A5085777018- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Nanocluster Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Molecular Sensors and Ion Detection
- Photonic Crystals and Applications
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Extraction and Separation Processes
- Photonic and Optical Devices
- Telomeres, Telomerase, and Senescence
- Membrane Separation Technologies
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Photocatalysis Techniques
- Dietary Effects on Health
- Biosensors and Analytical Detection
- Advancements in Battery Materials
- Mitochondrial Function and Pathology
- Metal Extraction and Bioleaching
- Photosynthetic Processes and Mechanisms
- Infrastructure Maintenance and Monitoring
- Advanced materials and composites
- Nonlinear Optical Materials Studies
- Traditional Chinese Medicine Analysis
Weifang People's Hospital
2017-2025
Binzhou University
2024-2025
Binzhou Medical University
2024-2025
Westlake University
2024-2025
Shanghai Jiao Tong University
2005-2025
Zhejiang Sci-Tech University
2023-2025
Union Hospital
2024-2025
Jilin University
2025
Institute for the Future
2025
Institute of Natural Science
2025
Bile salt hydrolase plays an important role in bile acid-mediated signaling pathways, which regulate lipid absorption, glucose metabolism, and energy homeostasis. Several reports suggest that changes the composition of acids are found many diseases caused by dysbacteriosis. Here, we present taxonomic identification (BSH) human microbiota elucidate abundance activity differences various bacterial BSH among 11 different populations from six continents. For first time, revealed protein...
Metabolic syndrome (MetS) is intricately linked to dysregulation of gut microbiota and host metabolomes. Here, we first find that a purified citrus polymethoxyflavone-rich extract (PMFE) potently ameliorates high-fat diet (HFD)-induced MetS, alleviates dysbiosis, regulates branched-chain amino acid (BCAA) metabolism using 16S rDNA amplicon sequencing metabolomic profiling. The metabolic protective effects PMFE are dependent, as demonstrated by antibiotic treatment fecal microbiome...
Nanozymes are artificial enzymes, which can substitute traditional biological enzymes for multifield applications. However, to date, it remains challenging search novel mimic or multienzyme mimics. Herein, a facile and green method preparing monodisperse, homogeneous copper nanoclusters (Cu NCs) with smaller size was developed, used cysteamine as template hydrazine hydrate reductant reduce Cu2+. The as-prepared Cu NCs exhibited excellent tetraenzyme-like activities, including peroxidase...
Microbial trimethylamine (TMA)-lyase activity promotes the development of atherosclerosis by generating TMA, precursor TMA N-oxide (TMAO). TMAO is well documented, but same can not be said TMA-producing bacteria. This work aimed to identify genera in human intestinal microbiota. We retrieved genomes human-associated microorganisms from Human Microbiome Project database comprising 1751 genomes, Unified Gastrointestinal Genome collection consisting 4644 gut prokaryotes, recapitulated 4930...
Astrocytes activation in response to stroke results altered mitochondrial exchange with neurons. Ginsenoside Rb1is a major ginsenoside of Panax ginseng particularly known for its neuroprotective potential. This work aimed investigate if Rb1 could rescue neurons from ischemic insult via astrocyte inactivation and transfer. We prepared conditioned astrocytes-derived medium co-culture examined the role transfer astrocytes The potential was further confirmed vivo using mouse model brain...
Background: As new biomarkers of coronary artery diseases (CAD) emerge via metabolomics, the underlying functional mechanisms remain to be elucidated. Functional metabolomics aims translate metabolomics-derived disease mechanisms. Methods: A cohort 2324 patients who underwent angiography from 4 independent centers was studied. combination ultra–performance liquid chromatography and quadrupole time-of-flight mass spectrometry in negative ion mode used for untargeted analysis metabolites...
