A5065805410- Cancer-related molecular mechanisms research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Circular RNAs in diseases
- Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Viral-associated cancers and disorders
- Autophagy in Disease and Therapy
- CNS Lymphoma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Metabolomics and Mass Spectrometry Studies
- Acute Lymphoblastic Leukemia research
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Imaging Techniques and Applications
- Molecular Biology Techniques and Applications
- T-cell and Retrovirus Studies
Zhejiang University
2022
Ministry of Education of the People's Republic of China
2022
Union Hospital
2019-2021
Huazhong University of Science and Technology
2019-2021
Northwest A&F University
2018-2019
Current studies have shown that long non-coding RNAs (lncRNAs) may serve as prognostic biomarkers in multiple cancers. Therefore, we postulated expression patterns of lncRNAs combined into a single signature could improve clinicopathological risk stratification and prediction overall survival rate for breast cancer patients. Two algorithms, Least Absolute Shrinkage Selector Operation (LASSO) Support Vector Machine-Recursive Feature Elimination (SVM-RFE), were used to select candidate...
The competing endogenous RNA (ceRNA) networks are an effective method for investigating cancer; however, construction of ceRNA among different subtypes breast cancer has not been previously performed. Based on analysis differentially expressed RNAs between 150 triple-negative (TNBC) tissues and 823 non-triple-negative (nTNBC) downloaded from TCGA database, a network was constructed based database comparisons using Cytoscape. Survival receiver operating characteristic (ROC) curve data were...
Transmissible gastroenteritis virus (TGEV) infection can activate NF-κB pathway in porcine intestinal epithelial cells and result severe inflammation. Non-coding RNAs (ncRNAs) are not translated into proteins play an important role many biological pathological processes such as inflammation, viral infection, mitochondrial damage. However, whether ncRNAs participate TGEV-induced inflammation is largely unknown.In this study, the next-generation sequencing (NGS) technology was used to analyze...
Transmissible gastroenteritis (TGE) is a contagious and infectious disease that characterized by severe vomiting diarrhea of swine , especially piglet, caused transmissible coronavirus (TGEV) .TGEV infection provokes mitochondrial damage porcine intestinal epthelial cell (IPEC), which responsible for inflammation death.In our previous study, we have demonstrated circular RNA circEZH2 was down-regulated during TGEV promoted the activation nuclear factor kappa-light-chain-enhancer activated B...
Immune checkpoint blockade (ICB), particularly programmed death 1 (PD-1) and its ligand (PD-L1), has shown considerable clinical benefits in patients with various cancers. Many studies show that PD-L1 expression may be biomarkers to help select responders for anti-PD-1 treatment. Therefore, it is necessary elucidate the molecular mechanisms control expression. As a potential chemosensitizer anticancer drug, disulfiram (DSF) kills tumor cells via regulating multiple signaling pathways...
Abstract Purpose The role of interim 18 F‐FDG PET/CT (iPET/CT) in diffuse large B‐cell lymphoma (DLBCL) remains controversial. purpose this study was to assess the prognostic value iPET/CT patients with newly diagnosed DLBCL according visual and semiquantitative interpretation methods. Methods A total 129 baseline data were retrospectively screened. findings evaluated by Deauville 5‐point scale (DS) ΔSUVmax. Furthermore, reduction SUVmax incorporated tumor size (ΔSUVmax*ΔSLD) calculated....
Transmissible gastroenteritis virus (TGEV) infection can cause acute inflammation. Long noncoding RNAs (lncRNAs) play important roles in a number of biological process including inflammation response. However, whether lncRNAs participate TGEV-induced porcine intestinal epithelial cells (IPECs) is largely unknown.In this study, the next-generation sequencing (NGS) technology was used to analyze profiles Mock and TGEV-infected cell-jejunum 2 (IPEC-J2) cell line. A total 106 were differentially...
Background: Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral (PTCL) that has a poor 5-year overall survival rate due to its lack precise therapeutic targets. Identifying potential prognostic markers AITL may provide information regarding the development precision medicine. Methods: RNA sequence data from PTCL and patient clinic traits were obtained Gene Expression Omnibus (GEO) database. Differentially expressed gene (DEG) analysis weighted co-expression...
Background: Both epithelial-to-mesenchymal transition (EMT) and cancer stem cells play important roles in development progression of breast cancer.MicroRNA (miR)-30 family members have been reported to be associated with the regulation EMT cell phenotypes, however, underlying molecular mechanisms are not well understood.Methods: miR-30a stable transfectants lines were created using a lentiviral system.Bioinformatics analysis was performed explore target genes SOX4 selected identified by dual...
Abstract In this study, our aim was to compare the efficacy and toxicity profiles of gemcitabine, cisplatin, dexamethasone (GDP) ifosfamide, carboplatin, etoposide (ICE) regimens in salvage treatment relapsed/refractory lymphoma. A total 110 patients with refractory/relapsed classical Hodgkin lymphoma (n = 22) or non-Hodgkin 88) who received GDP ICE from January 2011 July 2018 were retrospectively analyzed. Of patients, 50 GDP, 60 ICE. The response could be evaluated all patients. group, 30...
Abstract Background: Transmissible gastroenteritis virus (TGEV) infection can cause acute inflammation. Long noncoding RNAs (lncRNAs) play important roles in a number of biological process including inflammation response. However, whether lncRNAs participate TGEV-induced porcine intestinal epithelial cells (IPECs) is largely unknown. Results: In this study, the next-generation sequencing (NGS) technology was used to analyze profiles Mock and TGEV-infected cell-jejunum 2 (IPEC-J2) cell line....
Abstract Background: Transmissible gastroenteritis virus (TGEV) infection can activate the immune response and cause inflammation. Long noncoding RNAs (lncRNAs) play important roles in antiviral innate response. However, whether lncRNAs participate TGEV-induced inflammation porcine intestinal epithelial cells (IPECs) is largely unknown. Results: In this study, next-generation sequencing (NGS) technology was used to analyze profiles of Mock TGEV-infected cell-jejunum 2 (IPEC-J2) cell line. A...