A5004358890- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Neuroscience and Music Perception
- Mental Health Research Topics
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Obsessive-Compulsive Spectrum Disorders
- Neurological disorders and treatments
- Fungal Infections and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Treatment of Major Depression
- Intracranial Aneurysms: Treatment and Complications
- Management of metastatic bone disease
- Hormonal Regulation and Hypertension
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Stress Responses and Cortisol
- MRI in cancer diagnosis
- Adrenal and Paraganglionic Tumors
- Pulmonary Hypertension Research and Treatments
- EEG and Brain-Computer Interfaces
- Ear and Head Tumors
- Neural and Behavioral Psychology Studies
First Affiliated Hospital of Zhengzhou University
2015-2025
Shanghai Jiao Tong University
2025
Eye & ENT Hospital of Fudan University
2025
High Magnetic Field Laboratory
2024
Zhengzhou University
2015
Multifaceted evidence has shown that psychiatric disorders share common neurobiological mechanisms. However, the tremendous inter-individual heterogeneity among patients with limits trans-diagnostic studies case-control designs, aimed at identifying clinically promising neuroimaging biomarkers. This study aims to identify neuroanatomical differential factors (ND factors) underlying gray matter volume variations in five disorders. We leverage 4 independent datasets of 878 diagnosed and 585...
Decreased serum ferritin level was recently found in schizophrenia. Whether the brain iron concentration schizophrenia exists abnormality is of research significance. Quantitative susceptibility mapping (QSM) used this study to assess changes grey matter nuclei patients with first-episode The local ethics committee approved study, and all subjects gave written informed consent. Thirty 30 age gender-matched healthy controls were included study. QSM effective transverse relaxation rate (R2*)...
Abstract Background Mental disorders, including depression, obsessive compulsive disorder (OCD), and schizophrenia, share a common neuropathy of disturbed large-scale coordinated brain maturation. However, high-interindividual heterogeneity hinders the identification shared distinct patterns network abnormalities across mental disorders. This study aimed to identify altered structural covariance Methods Subject-level aberrance in patients with disorders was investigated using individualized...
Background and objective The pathogenesis of schizophrenia (SCH) is related to the dysfunction monoamine neurotransmitters, habenula participates in regulating synthesis release dopamine. We examined static functional connectivity (sFC) dynamic (dFC) first-episode patients using resting state magnetic resonance imaging (rs-fMRI) this study. Methods A total 198 first-Episode, drug-Naïve 199 healthy controls (HC) underwent rs-fMRI examinations. sFC dFC analysis with as seed was performed...
Background 4D flow MRI shows great potential in neurovascular disorders such as stenosis, atherosclerotic disease, aneurysms, and vascular malformations. Its widespread application the system requires evidence of good test–retest multicenter reproducibility. Purpose To assess reproducibility, reliability interobserver dependence measurements cerebral blood flow/velocity main intracranial vessels. Study Type Prospective study. Subjects Ten healthy subjects underwent scans at three different...
Studies have reported that white matter hyperintensities (WMHs) are associated with disturbances in immune function, and the relationship between WMHs cognitive impairments been documented various clinical populations. The present study was to examine WMHs, patients schizophrenia (SCH) remains unknown. A sample of 127 drug-naïve first episode SCH 72 healthy controls (HCs) were included this study. Serum levels cytokines oxidative stress indices measured using enzyme-linked immunosorbent...
ABSTRACT Objective One of the primary challenges in surgical procedures involving parapharyngeal space (PPS) lesions is accurately localizing internal carotid artery (ICA) within space. This study aims to investigate anatomical landmarks (ppICA) endoscopic transoral approach surgery. Methods A total seven fresh frozen cadaveric heads (14 sides) were dissected using medial pterygomandibular fold laboratory Surgical Treatment Technology Innovation Unit at Nasal Skull Base Tumor Eye and ENT...
The cortico-hippocampal network is an emerging neural framework with striking evidence that it supports cognition in humans, especially memory; this includes the anterior temporal (AT) system, posterior medial (PM) hippocampus (aHIPPO), and (pHIPPO). This study aimed to detect aberrant patterns of functional connectivity within between large-scale networks first-episode schizophrenia patients compared a healthy control group via resting-state magnetic resonance imaging (rs-fMRI) explore...
