A5081377631- Micro and Nano Robotics
- Nanoplatforms for cancer theranostics
- Electrospun Nanofibers in Biomedical Applications
- Molecular Communication and Nanonetworks
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- Electrochemical sensors and biosensors
- Nanoparticle-Based Drug Delivery
- Conducting polymers and applications
- Advanced Nanomaterials in Catalysis
- Electrochemical Analysis and Applications
- Microfluidic and Bio-sensing Technologies
- Analytical Chemistry and Sensors
- Retinal Development and Disorders
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Coronary Interventions and Diagnostics
- Biosensors and Analytical Detection
- Surface Modification and Superhydrophobicity
- Advanced Sensor and Energy Harvesting Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Heavy Metal Exposure and Toxicity
- Bone Tissue Engineering Materials
- Genetic and Kidney Cyst Diseases
- Nanomaterials for catalytic reactions
Nanjing Normal University
2016-2025
Institute of Molecular Functional Materials
2025
Nanjing Drum Tower Hospital
2021-2024
Tianjin University of Technology
2024
Guizhou University
2022-2024
Hubei University of Arts and Science
2019-2023
Xiangyang Central Hospital
2022-2023
Southwest Petroleum University
2018-2020
North University of China
2013
Shanghai Jiao Tong University
2012
Current chemical-fuel-driven nanomotors are driven by gas (e.g. H2, O2, NH3) which only provides motion ability, and can produce waste Mg(OH)2, Pt). Here, inspired endogenous biochemical reactions in the human body involving conversion of amino acid L-arginine to nitric oxide (NO) NO synthase (NOS) or reactive oxygen species (ROS), we report on a nanomotor made hyperbranched polyamide/L-arginine (HLA). The utilizes as fuel for production both driving force provide beneficial effects,...
The treatment difficulties of venous thrombosis include short half-life, low utilization, and poor penetration drugs at thrombus site. Here, we develop one kind mesoporous/macroporous silica/platinum nanomotors with platelet membrane (PM) modification (MMNM/PM) for sequentially targeting delivery thrombolytic anticoagulant treatment. Regulated by the special proteins on PM, target site then PM can be ruptured under near-infrared (NIR) irradiation to achieve desirable sequential drug release,...
Poor permeation of therapeutic agents and multidrug resistance (MDR) in solid tumors are the two major challenges that lead to failure current chemotherapy methods. Herein, a zero-waste doxorubicin-loaded heparin/folic acid/l-arginine (HFLA-DOX) nanomotor with motion ability sustained release nitric oxide (NO) achieve deep drug penetration effective reversal MDR cancer is designed. The targeted recognition, blood vessels, intercellular penetration, special intracellular distribution...
The microneedle (MN) provides a promising strategy for transdermal delivery of exosomes (EXO), in which the therapeutic effects and clinical applications are greatly reduced by fact that EXO can only partially reach injury site passive diffusion. Here, we designed detachable MN array to deliver modified nitric oxide nanomotor (EXO/MBA) Achilles tendinopathy (AT) healing. With releasing EXO/MBA, l-arginine was converted NOS or ROS as driving force. Benefiting from motion ability property MPC...
Abstract Destruction of tumor metabolism symbiosis is an attractive cancer treatment method which targets cells with little harm to normal cells. Yet, a single intervention strategy and poor penetration the drug in tissue result limited effect. Herein, we propose zero‐waste zwitterion‐based hydrogen sulfide (H 2 S)‐driven nanomotor based on basic principle reaction human body. When loaded monocarboxylic acid transporter inhibitor α‐cyano‐4‐hydroxycinnamic (α‐CHCA), can move microenvironment...
Abstract The major challenges of immunotherapy for glioblastoma are that drugs cannot target tumor sites accurately and properly activate complex immune responses. Herein, we design prepare a kind chemotactic nanomotor loaded with brain endothelial cell targeting agent angiopep-2 anti-tumor drug (Lonidamine modified mitochondrial triphenylphosphine, TLND). Reactive oxygen species inducible nitric oxide synthase (ROS/iNOS), which specifically highly expressed in microenvironment, used as...
