A5070608864- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Botulinum Toxin and Related Neurological Disorders
- Infant Development and Preterm Care
- Cerebral Palsy and Movement Disorders
- Neonatal Respiratory Health Research
- Photoreceptor and optogenetics research
- Vagus Nerve Stimulation Research
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Organ Transplantation Techniques and Outcomes
- Healthcare Policy and Management
- Pharmacological Effects and Toxicity Studies
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury Research
University of Toronto
2014-2023
Hospital for Sick Children
2013-2020
Mental Health Research Canada
2019
SickKids Foundation
2014-2016
Western Sydney University
2016
Cardiff University
2015
St. Michael's Hospital
2014
Jersey Shore University Medical Center
2014
University of Minnesota
2011-2014
Twin Cities Orthopedics
2013
The effects of interictal epileptiform discharges on neurocognitive development in children with medically-intractable epilepsy are poorly understood. Such may have a deleterious effect the brain's intrinsic connectivity networks, which reflect organization functional networks at rest, and turn development. Using combined magnetic resonance imaging-magnetoencephalography approach, we examine outcome. Functional imaging was used to determine location regions comprising various 26 (7-17...
Objective Vagus nerve stimulation (VNS) is a common treatment for medically intractable epilepsy, but response rates are highly variable, with no preoperative means of identifying good candidates. This study aimed to predict VNS using structural and functional connectomic profiling. Methods Fifty‐six children, comprising discovery (n = 38) validation 18) cohorts, were recruited from 3 separate institutions. Diffusion tensor imaging was used identify group differences in white matter...
Magnetoencephalographic (MEG) investigations of inter-regional amplitude correlations have yielded new insights into the organization and neurophysiology resting-state networks (RSNs) first identified using fMRI. Inter-regional MEG in adult RSNs been shown to be most prominent alpha beta frequency ranges express strong congruence with RSN topologies found Despite such advances, little is known about how oscillatory connectivity develops throughout childhood adolescence. This study used a...
Although chronic vagus nerve stimulation (VNS) is an established treatment for medically-intractable childhood epilepsy, there considerable heterogeneity in seizure response and little data are available to pre-operatively identify patients who may benefit from treatment. Since the therapeutic effect of VNS be mediated by afferent projections thalamus, we tested hypothesis that intrinsic thalamocortical connectivity associated with following children epilepsy. Twenty-one (ages 5-21 years)...
Abstract Typical childhood development is characterized by the emergence of intrinsic connectivity networks (ICNs) way internetwork segregation and intranetwork integration. The impact epilepsy on maturation ICNs is, however, poorly understood. developmental trajectory in 26 children (8–17 years) with localization‐related 28 propensity‐score matched controls was evaluated using graph theoretical analysis whole brain connectomes from resting‐state functional magnetic resonance imaging (fMRI)...
Working memory (WM) - temporary storage and manipulation of information in the mind is a key component cognitive maturation, structural brain changes throughout development are associated with refinements WM. Recent functional neuroimaging studies have shown that there greater activation prefrontal parietal regions increasing age, adults showing more refined, localized patterns activations. However, few investigated neural basis verbal WM development, as majority reports examine...
Research on the neural bases of cognitive deficits in autism spectrum disorder (ASD) has shown that working memory (WM) difficulties are associated with abnormalities prefrontal cortex. However, load impacts these findings, and no studies have examined relation between WM underpinnings children ASD. Thus, current study determined effects WM, using a visuo-spatial capacity task without ASD functional magnetic resonance imaging (fMRI).We used fMRI 1-back colour matching (CMT) four levels...
The underlying microstructural properties of white matter differences in children born very preterm (<32 weeks gestational age) can be investigated depth using multi-shell diffusion imaging. present study compared across the whole brain tensor imaging (DTI) and neurite orientation dispersion density (NODDI) metrics full-term at six years age. We also associations between microstructure with early injury developmental outcomes. Multi-shell imaging, T1-weighted anatomical MR images assessments...
Identifying trajectories of early white matter development is important for understanding atypical brain and impaired functional outcomes in children born very preterm (<32 weeks gestational age [GA]). In this study, 161 diffusion images were acquired (median GA: 29 weeks) shortly following birth (75), term-equivalent (39), 2 years (18), 4 (29). Diffusion tensors computed to obtain measures fractional anisotropy (FA), mean diffusivity (MD), axial (AD), radial (RD), which aligned averaged. A...
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental characterised by diminished social reciprocity and communication skills the presence of stereotyped restricted behaviours. Executive functioning deficits, such as working memory, are associated with core ASD symptoms. Working memory allows for temporary storage manipulation information relies heavily on frontal-parietal networks brain. There few reports neural correlates in youth ASD. The current study identified systems...
Background and objectives There is a trend in the United States to maintenance dialysis initiation at higher levels of estimated GFR. This study aimed determine whether provider characteristics pre-ESRD nephrology care vascular access are independently associated with GFR initiation. Design, setting, participants, & measurements retrospective cohort used US Renal Data System data for patients who initiated 2006 (n=83,621) American Medical Association Physician Master File characteristics....
Children with traumatic brain injury (TBI) are frequently at risk of long-term impairments attention and executive functioning but these problems difficult to predict. Although deficits have been reported vary severity, age sex, prognostication outcome remains imperfect a patient-specific level. The objective this proof principle study was evaluate variety patient variables, along six brain-specific inflammatory serum protein biomarkers, as predictors cognitive following paediatric TBI....
Background and Purpose— Predictors of outcome after aneurysmal subarachnoid hemorrhage have been determined previously through hypothesis-driven methods that often exclude putative covariates require a priori knowledge potential confounders. Here, we apply data-driven approach, principal component analysis, to identify baseline patient phenotypes may predict neurological outcomes. Methods— Principal analysis was performed on 120 subjects enrolled in prospective randomized trial clazosentan...
This study examined functional changes longitudinally over 2 years in neural correlates associated with working memory youth and without autism spectrum disorder, the impact of increasing cognitive load. We used magnetic resonance imaging a visuo-spatial 1-back task four levels difficulty. A total 14 children disorder 15 typically developing (ages 7–13) were included at baseline followed up approximately later. Despite similar performance between groups, differences evident developmental...
Purpose To measure cerebellar growth in a longitudinal cohort of very preterm infants to identify early predictors subsequent brain growth. Although the cerebellum grows rapidly during late gestation, rate and variability following premature birth, effects associated injury, are largely unknown. Materials Methods In all, 105 very‐preterm born (24–32 weeks GA) were imaged using magnetic resonance imaging (MRI) at term‐equivalent, 2, 4 years age. Cerebellar total cerebral volumes estimated...