A5026618924- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Fetal and Pediatric Neurological Disorders
- Ion channel regulation and function
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Forensic Toxicology and Drug Analysis
- Neurotransmitter Receptor Influence on Behavior
- Atomic and Subatomic Physics Research
- Tuberous Sclerosis Complex Research
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Cardiac electrophysiology and arrhythmias
- Adipose Tissue and Metabolism
- Glioma Diagnosis and Treatment
University of Toronto
2014-2023
Hospital for Sick Children
2014-2023
SickKids Foundation
2010-2023
Public Health Ontario
2022
University Health Network
2022
Canada Research Chairs
2013-2021
Kensington Health
2019
Pediatrics and Genetics
2006-2019
Neurology, Inc
2005-2018
Mental Health Research Canada
2013-2016
Abstract The International League Against Epilepsy (ILAE) Task Force on Nosology and Definitions proposes a classification definition of epilepsy syndromes in the neonate infant with seizure onset up to 2 years age. incidence is high this age group frequently associated significant comorbidities mortality. licensing syndrome specific antiseizure medications following randomized controlled trials development precision, gene‐related therapies are two drivers defining electroclinical phenotypes...
PurposeGenetic testing is an integral diagnostic component of pediatric medicine. Standard care often a time-consuming stepwise approach involving chromosomal microarray analysis and targeted gene sequencing panels, which can be costly inconclusive. Whole-genome (WGS) provides comprehensive platform that has the potential to streamline genetic assessments, but there are limited comparative data guide its clinical use.MethodsWe prospectively recruited 103 patients from non-genetic...
To update the 2004 American Academy of Neurology/Child Neurology Society practice parameter on treatment infantile spasms in children.MEDLINE and EMBASE were searched from 2002 to 2011 searches reference lists retrieved articles performed. Sixty-eight selected for detailed review; 26 included analysis. RECOMMENDATIONS based a 4-tiered classification scheme combining pre-2002 evidence more recent evidence.There is insufficient determine whether other forms corticosteroids are as effective...
Purpose: High-frequency oscillations (HFOs), termed ripples at 80–200 Hz and fast (FRs) >200/250 Hz, recorded by intracranial electroencephalography (EEG), may be a valuable surrogate marker for the localization of epileptogenic zone. We evaluated relationship resection focal brain regions containing high-rate interictal HFOs seizure-onset zone (SOZ) determined visual EEG analysis with postsurgical seizure outcome, using extraoperative monitoring in pediatric patients automated HFO...
Epilepsy is a common neurologic disorder of childhood. To determine the genetic diagnostic yield in epileptic encephalopathy, we performed retrospective cohort study single epilepsy genetics clinic.We included all patients with intractable epilepsy, global developmental delay, and cognitive dysfunction seen between January 2012 June 2014 Genetics Clinic. Electronic patient charts were reviewed for clinical features, neuroimaging, biochemical investigations, molecular investigations including...
Epilepsy syndromes have been recognized for >50 years, as distinct electroclinical phenotypes with therapeutic and prognostic implications. Nonetheless, no formally accepted International League Against (ILAE) classification of epilepsy has existed. The ILAE Task Force on Nosology Definitions was established to reach consensus regarding which entities fulfilled criteria an syndrome provide definitions each syndrome. We defined "a characteristic cluster clinical electroencephalographic...
Objective. To compare the efficacy of corticotropin (ACTH) (150 U/m2/day) and prednisone (2 mg/kg/day), given for 2 weeks, in suppressing clinical spasms hypsarrhythmic electroencephalogram (EEG) infantile (IS). ACTH are standard treatments IS. at high doses causes severe dose- duration-dependent side effects, but may be superior to prednisone, based on retrospective or uncontrolled studies. Blinded prospective studies have shown equal low-dose ACTH, low versus high-dose ACTH. Design. A...
Summary: Purpose: To characterize the spatial and temporal course of ictal high‐frequency oscillations (HFOs) recorded by subdural EEG in children with intractable neocortical epilepsy. Methods: We retrospectively studied nine (four girls, five boys; 4–17 yr) who presented extrahippocampal localization‐related epilepsy underwent extraoperative video (1000 Hz sampling rate) cortical resection. performed multiple band frequency analysis (MBFA) to evaluate frequency, time course, distribution...
