A5077821702- Epilepsy research and treatment
- Cerebrospinal fluid and hydrocephalus
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Pharmacological Effects and Toxicity Studies
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Spinal Dysraphism and Malformations
- Neonatal Respiratory Health Research
- Vascular Malformations Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Cord Injury Research
- Ocular Oncology and Treatments
- Vagus Nerve Stimulation Research
- Adversarial Robustness in Machine Learning
- Tuberous Sclerosis Complex Research
- EEG and Brain-Computer Interfaces
- Intracranial Aneurysms: Treatment and Complications
- Head and Neck Surgical Oncology
- Nerve injury and regeneration
- Cardiac Arrest and Resuscitation
- Global Health and Surgery
- Neurofibromatosis and Schwannoma Cases
- Neurogenesis and neuroplasticity mechanisms
Miami Children's Hospital
2019-2025
University of Miami
2019-2024
Neurological Surgery
2021-2024
Walter and Eliza Hall Institute of Medical Research
2024
Jackson Memorial Hospital
2022-2024
Allen Institute for Brain Science
2022
University of Waterloo
2022
Carleton University
2020
University of Toronto
2013-2019
Medical University of South Carolina
2019
Cellular transplantation strategies for repairing the injured spinal cord have shown consistent benefit in preclinical models, and human clinical trials begun. Interactions between transplanted cells host tissue remain poorly understood. Trophic factor secretion is postulated a primary or supplementary mechanism of action many cells, however, there little direct evidence to support trophin production by situ. In present study, trophic expression was characterized uninjured,...
Objective Vagus nerve stimulation (VNS) is a common treatment for medically intractable epilepsy, but response rates are highly variable, with no preoperative means of identifying good candidates. This study aimed to predict VNS using structural and functional connectomic profiling. Methods Fifty‐six children, comprising discovery (n = 38) validation 18) cohorts, were recruited from 3 separate institutions. Diffusion tensor imaging was used identify group differences in white matter...
Abstract BACKGROUND Despite the well-documented utility of responsive neurostimulation (RNS, NeuroPace) in adult epilepsy patients, literature on use RNS children is limited. OBJECTIVE To determine real-world efficacy and safety pediatric patients. METHODS Patients with childhood-onset drug-resistant treated were retrospectively identified at 5 centers. Reduction disabling seizures complications evaluated for (<18 yr) young adults (>18 compared prior pertaining to RESULTS Of 35...
The mechanisms by which neural precursor cells (NPCs) enhance functional recovery from spinal cord injury (SCI) remain unclear. Spinal injured rats were transplanted with wild-type mouse NPCs, shiverer NPCs unable to produce myelin, dead or media. Most animals also received minocycline, cyclosporine, and perilesional infusion of trophins. Motor function was graded according the BBB scale. H&E/LFB staining used assess gray white matter, cyst, lesional tissue. Mature oligodendrocytes ED1 +...
Desmoplastic infantile ganglioglioma (DIG) and desmoplastic astrocytoma (DIA) are extremely rare tumors that typically arise in infancy; however, these entities have not been well characterized terms of genetic alterations or clinical outcomes. Here, through a multi-institutional collaboration, the largest cohort DIG/DIA to date is examined using advanced laboratory data processing techniques. Targeted DNA exome sequencing methylation profiling were performed on tumor specimens obtained from...
Magnetic resonance-guided focused ultrasound (MRgFUS) is an incisionless procedure capable of thermoablation through the focus multiple acoustic beams. Although MRgFUS currently approved for treatment tremor in adults, its safety and feasibility profile intracranial lesions pediatric young adult population remains unknown.
OBJECTIVE A recent survey has shown that caregivers of children with shunt-treated hydrocephalus frequently use social media networks for support and information gathering. The objective this study is to describe assess utilization among users interested in hydrocephalus. METHODS Publicly accessible accounts videos dedicated the topic were comprehensively searched across 3 platforms (Facebook, Twitter, YouTube) throughout March 2016. Summary statistics calculated on standard metrics...
There is substantial variability in reported seizure outcome following pediatric epilepsy surgery, and lack of individualized predictive tools that could evaluate the probability freedom postsurgery. The aim this study was to develop validate a supervised machine learning (ML) model for predicting after surgery.This multicenter retrospective children who underwent surgery at five centers North America. Clinical information, diagnostic investigations, surgical characteristics were collected,...
OBJECTIVE Endoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid neuroendoscopy can be used, with little empirical evidence directly comparing two. Therefore, authors used a propensity score-matched cohort survival analysis to assess comparative efficacy neuroendoscopy. METHODS Individual data were collected through retrospective review infants younger than 2...
Minimally invasive magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) has been proposed as an alternative to open epilepsy surgery, address concerns regarding the risk of surgery. Our primary hypothesis was that seizure freedom at 1 year after MRgLITT is noninferior surgery in children with drug-resistant (DRE). The secondary fewer complications and shorter hospitalization than objective compare outcome DRE. length two treatments.This retrospective multicenter cohort...
OBJECTIVE Although hemispherectomy is an effective treatment for children with intractable hemispheric epilepsy syndromes, as many 40% of patients eventually develop seizure recurrence. The causes recurrence in these are incompletely understood. authors sought to evaluate the efficacy at their center and determine whether contralateral MRI abnormalities can predict METHODS A retrospective review consecutive hemispherectomies performed Miami Children’s Hospital between January 2000 June 2014...
ABSTRACT Aims : ESES is a developmental epileptic disorder directly responsible for progressive encephalopathy and neurocognitive regression. The natural history, indications surgical intervention, predictors favorable seizure neuropsychological outcome remain unclear. Methods We performed retrospective review of children who underwent resective or disconnective surgery between January 2009 July 2016 at large tertiary pediatric center. Information on the patients’ demographics, semiology,...
Chiari malformation type I (CMI) is relatively common neurosurgical condition typically treated with posterior fossa decompression. However, the management of CMI in patients heritable connective tissue disorders (CTDs), such as Ehlers-Danlos Syndrome, Marfan or Osteogenesis Imperfecta, involves a unique set perioperative challenges.This study aims to define demographic information, comorbidities, and course concomitant CTD.Patients admitted for surgical decompression from 2008 2015 were...
OBJECTIVE Uncontrolled epilepsy is associated with serious deleterious effects on the neurological development of infants and has been described as “catastrophic epilepsy.” Recently, there increased emphasis early surgical interventions to preserve or rescue neurodevelopmental outcomes in intractable epilepsy. The enthusiasm for treatments often tempered by concerns regarding morbidity neurosurgical procedures very young patients. Here, authors report following management (younger than 1...