A5079039508- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Infectious Encephalopathies and Encephalitis
- Neuroscience and Neuropharmacology Research
- Bacterial Infections and Vaccines
- Infant Development and Preterm Care
- Genomics and Rare Diseases
- Neural dynamics and brain function
- SARS-CoV-2 and COVID-19 Research
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Functional Brain Connectivity Studies
- Blood Coagulation and Thrombosis Mechanisms
- Mitochondrial Function and Pathology
- Peripheral Neuropathies and Disorders
- Neurological and metabolic disorders
- Acute Ischemic Stroke Management
- Pharmaceutical studies and practices
- Autoimmune Neurological Disorders and Treatments
- Neurological disorders and treatments
- Neuroscience of respiration and sleep
- Cardiac Structural Anomalies and Repair
- Neonatal Respiratory Health Research
KK Women's and Children's Hospital
2013-2024
Duke-NUS Medical School
2020-2024
Media Working Group
2024
Singapore General Hospital
2021-2024
SingHealth Duke-NUS Academic Medical Centre
2020-2023
University Health Network
2018
Toronto General Hospital
2018
Boston Children's Hospital
2010-2015
University of Toronto
2008-2013
Hospital for Sick Children
2008-2013
Abstract Epileptogenic triggers are multifactorial and not well understood. Here we aimed to address the hypothesis that inappropriate pro-inflammatory mechanisms contribute pathogenesis of refractory epilepsy (non-responsiveness antiepileptic drugs) in human patients. We used single-cell cellular indexing transcriptomes epitopes by sequencing (CITE-seq) reveal immunotranscriptome surgically resected epileptic lesion tissues. Our approach uncovered a microenvironment, including extensive...
This work aims to develop an end-to-end solution for seizure onset detection. We design the SeizNet, a Convolutional Neural Network To compare SeizNet with traditional machine learning approach, baseline classifier is implemented using spectrum band power features Support Vector Machines (BPsvm). explore possibility use least number of channels accurate detection by evaluating and BPsvm approaches all two settings respectively. EEG Data acquired from 29 pediatric patients admitted KK Woman's...
This paper proposes a color-based video analytic system for quantifying limb movements in epileptic seizure monitoring. The utilizes colored pyjamas to facilitate segmentation and tracking. Thus, it is unobtrusive requires no sensor/marker attached patient's body. We employ Gaussian mixture models background/foreground modeling detect limbs through coarse-to-fine paradigm with graph-cut-based segmentation. Next, we estimate parameters domain knowledge guidance extract displacement...
To determine the association between severe cutaneous drug reactions (SCDR), HLA-B*1502 allelism, carbamazepine dose and treatment duration in a Singapore paediatric population.Case-control study of SCDR with HLA-B*1502. We recruited 32 cases, 5 Steven Johnson Syndrome/Toxic Epidermolytic Necrolysis (SJS/TEN) (2 Chinese, 3 Malay), 6 hypersensitivity syndrome (HSS) (5 1 Indian), 11 minor (9 2 Malay) 10 controls (7 Malay, Indian). allelism was assayed. status type reaction were compared using...
Drug refractory epilepsy (RE) is a chronic neurological disease with varied etiology that represents group of patients whose seizures do not respond to anti-epileptic drugs. The immune system may have role in seizure and development, but the specific mechanisms inflammation lead epileptogenesis contribute RE are unknown. Here, we used mass cytometry comprehensively study pediatric compared their profile function age-matched autoimmune encephalitis (AIE) healthy controls. Patients AIE...
At present, there is no internationally accepted set of core outcomes or measurement methods for epilepsy clinical practice. The International Consortium Health Outcomes Measurement (ICHOM) convened an international working group experts in epilepsy, people with and their representatives to develop minimum sets standardized outcome Using modified Delphi consensus consecutive rounds online voting over 12 months, a corresponding tool packages capture the were identified infants, children,...
Purpose: We developed a technique to produce images of dynamic changes in ictal high-frequency oscillations (HFOs) >40 Hz recorded on subdural electroencephalography (EEG) that are time-locked the EEG and semiology video. applied this Jacksonian seizures demonstrate HFO propagation along homunculus primary sensory-motor cortex visualize underlying epileptic network. Methods: analyzed intracranial EEGs from two patients with intractable who underwent epilepsy surgery. calculated degrees...
Background: Although inappropriate shocks are known to be an important consequence of implantable cardioverter‐defibrillators (ICDs), the subjective experience pain intensity perceived by those receiving versus appropriate has not previously been examined. Methods: One hundred ICD patients underwent a standardized interview investigator blinded clinical history. Patients with previous shock were asked describe associated on standard 0–10 scale (10 being worst they had ever experienced)....
Approximately 30% of patients with hypertension have hepatic steatosis, and it has recently been proposed that fatty liver be considered a feature the metabolic syndrome. Obesity, diet, level physical activity are likely factors modulating risk for however genetic could also influence susceptibility or resistance to in hypertensive normotensive subjects. In studies spontaneously rats (SHRs) Brown Norway (BN) rats, we discovered variant form sterol regulatory element binding transcription...
Febrile illness-related epilepsy syndrome is a catastrophic epileptic encephalopathy that highly refractory to most antiepileptic drugs leading high morbidity and mortality. The authors report the use of pediatric infusion protocol continuous intravenous magnesium sulfate for control seizures in 2 children with febrile multiple intensive care unit tertiary children’s hospital. Both patients, 16 years age, respectively, were treated infusion. Serum concentrations ranging from 2.1 5 mmol/L...
In this work we propose a non-intrusive video analytic system for patient's body parts movement analysis in Epilepsy Monitoring Unit. The utilizes skin color modeling, head/face pose template matching and face detection to analyze quantify the head movements. Epileptic patients' heads are analyzed holistically infer seizure normal random patient does not require wear any special clothing, markers or sensors, hence it is totally non-intrusive. user initializes person-specific selects few...
Hemophagocytic lymphohistiocytosis is a rare childhood disorder characterized by uncontrolled proliferation of benign lymphocytes and histiocytes in multiple organs. Neurological presentations central nervous system involvement are highly variable. The authors present case familial hemophagocytic an 8-month-old girl with isolated reactivation optic nerve involvement. She presented fever hepatosplenomegaly at 2 months age. Genetic studies confirmed lymphohistiocytosis. There were no clinical...