A5001357563- HIV Research and Treatment
- Multiple Sclerosis Research Studies
- Infectious Diseases and Tuberculosis
- Cytomegalovirus and herpesvirus research
- Peripheral Neuropathies and Disorders
- Bacterial Infections and Vaccines
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune Neurological Disorders and Treatments
- Artificial Intelligence in Healthcare and Education
- Complement system in diseases
- Ocular Diseases and Behçet’s Syndrome
- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- STEM Education
- Advancements in Transdermal Drug Delivery
- Pain Mechanisms and Treatments
- Vagus Nerve Stimulation Research
- Management and Optimization Techniques
- Adenosine and Purinergic Signaling
- Cardiovascular Disease and Adiposity
University of Indonesia
2015-2025
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2015-2025
Universitas Sumatera Utara
2019
Airlangga University
2019
Udayana University
2019
Universitas Gadjah Mada
2019
Sam Ratulangi University
2019
University of Brawijaya
2019
Oxford University Clinical Research Unit Indonesia
2018
Padjadjaran University
2018
Adjunctive glucocorticoids are widely used to treat human immunodeficiency virus (HIV)-associated tuberculous meningitis despite limited data supporting their safety and efficacy.
Background: Cellular metabolism is critical for the host immune function against pathogens, and metabolomic analysis may help understand characteristic immunopathology of tuberculosis. We performed targeted analyses in a large cohort patients with tuberculous meningitis (TBM), most severe manifestation tuberculosis, focusing on tryptophan metabolism. Methods: studied 1069 Indonesian Vietnamese adults TBM (26.6% HIV-positive), 54 non-infectious controls, 50 bacterial meningitis, 60...
Background and objective: The objective of this study is to clarify clinical, immunological, neuroimaging features in anti-aquaporin-4 (AQP4) antibody-positive antibody-negative Sjögren’s syndrome (SS) patients with central nervous system (CNS) involvement. Methods: Medical records MRI scans were retrospectively analyzed 22 consecutive SS CNS manifestations. Results: Seven (31.8%) positive for anti-AQP4 antibodies. frequency visual impairment was higher than (71.4% vs. 0.0%, p = 0.0008)....
Little is known about the etiology, clinical presentation, management, and outcome of central nervous system (CNS) infections in Indonesia, a country with high burden infectious diseases rising prevalence HIV.
Cognitive impairment among patients with systemic lupus erythematosus (SLE) can significantly impact quality of life (QoL). This study aimed to determine the prevalence cognitive in SLE using Montreal Assessment Indonesian version (MoCA-INA) and assess its association QoL. was a cross-sectional from outpatient clinic at Cipto Mangunkusumo Hospital, Jakarta. Data collected included patient characteristics, MoCA-INA scores, LupusQoL questionnaire, Hospital Anxiety Depression Scale (HADS)...
Little detailed knowledge is available regarding the etiology and outcome of CNS infection, particularly in HIV-infected individuals, low-resource settings.From January 2015 to April 2016, we prospectively included all adults with suspected infection a referral hospital Jakarta, Indonesia. Systematic screening HIV testing, CSF examination, neuroimaging.A total 274 patients (median age 26 years) presented after median 14 days headache (77%), fever (78%), seizures (27%), or loss consciousness...
We present a small longitudinal study of how demographic factors and persistent burdens HIV cytomegalovirus (CMV) influence cardiovascular health in young adults beginning ART an inner-city clinic Jakarta, Indonesia. ART-naïve patients [n = 67; aged 31 (19 to 48) years] were enrolled the JakCCANDO Project. Echocardiography carotid Doppler ultrasonography performed before (V0) after 3, 6, 12 months (V3–12). Antibodies reactive with CMV lysate or IE-1 protein assessed at each timepoint DNA was...
Multiple Sclerosis (MS) can affect cognitive function that might interfere with quality of life. Processing speed and memory are the most common area impairment. Cognitive evaluation in daily practice is often difficult to be performed since it needs neuropsychological expert time-consuming. Brief International Assessment for MS (BICAMS) valid practical evaluation. This study aims validate BICAMS Indonesian patients healthy controls (HC) analyse effect impairment on BICAMS, which composes...
