A5051422040- Nanoplatforms for cancer theranostics
- Advanced Fiber Laser Technologies
- RNA Interference and Gene Delivery
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Advanced Nanomaterials in Catalysis
- Immunotherapy and Immune Responses
- Antimicrobial agents and applications
- Nanoparticle-Based Drug Delivery
- Photonic and Optical Devices
- Advanced biosensing and bioanalysis techniques
- Particle physics theoretical and experimental studies
- Luminescence and Fluorescent Materials
- HIV Research and Treatment
- Immune Response and Inflammation
- Supramolecular Self-Assembly in Materials
- Hydrogels: synthesis, properties, applications
- Photonic Crystal and Fiber Optics
- Advanced Drug Delivery Systems
- Neutrino Physics Research
- Virus-based gene therapy research
- Advanced Photonic Communication Systems
- Plasmonic and Surface Plasmon Research
- Nanocluster Synthesis and Applications
- Ion-surface interactions and analysis
Wenzhou Medical University
2022-2025
First Affiliated Hospital of Wenzhou Medical University
2022-2025
University of Chinese Academy of Sciences
2021-2025
Nankai University
2016-2025
State Key Laboratory of Medicinal Chemical Biology
2015-2025
The Fifth People’s Hospital of Suzhou
2025
Shanghai First People's Hospital
2004-2025
Affiliated Hospital of Southwest Medical University
2025
Shanghai Jiao Tong University
2012-2025
Jinzhou Medical University
2025
Biofilms cause persistent bacterial infections and are extremely recalcitrant to antimicrobials, due in part reduced penetration of antimicrobials into biofilms that allows bacteria residing the depth a biofilm survive antimicrobial treatment. Here, we describe preparation surface-adaptive, Triclosan-loaded micellar nanocarriers showing (1) enhanced accumulation, (2) electrostatic targeting at acidic pH toward negatively charged cell surfaces biofilm, (3) release degradation micelle core by...
Increasing bacterial drug resistance to antibiotics has posed a major threat contemporary public health, which resulted in large number of people suffering from serious infections and ending up dying without any effective therapies every year. Here, dynamic covalent polymeric antimicrobial, based on phenylboronic acid (PBA)-installed micellar nanocarriers incorporating clinical vancomycin curcumin, is developed overcome drug-resistant infections. The formation this antimicrobial facilitated...
Abstract Due to the emergence of drug resistance in bacteria and biofilm protection, achieving a satisfactory therapeutic effect for bacteria‐infected open wounds with conventional measures is problematic. Here, photothermal cascade nano‐reactor (CPNC@GOx‐Fe 2+ ) constructed through supramolecular strategy hydrogen bonding coordination interactions between chitosan‐modified palladium nano‐cube (CPNC), glucose oxidase (GOx), ferrous iron (Fe ). CPNC@GOx‐Fe exhibits excellent effects powers...
Abstract Diabetic foot ulcers infected with antibiotic‐resistant bacteria form a severe complication of diabetes. Antimicrobial‐loaded hydrogels are used as dressing for wounds, but the ongoing rise in number antimicrobial‐resistant infections necessitates new, nonantibiotic based designs. Here, guanosine‐quadruplex (G 4 )‐hydrogel composed guanosine, 2‐formylphenylboronic acid, and putrescine is designed cascade‐reaction container. The G ‐hydrogel loaded glucose‐oxidase hemin. first...
Designing an effective treatment strategy to combat oral diseases caused by complex polymicrobial biofilms remains a great challenge. Herein, series of metal-phenolic network with Pd nanoparticle nodes using polyphenols as stabilizers and reducing agents is constructed. Among them, sulfonated lignin-Pd (SLS-Pd) ultrafine size palladium nanoparticles broadband near infrared absorption exhibit excellent oxidase-like activity stable photothermal effect. In vitro experiments demonstrate that the...
Abstract To tackle the problems caused by bacterial biofilms, herein, this study reports an antimicrobial hybrid amphiphile (aHA) via dynamic covalent bonds for eradicating staphylococcal biofilms. aHA is synthesized iminoboronate ester formation between DETA NONOate (nitric oxide donor), 3 4‐dihydroxybenaldehyde, and phenylboronic acid‐modified ciprofloxacin (Cip). can self‐assemble in aqueous solution with ultra‐small critical aggregation concentration of 3.80 × 10 –5 m high drug loading...
