A5059194721- interferon and immune responses
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- RNA Research and Splicing
- RNA regulation and disease
- Food Allergy and Anaphylaxis Research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- Celiac Disease Research and Management
- Diabetes and associated disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Transgenic Plants and Applications
Columbia University
2023-2025
Columbia University Irving Medical Center
2023-2024
Yale University
2019-2023
Cross-linking of high-affinity immunoglobulin E (IgE) results in the life-threatening allergic reaction anaphylaxis. Yet cellular mechanisms that induce B cells to produce IgE response allergens remain poorly understood. T follicular helper (TFH) direct affinity and isotype antibodies produced by cells. Although TFH cell-derived interleukin-4 (IL-4) is necessary for production, it not sufficient. We report a rare population IL-13-producing present mice humans with allergens, but when...
Loss of RNA homeostasis underlies numerous neurodegenerative and neuroinflammatory diseases. However, the molecular mechanisms that trigger neuroinflammation are poorly understood. Viral double-stranded (dsRNA) triggers innate immune responses when sensed by host pattern recognition receptors (PRRs) present in all cell types. Here, we report human neurons intrinsically carry exceptionally high levels immunostimulatory dsRNAs identify long 3'UTRs as giving rise to neuronal dsRNA structures....
Generation of peanut-specific gut immunoglobulin A antibodies is independent T follicular helper cells.
Summary Ku70 and Ku80 form Ku, a ring-shaped protein that initiates the non-homologous end-joining (NHEJ) DNA repair pathway. 1 Specifically, Ku binds to double-stranded (dsDNA) ends recruits other NHEJ factors ( e.g. , DNA-PKcs LIG4). While RNA (dsRNA) 2 traps mutated-DNA-PKcs on ribosomal in vivo, 3,4 physiological significance of Ku-dsRNA interactions otherwise wild-type cells remains elusive. Intriguingly, while dispensable for murine development, 5,6 is essential human cells. 7 Despite...