It is important to detect pathogens rapidly, sensitively, and selectively for clinical medicine, homeland security, food safety, environmental control. We report here a specific sensitive colorimetric assay that incorporated bovine serum albumin-templated Co3O4 magnetic nanozyme (Co3O4 MNE) with novel fusion phage protein magnetophoretic chromatography Staphylococcus aureus. The MNE was conjugated S. aureus-specific fusion-pVIII MNE@fusion-pVIII), screened from the AQTFLGEQD (the monoclone...
Silver nanoclusters (AgNCs) were first coated with bovine serum albumin (BSA) and then encapsulated into porous metal–organic frameworks of ZIF-8 by the protein-mediated biomineralization process. Unexpectedly, fluorescence intensities yielded AgNCs-BSA@ZIF-8 nanocomposites discovered to be continuously enhanced during each BSA coating encapsulation steps. Compared common AgNCs, greatly improved photostability storage stability AgNCs could also expected. More importantly, having benefited...
Abstract Disordered hepatic glucagon response contributes to hyperglycemia in diabetes. The regulators involved are less understood. This work aims investigate the roles of mitochondrial β-oxidation enzyme HADHA and its downstream ketone bodies response. Here we show that challenge impairs expression HADHA. Liver-specific overexpression reversed gluconeogenesis mice, while knockdown augmented Stable isotope tracing shows promotes body production via β-oxidation. β-hydroxybutyrate (BHB) but...
Conditional survival (CS) analysis can estimate further probabilities based on the time already survived, providing dynamic updates for prognostic information. This study aimed to develop a CS-nomogram promote individualized disease management stage III non-small cell lung cancer (NSCLC). included patients diagnosed with NSCLC in Surveillance, Epidemiology, and End Results database from 2010 2017 (N = 3,512). The CS was calculated as CS(y|x) OS(y + x)/OS(x), where x) OS(x) were overall (OS)...
Amphipathic polymer pullulan acetate (PA)-coated magnetic nanoparticles were prepared and characterized by various physicochemical means. The cytotoxicity cellular uptake of the examined. hyperthermic effect on tumor cells was evaluated. Transmission electron microscopy (TEM) showed that PA coated (PAMNs) had spherical morphology. Dynamic light scattering (DLS) size distribution PAMNs unimodal,with an average diameter 25.8 nm ± 6.1 nm. presence adsorbed layer magnetite surface confirmed...
As metabolomics is widely used in the study of disease mechanisms, an increasing number studies have found that metabolites play important role occurrence diseases. The aim this to investigate effects and mechanisms quercetin high-fat-sucrose diet (HFD)-induced nonalcoholic fatty liver (NAFLD) development using nontargeted metabolomics. A rat model NAFLD was established by feeding with HFD for 30 50 days. results indicated exhibited hepatoprotective activity 30-day HFD-induced rats...
Gold nanoplates exhibit 68.5% photothermal conversion efficiency and peroxidase-like activity, AuNPTs (50 μg mL<sup>−1</sup>)/H<sub>2</sub>O<sub>2</sub> (0.1 mM)/NIR (1 W cm<sup>−2</sup>, 3 min) show excellent synergistic antibacterial ability promote MRSA-infected wound healing <italic>in vivo</italic>.
Despite considerable therapeutic advances, there is still a dearth of evidence on the molecular determinants cardiac hypertrophy that culminate in heart failure. Neuraminidases are family enzymes catalyze cleavage terminal sialic acids from glycoproteins or glycolipids. This study sought to characterize role neuraminidases pathological and identify pharmacological inhibitors targeting mammalian neuraminidases.Neuraminidase 1 (NEU1) was highly expressed hypertrophic hearts mice rats, this...
Background Conditional survival (CS) is defined as the possibility of further after patients have survived for several years since diagnosis. This may be highly valuable real-time prognostic monitoring, especially when considering individualized factors. Such prediction tools were lacking non-metastatic triple-negative breast cancer (TNBC). Therefore, this study estimated CS and developed a novel CS-nomogram 10-year survival. Methods We recruited 32,836 TNBC from Surveillance, Epidemiology,...