A5071122855- Acute Ischemic Stroke Management
- Mosquito-borne diseases and control
- Peripheral Neuropathies and Disorders
- Cerebrovascular and Carotid Artery Diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Antioxidant Activity and Oxidative Stress
- S100 Proteins and Annexins
- Neurological disorders and treatments
- Malaria Research and Control
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- Antiplatelet Therapy and Cardiovascular Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neurological Disorders and Treatments
- Neuroscience of respiration and sleep
- Genetic Neurodegenerative Diseases
- Eicosanoids and Hypertension Pharmacology
- Hereditary Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Cerebral Venous Sinus Thrombosis
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Botulinum Toxin and Related Neurological Disorders
- Palliative Care and End-of-Life Issues
National University of Singapore
2011-2025
National University Hospital
2010-2025
National University Health System
2012-2024
University Health System
2020
BackgroundWe examined whether existing licensed pharmacotherapies could reduce the spread of coronavirus disease 2019 (COVID-19).MethodsAn open-label parallel randomized controlled trial was performed among healthy migrant workers quarantined in a large multi-storey dormitory Singapore. Forty clusters (each defined as individual floors dormitory) were randomly assigned to receive 42-day prophylaxis regimen either oral hydroxychloroquine (400 mg once, followed by 200 mg/day), ivermectin (12...
This case series reports three patients initially managed for presumed infectious meningoencephalitis, who were ultimately diagnosed with myelin oligodendrocyte glycoprotein associated disease (MOGAD). Their clinical presentations strikingly similar to those of acute which posed a challenge the initial diagnostic process. Notably, despite absence typical radiological changes MOGAD, such as cerebral cortical encephalitis, these exhibited focal neurological and electroencephalographic changes....
<h3>Importance</h3> Reports of cerebral venous thrombosis (CVT) after messenger RNA (mRNA)-based SARS-CoV-2 vaccination has caused safety concerns, but CVT is also known to occur infection. Comparing the relative incidence infection vs may provide a better perspective this complication. <h3>Objective</h3> To compare rates and clinical characteristics following either or mRNA-based vaccines. <h3>Design, Setting, Participants</h3> Between January 23, 2020, August 3, 2021, observational cohort...
Considerable data implicate oxidative damage in influenza pathogenesis. We examined temporal changes using accurate biomarkers an adult cohort with acute infection and their relationships clinical parameters. Clinical information blood samples were collected during illness 3 months later. A fatigue questionnaire was administered following infection. Thirty-five patients (mean age, 34 years) polymerase chain reaction-confirmed included; all returned for follow-up assessments. Adjusted levels...
We describe the case history of three patients with meningoencephalitis who were initially treated for presumed tuberculous before being diagnosed autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. highlight overlapping clinical features between GFAP astrocytopathy and challenges in early diagnosis, as both entities respond to an initial course steroids accompanying antituberculous medications. Early evaluation GFAP-immunoglobulin G cerebrospinal fluid present aseptic could...
Evidence on the efficacy of high-dose coenzyme Q10 (CoQ10) in Parkinson's disease (PD) is conflicting. An open-label dose-escalation study was performed to examine effects CoQ10 biomarkers oxidative damage and clinical outcomes 16 subjects with early idiopathic PD. Each dose (400, 800, 1200, 2400 mg/day) consumed daily for 2 weeks. High-dose well tolerated improvements total Unified Disease Rating Scale (median, 37 vs. 27; p=0.048) were observed following completion. Plasma F2-isoprostanes...
Abstract Introduction: This study aimed to investigate the knowledge, attitudes and perceptions (KAP) of advance care planning (ACP) among specialist healthcare professionals (HCPs) in neurology, neuro-oncology surgery. Methods: was a cross-sectional HCPs Singapore. A standardised questionnaire developed using validated questionnaires from international literature, concepts Theory Planned Behaviour consultation with multidisciplinary palliative specialists. The 45-item included sections on...
We performed a case-control study to assess the relationship between vascular endothelial growth factor (VEGF) and its soluble receptors (sVEGFR-1 2) in adult patients with dengue fever (DF) hemorrhagic (DHF).We recruited 60 (34 DF 26 DHF) serologically-confirmed infections, 10 non-hemorrhagic 31 community-based healthy volunteers. The levels of VEGF, sVEGFR-1, sVEGFR-2 were measured differences these markers compared using one-way analysis variance (ANOVA), which was adjusted for multiple...
OBJECTIVE The role of oxidative damage in the pathogenesis metabolic syndrome is poorly understood. RESEARCH DESIGN AND METHODS A detailed cross-sectional study was performed to assess relationship between lipid oxidation products, γ-glutamyltransferase, high-sensitivity C-reactive protein (hs-CRP), and phospholipase activities with respect status a cohort otherwise healthy individuals. RESULTS total 179 individuals (87 men 92 women) aged 43 ± 14 years (mean SD) participated this study....