A5047904644- Ultrasound and Hyperthermia Applications
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Spinal Cord Injury Research
- Ultrasound and Cavitation Phenomena
- Cancer-related molecular mechanisms research
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Pancreatitis Pathology and Treatment
- Tuberous Sclerosis Complex Research
- Eosinophilic Disorders and Syndromes
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal cell carcinoma treatment
- IgG4-Related and Inflammatory Diseases
- Immune cells in cancer
- COVID-19 and healthcare impacts
- Spinal Dysraphism and Malformations
- RNA modifications and cancer
- Nerve injury and regeneration
- Hematological disorders and diagnostics
- Gastrointestinal disorders and treatments
Second Affiliated Hospital of Xi'an Jiaotong University
2021-2023
First Affiliated Hospital of Zhengzhou University
2016-2020
Shaanxi Normal University
2007-2009
Shanxi Normal University
2009
Breast cancer (BC) is the most diagnosed in women. Cuproptosis new regulated cell death, distinct from known death mechanisms and dependent on copper mitochondrial respiration. However, comprehensive relationship between cuproptosis BC still blank until now. In present study, we acquired 13 cuproptosis-related regulators (CRRs) previous research downloaded RNA sequencing data of TCGA-BRCA UCSC XENA database. The CRRs were all differently expressed normal samples. Using consensus clustering...
Abstract In contemporary literature, little attention has been paid to the association between coronavirus disease‐2019 (COVID‐19) and cancer risk. We performed Mendelian randomization (MR) investigate causal associations three types of COVID‐19 exposures (critically ill COVID‐19, hospitalized respiratory syndrome 2 (SARS‐CoV‐2) infection) 33 different cancers European population. The results inverse‐variance‐weighted model indicated that genetic liabilities critically had suggestive with...
Aberrantly expressed microRNAs (miRNAs) after spinal cord injury (SCI) participate in diverse biological pathways and processes, including apoptosis, inflammation, oxidative stress responses, peroxidation, ferroptosis. This study was aimed at exploring the mechanisms underlying miRNA-mediated ferroptosis an SCI rat model. In present study, a T10 weight-dropping model established miRNA profiling used to detect expression profiles post-SCI. Basso-Beattie-Bresnahan scores inclined plane test,...
Lithium is associated with oxidative stress and apoptosis, but the mechanism by which lithium protects against spinal cord injury remains poorly understood. In this study, we found that intraperitoneal administration of chloride (LiCl) in a rat model alleviated pathological inhibited expression tumor necrosis factor α, interleukin-6, interleukin 1 β. pyroptosis reduced inflammation inhibiting Caspase-1 expression, reducing response, activation Nod-like receptor protein 3 inflammasome. We...
Background Breast cancer is the most common worldwide. Hypoxia and lactate metabolism are hallmarks of cancer. This study aimed to construct a novel hypoxia- metabolism-related gene signature predict survival, immune microenvironment, treatment response breast patients. Methods RNA-seq clinical data from The Cancer Genome Atlas database Gene Expression Omnibus were downloaded. Hypoxia- genes collected publicly available sources. differentially expressed identified using “edgeR” R package....
Persistent inflammation in the secondary spinal cord injury (SCI) is an important reason for failure of nerve repair, which partly due to continuous activation local M1-like macrophage/microglia. It reported that extracellular trap (ET) has been a new way cell death, can be released by macrophages and named macrophage (Met). Furthermore, it exists widely pathophysiological process many diseases, but rarely studied field SCI. In this study, we constructed contusion model assessed function...
<i>Background:</i> The aim of this study was to investigate the mechanism underlying bioeffects low-intensity continuous ultrasound on isolated sarcoma 180 (S180) cells and cellular responses these effects. <i>Methods:</i> After sonication, several structural functional parameters were examined elucidate ultrasound-induced cell damage. <i>Results:</i> Instant disruption membrane might be caused by acoustic cavitation, producing mechanical chemical effects...