To address the issue posed by drug-resistant bacteria and inspired natural antimicrobial enzymes, we report atomically doped copper on guanine-derived nanosheets (G–Cu) that possess integrated catalytic cascade property of glucose oxidase peroxidase, yielding free radicals to eliminate upon light irradiation. Density functional theory calculations demonstrate could notably promote oxygen activation H2O2 splitting G–Cu complexes. Further all-atom simulation experimental data indicate lysis is...
The mucus layer and cell membrane are two major barriers against pulmonary siRNA delivery. Commonly used polycationic gene vectors can hardly penetrate the due to adsorption of mucin glycoproteins that trap destabilize polyplexes. Herein, guanidinated fluorinated bifunctional helical polypeptides were developed synchronizingly overcome these barriers. guanidine domain α-helix facilitated trans-membrane delivery into macrophages, whereas fluorination dramatically enhanced permeation...
Abstract Bacterial infections are mostly due to bacteria in their biofilm mode‐of‐growth, making them recalcitrant antibiotic penetration. In addition, the number of bacterial strains intrinsically resistant available antibiotics is alarmingly growing. This study reports that micellar nanocarriers with a poly(ethylene glycol) shell fully penetrate staphylococcal biofilms biological invisibility. However, when complemented poly(β‐amino ester), these mixed‐shell micelles become positively...
Zwitterionic micelles find their own path through the body to disperse an infectious biofilm and enhance antibiotic efficacy.
Stimuli-sensitive hydrogels are ideal candidates for biomedical and bioengineering purposes, although applications of may be limited, due in part to the limited choice suitable materials constructing hydrogels, complexity synthesis source materials, undesired fast-then-slow drug-release behaviors usual hydrogels. Herein, we describe fabrication a new supramolecular guanosine (G)-quadruplex hydrogel by multicomponent self-assembly endogenous (G), 2-formylboronic acid (2-FPBA),...
Strong Mn-Mn coupling interactions (dipole-dipole and spin-exchange), predominantly determined by statistically apparently short Mn···Mn distances in traditional heavily Mn2+-doped semiconductors, can promote energy transfer within randomly positioned close-knit Mn2+ pairs. However, the intrinsic mechanism on controlling emission efficiency is still elusive due to lack of precise structure information local tetrahedrally coordinated ions. Herein, a group Mn2+-containing metal-chalcogenide...
Carbon bridges: The title reaction has been successfully developed, and applied to the total synthesis of tetracyclic diterpenoids phyllocladanol phyllocladene. method provides an efficient, general, conceptually new strategy for construction structurally complex diverse [n.2.1] carbocyclic skeletons (see scheme). As a service our authors readers, this journal supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited...
Controlling excitation power is the most convenient approach to dynamically tuning upconversion that essential for a variety of studies. However, this suffers from significant constraint due insensitive response systems power. Here we present study amplifying power-sensitivity in Ho3+ ions through use NaYbF4 host. Mechanistic investigation reveals sensitive stems maximal incident energy enabled by concentrated Yb3+ sensitizers. This allows us sensitively tune red-to-green emission intensity...
Abstract Local hypoxia in tumors is an undesirable consequence of photodynamic therapy (PDT), which will lead to greatly reduced effectiveness this therapy. Bioreductive pro‐drugs that can be activated at low‐oxygen conditions highly cytotoxic under tumors. Based on principle, double silica‐shelled upconversion nanoparticles (UCNPs) nanostructure capable co‐delivering photosensitizer (PS) molecules and a bioreductive pro‐drug (tirapazamine, TPZ) were designed (TPZ‐UC/PS), with synergetic...
Internalization of Staphylococcus aureus by macrophages can inactivate bacterial killing mechanisms, allowing intracellular residence and dissemination infection. Concurrently, these staphylococci evade antibiotics that are frequently unable to pass mammalian cell membranes. A binary, amphiphilic conjugate composed triclosan ciprofloxacin is synthesized self-assemble through micelle formation into antimicrobial nanoparticles (ANPs). These novel ANPs stabilized encapsulation in macrophage...
A light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C–H bonds has been developed. High-value-added aromatic ketones carboxylic acids were easily prepared in high-to-excellent yields using readily available starting materials.
Glioblastoma (GBM) is a devastating primary brain tumor resistant to conventional therapies. A major obstacle GBM treatment the blood-brain barrier (BBB), or blood-glioma barrier, which prevents transport of systemically administered (chemotherapeutic) drugs into tumor. This study reports design dodecamer peptide (G23)-functionalized polydopamine (pD)-coated curcumin-loaded zein nanoparticles (CUR-ZpD-G23 NPs) that efficiently traversed BBB, and delivered curcumin glioblastoma cells. The NPs...