<ns4:p><ns4:bold>Background: </ns4:bold>Tuberculous meningitis (TBM), the most severe form of tuberculosis (TB), results in death or neurological disability >50%, despite World Health Organisation recommended therapy. Current TBM regimen dosages are based on data from pulmonary TB alone. Evidence recent phase II pharmacokinetic studies suggests that high dose rifampicin (R) administered intravenously orally enhances central nervous system penetration and may reduce associated mortality....
Peripheral neuropathy is a common condition of human immunodeficiency virus (HIV)-infected patients, which often remains undetected. We assessed the performance stimulated skin wrinkling-eutectic mixture local anesthetic (SSW-EMLA) test compared with brief peripheral screening (BPNS) to detect HIV neuropathy. This cross-sectional study conducted in HIV-positive patients. A modified wrinkling grading was used assess SSW-EMLA effect. BPNS-detectable by combination severity scoring scale...
Little is known about the management and outcome of CNS infections in Indonesia (population: approximately 261 million), burden increasing as result a rapidly growing HIV epidemic. Indeed, recent study Jakarta,1 54% patients with infection were HIV-infected, vs 25% similar conducted Bandung, second largest city on Java.2 Establishing etiology important for clinical outcome, but anecdotal evidence suggests that there are major gaps management, including failure to recognize infections,...
Background: Tuberculous meningitis (TBM), the most severe form of tuberculosis (TB), results in death or neurological disability >50%, despite World Health Organisation recommended therapy. Current TBM regimen dosages are based on data from pulmonary TB alone. Evidence recent phase II pharmacokinetic studies suggests that high dose rifampicin (R) administered intravenously orally enhances central nervous system penetration and may reduce associated mortality. We hypothesize that, among...
Objective: HIV-associated sensory neuropathy (HIV-SN) remains common in HIV+ individuals receiving antiretroviral therapy (ART), even though neurotoxic drugs (e.g. stavudine) have been phased out of use. Accumulating evidence indicates that the is immune-mediated. We hypothesize chemokines produced locally skin promote migration macrophages and T cells into tissue, damaging cutaneous nerves causing HIV-SN. Design: assessed chemokine receptor expression on infiltrating CD14+ CD3+ around...
Altered T cell profiles have been linked with metrics of persistent cytomegalovirus (CMV) infections in healthy aging and older HIV patients stable on antiretroviral therapy (ART). In this study, we use CMV DNA to identify active infections, levels CMV-reactive antibody assess the burden a longitudinal study 78 young adult beginning ART Jakarta, Indonesia, <200 CD4 cells/μL. antibodies, inflammatory markers (C-reactive protein [CRP], soluble interferon-α/β receptor) phenotypes were assessed...
Chikungunya virus (CHIKV) is recognized but rarely considered as a cause of central nervous system infection in endemic areas. A total 244 patients with acute meningoencephalitis Indonesia were retrospectively tested to identify whether any CHIKV was associated neurological manifestations, especially provinces known for endemicity. Cerebrospinal fluid (CSF) and blood specimens using CHIKV-specific real-time reverse transcription polymerase chain reaction IgM ELISA, alongside panel...
<ns4:p><ns4:bold>Background: </ns4:bold>Persistent immune activation and inflammation in HIV-infection are linked to excess cardiovascular risk other non-communicable diseases. Periodic asymptomatic CMV-reactivity HIV infected patients over a lifetime may contribute non-AIDS defining morbidity. Despite undetectable levels of CMV, these continue have increased biomarkers activations. Statin administration is thought reduce subclinical atherosclerosis by decreasing LDL-C levels. It also add...
Introduction Delays in diagnosis and treatment contribute to high mortality of tuberculous meningitis (TBM). We studied TBM patient pathways including delays diagnosis, their alignment with available diagnostic services Indonesia. Methods recruited patients admitted two tertiary hospitals who started treatment. Participants or relatives were interviewed recall healthcare visits preceding also surveyed capacity for at that had been visited by least study enrolment. Results Of 175 participants...