Purpose: The biologic effects and the underlying mechanisms of Ehrlich ascitic tumor (EAT) cells induced by ultrasound were investigated in this study. Methods: Cells subjected to ultrasonic irradiation with a frequency 2.17 MHz an intensity 3 W/cm2 for variable periods time. Trypan blue exclusion was used detect integrity cellular membrane; membrane permeability incorporation fluorescein isothiocyanate dextran during exposure; cell ultrastructure changes observed under scanning electron...
Abstract Background: Breast cancer (BC) has the highest incidence rate of all cancers globally, with high heterogeneity. Increasing evidence shows that lactate and long non-coding RNA (lncRNA) play a critical role in occurrence, maintenance, therapeutic response, immune microenvironment tumors. We aimed to construct lactate-related lncRNAs prognostic signature (LRLPS) for BC patients predict prognosis, tumor microenvironment, treatment responses. Methods: The data was download from Cancer...
Breast cancer (BC) has the highest incidence rate of all cancers globally, with high heterogeneity. Increasing evidence shows that lactate and long non-coding RNA (lncRNA) play a critical role in tumor occurrence, maintenance, therapeutic response, immune microenvironment. We aimed to construct lactate-related lncRNAs prognostic signature (LRLPS) for BC patients predict prognosis, microenvironment, treatment responses. The data download from Cancer Genome Atlas (TCGA) database was entire...
Objective: To explore the diagnosis and treatment of head neck Castleman's disease (CD), to improve understanding disease. Methods: The clinical data 41 patients with CD treated from January 2007 July 2017 in First Affiliated Hospital Zhengzhou University were analyzed retrospectively. divided into two groups: localized (LCD, n=27) multicentric (MCD, n=14). manifestations, laboratory examinations, operations, pathological findings follow-up analyzed. Results: LCD was characterized by...
Objective To study the relationship between preoperative systemic immune inflammatory index (SII) and prognosis of postoperative patients. Methods A retrospective analysis was made on 1 509 patients with gastric cancer who underwent surgery at Department Gastrointestinal Surgery, Affiliated Tumor Hospital Harbin Medical University from Jan 1991 to Dec 2012. The SII values [SII = (platelets x neutrophils) / lymphocytes] were calculated grouped according mean. clinical factors...
Objective To study the damage focused ultrasound inflicts on membrane permeability of Ehrlich ascitic tumor (EAC) cells and relationship between changes in ultra-sound exposure time. Methods The relative survival rate was examined at various intensities dif-ferent times using 2.2 MHz ultrasound. uhrastructure were evaluated with a scanning electron microscope after different exposures. Membrane investigated by incorporating fluorescein isothiocyanate dextran (FD5OO) , measuring lactate...
回顾性分析29例胸部Castleman病临床资料。单中心型多无症状；CT平扫表现为均匀低密度，增强后动脉期明显强化，可见点状或分枝状钙化；病理以透明血管型为主，手术治疗效果好。多中心型可出现发热、胸闷；CT增强扫描低至中度均匀强化，周边强化明显；需综合治疗，预后差。
回顾性分析2015年1月至2018年12月郑州大学第一附属医院病理确诊的9例肝血管周上皮细胞肿瘤(PEComa)患者，对其临床诊疗和预后进行分析。患者随访5.0～51.0个月，1例患者穿刺活检未进一步治疗，出院后6个月因肾脏肿瘤破裂死亡，另8例手术切除患者未发现肿瘤复发及转移。肝PEComa以女性多发，临床症状不典型，可伴腹痛、腹胀不适、食欲减退、发热、体重减轻。肝PEComa常单发，以肝右叶多见。术前完善影像学检查可协助诊断，CT平扫肿瘤呈均匀低密度或不均匀混杂密度，增强扫描动脉期表现为明显不均匀强化。肝PEComa以手术切除为主，良性首选手术治疗且预后良好，恶性需综合治疗。