
2024
Sun Yat-sen University
2021-2024
Army Medical University
2019-2023
Shanghai Jiao Tong University
2023
The Seventh Affiliated Hospital of Sun Yat-sen University
2022
Institute of Microbiology
2015-2021
The interaction between gastric epithelium and immune response plays key roles in H. pylori-associated pathology. We demonstrated a procolonization proinflammation role of MMP-10 pylori infection. is elevated mucosa produced by epithelial cells synergistically induced IL-22 via the ERK pathway. Human was correlated with colonization severity gastritis, mouse from non-BM-derived promoted bacteria inflammation. inflammation were attenuated IL-22-/-, MMP-10-/-, IL-22-/-MMP-10-/- mice....
As a large enveloped RNA virus, coronavirus is of considerable medical and veterinary significance, anticoronavirus treatment challenging due to its biodiversity rapid variability. In this study, Au@Ag nanorods (Au@AgNRs) were successfully synthesized by coating AuNRs with silver shown for the first time have activity against replication porcine epidemic diarrhea virus (PEDV). Viral titer analysis demonstrated that Au@AgNRs could inhibit PEDV infection 4 orders magnitude at 12 h...
Abstract Background Spinal cord injury (SCI) is a serious clinical condition that has pathological changes such as increased neuroinflammation and nerve tissue damage, which eventually manifests fibrosis of the injured segment development spinal cavity leading to loss function. Cell-based therapy, mesenchymal stem cells (MSCs) neural (NSCs) are promising treatment strategies for via immunological regulation replacement respectively. However, therapeutic efficacy rare reported on combined...
Phomanolides A (1) and B (2), unique meroterpenoids with new pentacyclic tetracyclic skeletons, respectively, phomanoxide (3), the double-epoxidation product of a putative biosynthetic precursor 1 2, were isolated from solid substrate fermentation cultures fungus Phoma sp., along known compound eupenifeldin (4). The structures 1–3 elucidated based on NMR spectroscopic data electronic circular dichroism calculations further secured by X-ray crystallography. Biogenetically, compounds 2 could...
Several studies show that media opacity reduces vessel density (VD) measured by image processing algorithms of optical coherence tomography angiography (OCTA). However, different models OCTA designed their own and computational methods, which may have effects on VD. This study is aimed to investigate the impact a simulated model quantitative measurement two devices.A spectral-domain based (Cirrus 5000; Carl Zeiss Meditec) swept-source (Triton DRI-OCT, Topcon Inc.) were used retinal...
Fluorescence sensing is widely used in vitro detection due to its high sensitivity and rapid result delivery. However, systems based on nanomaterials involving complex cumbersome purification steps can lead sample loss significantly reduce the accuracy of results. To address this issue, we proposed a lanthanide-based aptasensor featuring target-triggered antenna effect enhance time-resolved luminescence (TRL) chelated Tb3+ combined with wash-free strategy. This sensor enabled highly...
Abstract Red yeast rice (RYR), fermented from Monascus purpureus , has demonstrated anti‐inflammatory, anticancer, antibacterial properties, and potential antiviral activity. However, its low water solubility hampers broader application. With the growing interest in carbon dots (CDs) for research, efforts to create new CDs that are highly compatible with living organisms have strong properties been sped up. In this study, hydrothermal approach was employed synthesize biocompatible...
Optical coherence tomography angiography (OCTA) provides not only visualisation but also quantitative measurement of foveal avascular zone (FAZ). Media opacity is common in elderly subjects with cataracts. This study aimed to investigate the impact media on automated and manual FAZ measurement.Cirrus 5000 OCTA Triton were used image using a 3×3 mm scanning protocol from 30 eyes healthy normal subjects. was simulated neutral-density filters (optical density (OD): 0.10-0.48 Cirrus 0.15-0.51...
The ability of Mycobacterium tuberculosis (M. tb) to survive and persist in the host for decades an asymptomatic state is important aspect pathogenesis. Although adaptation hypoxia thought play a prominent role underlying M. tb persistence, how bacteria achieve this goal largely unknown. Rv0081, member DosR regulon, induced at early stage while Rv3334 one enduring hypoxic response genes. In study, we uncovered genetic interactions between these two transcription factors. RNA-seq analysis...
Dengue virus (DENV) is the most important vector-borne globally. The safe and effective vaccines are still under development there no antiviral drugs for DENV induced diseases. In this study, we obtained five DENV1 isolates (DENV1 A to E) from outbreak of dengue fever in 2014 Guangzhou, China, analyzed their replication efficiency virulence vitro vivo. results suggested that among strains, B has highest both human mosquito cells vitro, also causes mortality suckling mice. Further study...
Background: Heel blood sampling of newborns plays an important role in the diagnosis neonatal hypothyroidism, phenylketonuria, and other inherited metabolic diseases. Embracing breast milk sucking (EBMS) can increase newborn's sense security relieve pain. The purpose present study was to explore effect EBMS on alleviating pain heel sampling.Methods: A total 96 neonates undergoing screening were selected from June 2019 2020, randomly divided into 2 groups (n=48 each group). control group...
Cardiac damage induced by ischemic stroke, such as arrhythmia, cardiac dysfunction, and even arrest, is referred to cerebral-cardiac syndrome (CCS). macrophages are reported be closely associated with stroke-induced damage. However, the role of macrophage subsets in CCS still unclear due their heterogeneity. Sympathetic nerves play a significant regulating cardiovascular disease. sympathetic unclear.
Ischemic stroke remains a devastating disease which is the leading cause of death worldwide. Visual impairment after common complication may lead to vision loss, greatly impacting life quality patients. While ischemic traditionally characterized by blockage blood flow brain, this coincide with reduced eye, resulting in retinal ischemia and visual impairment. Diabetes increases risk induces diabetic retinopathy; latter be more sensitive injury. In status, underlying mechanism stroke-induced...
We present the first example that a single fungal HR-PKS could synthesize multiple complicated compounds.
Dry eye disease (DED) is a multifactorial with high prevalence worldwide. Uncomfortable corneal sensations severely affect daily life in DED patients. Hence, neuron injury vital pathogenesis DED. Notably, endoplasmic reticulum stress (ERS) plays role peripheral injury. However, the of ERS still far from being clear. In this study, we established an environmental (eDED) model vivo and hyperosmotic vitro . Subsequently, trigeminal ganglion (TG) neurons were retrograde labeled by WGA-Alexa...
Neuropathy and chloracne induced by 3,5,6-trichloropyridin-2-ol sodium: Report of three cases
Summary The immunomodulatory cellular network that triggers early inflammation and demyelination, the key steps in multiple sclerosis (MS) pathogenesis remains poorly characterized. Here, we demonstrate overactivation of Wnt pathway promotes pathological transformation oligodendrocyte precursor cells (OPCs) to replicate OPCs human MS. In mouse experimental autoimmune encephalomyelitis (EAE), attract CD4 + T-helper 1 (Th1) into spinal cord brain through CC-chemokine ligand 4 (CCL4), whilst...