Aim The aim of this study was to assess the whole‐brain dynamic functional connectivity first‐episode and treatment‐naive patients with obsessive–compulsive disorder (OCD) investigate clinical correlations abnormal changes in connectivity. Methods Twenty‐nine our hospital diagnosed OCD 29 healthy controls matched for age, sex, education were included study. Resting‐state magnetic resonance imaging scans performed on a 3.0‐Tesla scanner hospital. Three temporal metrics state expression...
Abstract Numerous studies indicate altered static local and long‐range functional connectivity of multiple brain regions in schizophrenia patients with auditory verbal hallucinations (AVHs). However, the temporal dynamics interhemispheric intrahemispheric patterns remain unknown AVHs. We analyzed resting‐state magnetic resonance imaging data for drug‐naïve first‐episode patients, 50 AVHs without AVH (NAVH), age‐ sex‐matched healthy controls. Whole‐brain was decomposed into ipsilateral...
The thalamus is known to be impaired in schizophrenia patients with auditory verbal hallucinations (AVHs). Abnormal filtering function of the has been found AVHs. However, a whole-structure approach commonly adopted when investigating thalamic dysconnectivity AVHs, and it remains unclear which nucleus critical structure underlying Here, we investigated voxel-wise resting-state functional connectivity (rsFC) drug-naïve first-episode (FES) In addition, dynamic causal modeling was applied...
Auditory verbal hallucinations (AVHs) are a major symptom of schizophrenia and connected with impairments in auditory speech-related networks. In AVHs, alterations resting-state cerebral blood flow (CBF) functional connectivity have been described. However, the neurovascular coupling specific to first-episode drug-naïve (FES) patients AVHs remain unknown.
This study aimed to determine whether a combined diagnosis of whole-lesion histogram analysis T1- and T2-weighted imaging based on support vector machine (SVM) can distinguish pheochromocytoma from adrenal adenoma.A pathology database was retrospectively appraised over period 7 years we obtained 40 histopathologically proven adenomas 20 pheochromocytomas with magnetic resonance images. The T1-weighted (T1WI, including both in phase opposed phase) (T2WI) images each patients were analyzed...
Objective: To investigate the abnormal changes of static functional connectivity (sFC) and dynamic (dFC) in dopaminergic midbrain (ventral dorsal tegmental area bilateral substantia nigra compacta, VTA/SNc) patients with first-episode schizophrenia(SCH), their correlation Positive Negative Symptom Scale (PANSS). Methods: The data 198 untreated schizophrenia 199 healthy controls (HC) matched by age, sex years education who were admitted to First Affiliated Hospital Zhengzhou University from...
Abstract Aim The purpose of our study was to analyze the clinical and imaging features uterine carcinosarcoma (UCS) cervical (CCS), explore diagnostic staging accuracy computed tomography (CT) magnetic resonance (MRI) examinations. Methods 41 patients including 37 with UCS 4 CCS from July 2011 September 2020 were enrolled in study. Of cases, 7 had CT images, 27 MRI 3 both images. Clinical data, or findings analyzed. Diagnosis images also Results Carcinosarcoma usually occurs postmenopausal...
Background and objective Peak width of skeletonized mean diffusivity (PSMD), a fully automated diffusion tensor imaging (DTI) biomarker white matter (WM) microstructure damage, has been shown to be associated with cognition in various WM pathologies. However, its application schizophrenic disease remains unexplored. This study aims investigate PSMD along other DTI markers first-episode schizophrenia patients compared healthy controls (HCs), explore the correlations between these metrics...
As a key feature of schizophrenia, auditory verbal hallucination (AVH) is causing concern. Altered dynamic functional connectivity (dFC) patterns involving in related regions were rarely reported schizophrenia patients with AVH. The goal this research was to find out the dFC abnormalities first-episode, drug-naïve and without AVH using resting state magnetic resonance imaging (rs-fMRI).A total 107 AVH, 85 (NAVH) underwent rs-fMRI examinations, 104 healthy controls (HC) matched. Seed-based...