The first examples of boronic acid-linked fluorescent and colorimetric chemosensors for copper ions are reported; the monoboronic acid-conjugated rhodamine probe displays a highly selective enhancement with Cu2+ among various metal whereas fluorescence bisboronic fluorescein is selectively quenched by Cu2+, probably way PET mechanism.
Polycaprolactone (PCL) has been widely adopted as a scaffold biomaterial, but further improvement of the hemocompatibility PCL film surface is still needed for wide biomedical applications. In this work, was functionalized with zwitterionic poly(3-dimethyl(methacryloyloxyethyl) ammonium propane sulfonate) (P(DMAPS)) brushes via surface-initiated atom transfer radical polymerization (ATRP) enhancing hemocompatibility. Kinetics study revealed an approximately linear increase in graft yield...
Biodegradable core/shell structured poly(L-lactide) acid (PLLA)/chitosan (CS) nanofibers were fabricated by coaxial electrospinning. PLLA and CS dissolved in dichloromethane aqueous acetic solvents for spinning into core shell layers, respectively. of high molecular weight was difficult to spin electrospinning due its viscosity, but it easier achieve with PLLA. The preparation conditions optimized changing the ratios PLLA/CS under different jet voltages. After being investigated scanning...
The ability of nanomotors to promote the deep penetration themselves and loaded drugs in diseased tissues has been proposed confirmed. However, whether such motion behavior can also micrometer-sized immune cells microenvironment, which is important for immunotherapy some diseases, not mentioned. Herein, we construct a nitric oxide (NO)-driven nanomotor that move tumor focusing on its role NO, beneficial product released during movement from this kind nanomotor, regulating infiltration...
A nanorobot is used to realize deep penetration of drugs in atherosclerotic plaque, photothermal ablation inflammatory macrophages and long-term anti-proliferation effects.
Inducing autophagy of macrophages to improve abnormal lipid metabolism is an important way treat atherosclerosis (AS). Yet, the current application mammalian target rapamycin (mTOR)-dependent inducers limited by side effects and lack targeting low biological availability. Herein, a kind nitric oxide (NO)-driven carrier-free nanomotor based on reaction between trehalose (Tr, one mTOR-independent inducers), L-arginine (Arg), phosphatidylserine (PS) reported. The developed nanomotors use NO as...
Current exosome engineering methods usually lead to the damage of morphology and membrane, which cannot meet complex needs disease treatment. Herein, concept an "independent module/cascading function" is proposed construct engineered nanotherapy platform including independent artificial module a natural module. The with movement/chemotaxis function first synthesized, then it controllably combined "one by one" mode through "differentiated" modification method. whole process can not only...
Recombinant granulocyte colony-stimulating factor (G-CSF), with a direct repair effect on injured cardiomyocytes against myocardial infarction ischemia-reperfusion-injury (IRI), displays poor owing to the limited cardiac targeting efficacy. There are almost no reports of nanomaterials that deliver G-CSF IRI site. Herein, we propose way protect by constructing one layer nitric oxide (NO)/hydrogen sulfide (H2S) nanomotors its outside. NO/H2S specific chemotactic ability high expression...
Pathological features of liver fibrosis, clinical treatment and application therapeutic nanoagents for fibrosis.
The designability and high reactivity of nanotechnology provide strategies for antitumor therapy by regulating the redox state in tumor cells. Here, we synthesize a kind vanadium dioxide nanoparticle encapsulated bovine serum albumin containing disulfide bonds (VSB NPs) photothermal-enhanced ferroptosis pyroptosis effects. Mechanism studies show that can effectively consume overexpressed glutathione (GSH) microenvironment, leading to decrease peroxidase 4 (GPX4) activity. Simultaneously,...