Synchronization is a fundamental characteristic of complex systems and basic mechanism self-organization. A traditional, accepted perspective on epileptiform activity holds that hypersynchrony covering large brain regions hallmark generalized seizures. However, few recent reports have described substantial fluctuations in synchrony before during ictal events, thus raising questions as to the widespread synchronization notion. In this study, we used magnetoencephalographic recordings from...
Dysembryoplastic neuroepithelial tumors (DNTs) are associated with medically intractable epilepsy and a favorable prognosis after surgical resection. The authors describe the clinical, radiologic, pathologic characteristics outcomes in children resection of pathologically confirmed DNT to ascertain prognostic features for seizure recurrence following surgery.Neurology, neurosurgery, pathology databases from 1993 2002 at Hospital Sick Children were searched retrospectively identify...
Bipolar disorder is a debilitating psychopathology with unknown etiology. Accumulating evidence suggests the possible involvement of Na + ,K -ATPase dysfunction in pathophysiology bipolar disorder. Here we show that Myshkin mice carrying an inactivating mutation neuron-specific α3 subunit display behavioral profile remarkably similar to patients manic state. increased Ca 2+ signaling cultured cortical neurons and phospho-activation extracellular signal regulated kinase (ERK) Akt hippocampus....
Gamma-Hydroxybutyric acid (GHB), a compound that has interesting neuropharmacological actions when administered systemically, was shown by means of gas chromatography-mass spectrometry to be present in postmortem samples human brain concentrations ranging from 2 20 nmol/g. Tissue the basal ganglia contained 3 times as much GHB tissue cortical regions. The regional distribution examined guinea pig and rhesus monkey found parallel observed brain. levels areas investigated were higher than...
Both Δ9 Tetrahydrocannabidiol (THC) and cannabidiol (CBD) components of cannabis, have been shown to anticonvulsant effects. Cannabis oils are used treat seizures in drug-resistant epilepsy (DRE). Recent trials provide data on dosing, side effects, efficacy CBD, yet there is a paucity information THC epilepsy. Primary objective was establish dosing tolerability TIL-TC150 - cannabis plant extract produced by Tilray®, containing 100 mg/mL CBD 2 THC- children with Dravet syndrome. Secondary...
The transition from a pediatric to adult health care system is challenging for many youths with epilepsy and their families. Recently, the Ministry of Health Long-Term Care Province Ontario, Canada, created working group (TWG) develop recommendations process patients in Ontario. Herein we present an executive summary this work. TWG was composed multidisciplinary epileptologists, psychiatrists, family doctors academia community; neurologists nurses social workers programs; adolescent medicine...
Objective Vagus nerve stimulation (VNS) is a common treatment for medically intractable epilepsy, but response rates are highly variable, with no preoperative means of identifying good candidates. This study aimed to predict VNS using structural and functional connectomic profiling. Methods Fifty‐six children, comprising discovery (n = 38) validation 18) cohorts, were recruited from 3 separate institutions. Diffusion tensor imaging was used identify group differences in white matter...
The object of this study was to determine the concordance anatomical location interictal magnetoencephalographic (MEG) spike foci with ictal onset zones identified by invasive intracranial electroencephalographic recordings in children undergoing evaluation for epilepsy surgery. MEG performed 11 intractable, nonlesional, extratemporal, localization-related epilepsy. Subsequently, chronic monitoring using subdural electrodes localize zone and eloquent cortex. Based on data, all had excision...
Summary: Purpose: To discover whether the spatial distribution of spike sources determined by magnetoencephalography (MEG) provides reliable information for planning surgery and predicting outcomes in pediatric patients with lesional extrahippocampal epilepsy. Methods: We retrospectively studied 12 children epilepsy secondary to cortical dysplasia (CD), tumor, or porencephalic cyst. compared interictal MEG source locations somatosensory evoked fields derived from equivalent‐current dipole...