A5060370412- Long-Term Effects of COVID-19
- Peripheral Neuropathies and Disorders
- COVID-19 Clinical Research Studies
- Pain Mechanisms and Treatments
- SARS-CoV-2 and COVID-19 Research
- Botulinum Toxin and Related Neurological Disorders
- Cerebral Venous Sinus Thrombosis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Retinal and Optic Conditions
- COVID-19 and Mental Health
- Peripheral Nerve Disorders
- Hereditary Neurological Disorders
- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- Alzheimer's disease research and treatments
- Acupuncture Treatment Research Studies
- Psychological Well-being and Life Satisfaction
- Multiple Sclerosis Research Studies
- Cerebrospinal fluid and hydrocephalus
- Genetic Neurodegenerative Diseases
- Graph theory and applications
- Malaria Research and Control
- Intracerebral and Subarachnoid Hemorrhage Research
- Cervical and Thoracic Myelopathy
- Bacterial Infections and Vaccines
Tan Tock Seng Hospital
2020-2025
National Neuroscience Institute
2020-2025
Neurology, Inc
2022
National University of Singapore
2011
National Institute of Allergy and Infectious Diseases
2000
National Institutes of Health
2000
Acute ischemic stroke (AIS) is a known neurological complication in patients with respiratory symptoms of COVID-19 infection. However, AIS has not been described as late sequelae without COVID-19.To assess experienced by adults 50 years or younger the convalescent phase asymptomatic infection.This case series prospectively identified consecutive male who received care for from public health hospitals Singapore between May 21, 2020, and October 14, 2020. All these had laboratory-confirmed...
To describe the spectrum of COVID-19 neurology in Singapore.
Covid-19 vaccine associated cerebral venous thrombosis (CVT) are rare adverse events and can be considered as black swan events. "Black events", originally described by Nassim N. Taleb in economic theory, rare, unexpected whose potential to occur only becomes apparent after they have happened, where neither predicted nor anticipated, on retrospect, a clear basis is found for their occurrence that justifies randomness. The modified Adenovirus vector vaccines (ChAdOx1 nCoV-19...
<h3>Importance</h3> Reports of cerebral venous thrombosis (CVT) after messenger RNA (mRNA)-based SARS-CoV-2 vaccination has caused safety concerns, but CVT is also known to occur infection. Comparing the relative incidence infection vs may provide a better perspective this complication. <h3>Objective</h3> To compare rates and clinical characteristics following either or mRNA-based vaccines. <h3>Design, Setting, Participants</h3> Between January 23, 2020, August 3, 2021, observational cohort...
Studies of hereditary transthyretin amyloidosis (ATTRv amyloidosis) in South-East Asia are underrepresented the literature. We report unique phenotypic and genetic characteristics this disorder a multiracial Asian cohort.Patients with genetically proven ATTRv were identified over 13-year period (2007-2020) at National Neuroscience Institute, Singapore. Clinical, laboratory, genotypic electrophysiological features retrospectively reviewed.29 patients comprising Chinese, Malay, Burmese,...
Abstract Background To investigate the relationship between obesity and corneal nerve metrics in patients with type 2 diabetes mellitus (DM). Methods This cross-sectional study included a total of 385 healthy controls 663 DM. Metrics for epithelial cells were evaluated using in-vivo confocal microscopy (IVCM). Corneal cell parameters quantified compared without across six different body mass index (BMI) categories. Multivariable regression analyses conducted to determine association BMI...
Anti-Pv200 antibody levels were assessed in samples from endemic areas of Plasmodium vivax malaria the Republic Korea (ROK), using an indirect enzyme-linked immunosorbent assay (ELISA) method. Asymptomatic carriers P. detected nested polymerase chain reaction (PCR) blood samples. 20 patients (optical density +/- standard deviation [OD SD] values 1.85 0.29 IgG isotype and 1.33 IgM isotype) markedly higher than those uninfected, malaria-naive controls (0.08 0.16 0.04 isotype). Antibody for 7...
Summary Background Individuals who suffered a neurological adverse event after the Coronavirus disease (COVID-19) vaccine could hesitate and defer reimmunization. Aim We examine risk of recurrence following reimmunization among patients developed first dose COVID-19 mRNA vaccine. Design Observational study. Methods an adjudicated (based on Brighton Collaboration criteria) within 6 weeks requiring hospitalization were enrolled into multicenter national registry in Singapore. Neurological...
Literature describing triggers of GFAP astrocytopathy (GFAP-A) is limited. We report a case GFAP-A in patient with recent messenger ribonucleic acid (mRNA) severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) vaccination and discuss the possible pathogenesis. A 45-year-old gentleman presented features meningoencephalitis 31 days after first dose 4 second mRNA SARS-CoV-2 vaccination. He sequentially developed brainstem/cerebellar, autonomic cord dysfunction. Cerebrospinal fluid was...
We present an exemplar patient, illustrating utility of the sural-sparing pattern in diagnosis Guillain-Barré Syndrome (GBS). then data that sheds light on pathophysiology sural-sparing.We describe a case complex ophthalmoplegia exemplifies challenge diagnosing regional subtypes Syndrome, and value scrutinizing sensory nerve action potentials for pattern. also demonstrate, series GBS patients, how serial conduction studies can reveal "covert" patients without initial study. Finally, by...
We describe a cohort of five patients with limb-girdle muscular dystrophy (LGMD) 2G/LGMD-R7 in South-east Asian cohort.LGMD2G/LGMD-R7-telethonin-related is caused by mutations the TCAP gene that encodes for telethonin.We identified consecutive LGMD2G/LGMD-R7-telethonin-related, diagnosed at National Neuroscience Institute (NNI) and University Hospital (NUH) between January 2000 June 2021.At onset, three presented proximal lower limb weakness, one patient Achilles tendon contractures, delayed...
Abstract Background We report a patient with novel c.737 C > T variant (p.Ser246Leu) of the TPM3 gene presenting adult-onset distal myopathy. Case presentation A 35-year-old Chinese male presented history progressive finger weakness. Physical examination revealed differential extension weakness, together predominant abduction, elbow flexion, ankle dorsiflexion and toe Muscle MRI showed disproportionate fatty infiltration glutei, sartorius extensor digitorum longus muscles without...
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Chronic immune sensory polyradiculopathy (CISP) is an uncommon and treatable inflammatory disorder of the proximal nerve roots. Patients typically present with severe ataxia, normal motor examination, unsteady gait, conduction studies (NCS). We describe elderly man who presented a two-week history progressive numbness both legs recurrent falls. He had hyporeflexia, strength, proprioceptive, vibration sense loss in lower limbs was unable to stand or walk because ataxia. The NCS MR scan spine...
Charcot-Marie-Tooth type 1A (CMT1A) is typically characterised as a childhood-onset, symmetrical, length-dependent polyneuropathy with gradual progressive clinical course. Acute to subacute neurological deterioration in CMT1A rare, and has been reported secondary overlap pathologies including inflammatory neuropathy. We identified two patients who presented acute subacute, atraumatic, entrapment neuropathies an initial symptom. A superimposed neuropathy was excluded. Both had diffuse...