A5061215879- Rheumatoid Arthritis Research and Therapies
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Food Allergy and Anaphylaxis Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Drug-Induced Adverse Reactions
- Inflammatory Myopathies and Dermatomyositis
- Skin Diseases and Diabetes
- Myasthenia Gravis and Thymoma
- Platelet Disorders and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- Blood disorders and treatments
- Long-Term Effects of COVID-19
- Vascular Anomalies and Treatments
- Urticaria and Related Conditions
- Peripheral Neuropathies and Disorders
- Lymphoma Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Otitis Media and Relapsing Polychondritis
Tan Tock Seng Hospital
2019-2025
National University of Singapore
2022-2024
Nanyang Technological University
2022-2024
Center for Rheumatology
2021
National Centre for Infectious Diseases
2020
Abstract Sustained hypercoagulability and endotheliopathy are present in convalescent COVID‐19 patients for up to 4 months from recovery. The hemostatic, endothelial, inflammatory profiles of 39 recovered were evaluated 16 after recovery COVID‐19. These values compared with a control group healthy volunteers ( n = 124). (71.8% males, median age 43 years) reviewed at mean 12.7 ± 3.6 following One patient without cardiovascular risk factors had post acute ischaemic limb. Elevated D‐dimer...
Covid-19 vaccine associated cerebral venous thrombosis (CVT) are rare adverse events and can be considered as black swan events. "Black events", originally described by Nassim N. Taleb in economic theory, rare, unexpected whose potential to occur only becomes apparent after they have happened, where neither predicted nor anticipated, on retrospect, a clear basis is found for their occurrence that justifies randomness. The modified Adenovirus vector vaccines (ChAdOx1 nCoV-19...
Anaphylactic reactions were observed after Singapore’s national coronavirus disease 2019 (COVID-19) vaccination programme started in December 2020. We report the clinical and laboratory features of three patients our institution who developed anaphylactic receiving Pifzer BNT162b2 vaccine. IgM IgG antibodies, but not IgE antibodies to Pfizer vaccine, detected all subjects. Similarly, mild high elevated levels anti-polyethylene glycol (PEG) (1035–19709 U/mL, vs. vaccine-naive < 265...
The popular statistics-based Genome-wide association studies (GWAS) have provided deep insights into the field of complex disorder genetics. However, its clinical applicability to predict disease/trait outcomes remains unclear as statistical models are not designed make predictions. This study employs statistics-free machine-learning (ML)-optimized polygenic risk score (PRS) complement existing GWAS and bring prediction closer application. Rheumatoid Arthritis (RA) was selected a model...
Abstract Background The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, whether attenuates infection severity IEI. Objective To estimate examine effect on outcomes Methods We built a secure registry database conjunction the US Immunodeficiency Network to frequency indicators effectiveness IEI patients. opened January 1, 2022, closed August 19, 2022. Results Physicians entered data 1245 from 24...
Thymoma-associated immunodeficiency (TAI) is a rare, acquired adult-onset immunodeficiency. It includes the classic form of Good syndrome (GS), characterized by thymoma and hypogammaglobulinemia, as well non-classic GS. This condition leads to specific or combined deficiencies in both B- T-cells, causing considerable morbidity mortality, although underlying immunopathology still not understood. In this study, we examine clinical features, laboratory investigations, immunological analysis...
Hyperammonemia syndrome (HS) from Ureaplasma infection is typically reported in posttransplant recipients, particularly lung transplant. We describe a young woman with activated PI3K delta 2 who presented HS disseminated urealyticum septic arthritis. also performed literature review of Ureaplasma-associated nontransplant patients.
Abstract Aim This study was undertaken to determine the incidence and patterns of malignancies in rheumatoid arthritis (RA) patients our cohort. Methods Between 2001 2013, we analyzed 1117 prospective Tan Tock Seng Hospital (TTSH) RA Registry. Patients who developed after onset were identified from this registry. Age‐ sex‐adjusted standardized ratios (SIRs) calculated compare observed expected numbers based on data Singapore Cancer Results Out 19 839 person‐years follow‐up, 132 incident...
The underlying immunological mechanisms of immediate-type hypersensitivity reactions (HSR) to COVID-19 vaccines are poorly understood. We investigate the Pfizer BNT162b2 vaccine and response antibodies polyethylene glycol (PEG)ylated lipid nanoparticle after two doses vaccination. Sixty-seven participants, median age 35 77.3% females who tolerated (non-reactors), were subjected various blood-sampling time points. A separate group reactors (10 anaphylaxis 37 anonymised tryptase samples)...
Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody-associated dermatomyositis (DM) presenting with rapidly progressive interstitial lung disease (RP-ILD) is extremely challenging to treat. MDA5 a cytosolic viral RNA sensor that normally triggers an innate response resulting in interferon I production. Upregulation of expression can result autoantibody formation, leading overactivation the type pathway, causing aberrant metabolic remodeling peripheral B and T cells...
Abstract Objective To develop a hypothesis-free model that best predicts response to MTX drug in RA patients utilizing biologically meaningful genetic feature selection of potentially functional single nucleotide polymorphisms (pfSNPs) through robust machine learning (ML) methods. Methods MTX-treated with known were divided 4:1 ratio into training and test sets. From the patients’ exomes, potential features for classifier prediction identified from pfSNPs non-genetic factors ML using...
The Montreal Cognitive Assessment (MoCA) is an increasingly used screening tool for cognitive impairment. aim of this study was to examine how MoCA performed in identifying impairment (CI) domains SLE patients compared with formal standardized neuropsychological testing (NPT). Factors related disease, immunologic and psychological state associated CI were also explored.This cross-sectional recruited 50 without overt neuropsychiatric manifestations from April 2017 May 2018. evaluated MoCA,...
During the initial rollout of coronavirus disease 2019 (COVID-19) vaccination in Singapore, Ministry Health (MOH) issued a recommendation that patients with history any previous vaccine allergy be referred to an allergist for further review their suitability proceed mRNA-based COVID-19 vaccines. Patients fulfilling above criterion were divided into three groups: immediate reaction (Group A), delayed B) and no/irrelevant C). They subjected either skin prick test (SPT) intradermal (IDT)...
There is a paucity of information on the cytokine, complement, endothelial activation, and coagulation profiles multisystem inflammatory syndrome in adults (MIS-A), rare but serious complication following recovery from SARS-CoV-2 infection. We aim to examine immune biomarker association with clinical presentation course MIS-A.The features MIS-A patients admitted our tertiary hospital were documented. Their levels interleukin (IL)-1β, IL-6, IL-10, IL-17, IL-18, interferon-α (IFN-α), IFN-γ,...