Evelyne Kestelyn
A5018997560- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Respiratory Support and Mechanisms
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Ethics in Clinical Research
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- Long-Term Effects of COVID-19
- Mosquito-borne diseases and control
- Intensive Care Unit Cognitive Disorders
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- Diphtheria, Corynebacterium, and Tetanus
- Liver Disease Diagnosis and Treatment
- Sex work and related issues
- Reproductive Health and Contraception
- Botulinum Toxin and Related Neurological Disorders
- Global Maternal and Child Health
- Bacterial Infections and Vaccines
- Viral gastroenteritis research and epidemiology
- Reproductive tract infections research
Oxford University Clinical Research Unit
2017-2025
University of Oxford
2017-2025
META Group
2025
Analysis Group (United States)
2025
Hospital for Tropical Diseases
2018-2024
University of Rwanda
2024
Angkor Hospital for Children
2018-2023
The University of Tokyo
2022
Willis Towers Watson (United Kingdom)
2022
London School of Economics and Political Science
2022
Abstract Background Little is known about the natural history of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods We conducted a prospective study at quarantine center for disease 2019 in Ho Chi Minh City, Vietnam. enrolled quarantined people with reverse-transcription polymerase chain reaction (RT-PCR)–confirmed SARS-CoV-2 infection, collecting clinical data, travel and contact history, saliva enrollment daily nasopharyngeal/throat swabs (NTSs)...
Adjunctive glucocorticoids are widely used to treat human immunodeficiency virus (HIV)-associated tuberculous meningitis despite limited data supporting their safety and efficacy.
Adjunctive dexamethasone reduces mortality from tuberculous meningitis (TBM) but not disability, which is associated with brain infarction. We hypothesised that aspirin prevents TBM-related infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties. conducted a randomised controlled trial in HIV-uninfected adults TBM of daily 81 mg or 1000 mg, placebo, added to the first 60 days anti-tuberculosis drugs (NCT02237365). The primary safety endpoint was...
ABSTRACT Background Little is known about the natural history of asymptomatic SARS-CoV-2 infection or its contribution to transmission. Methods We conducted a prospective study at quarantine centre for COVID-19 in Ho Chi Minh City, Vietnam. enrolled quarantined people with RT-PCR-confirmed infection, collecting clinical data, travel and contact history, saliva enrolment daily nasopharyngeal throat swabs (NTS) RT-PCR testing. compared transmission potential symptomatic individuals. Results...
Abstract Background One hundred days after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Vietnam on 23 January, 270 cases were confirmed, with no deaths. We describe the control measures used by government and their relationship imported domestically acquired case numbers, aim of identifying associated successful SARS-CoV-2 control. Methods Clinical demographic data infected timing nature measures, including numbers tests quarantined individuals,...
Interpreting point-of-care lung ultrasound (LUS) images from intensive care unit (ICU) patients can be challenging, especially in low- and middle- income countries (LMICs) where there is limited training available. Despite recent advances the use of Artificial Intelligence (AI) to automate many imaging analysis tasks, no AI-enabled LUS solutions have been proven clinically useful ICUs, specifically LMICs. Therefore, we developed an AI solution that assists practitioners assessed its...
BackgroundPaediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as in children (MIS-C) emerged April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess effect of intravenous immunoglobulin or corticosteroids compared usual care on duration hospital stay for PIMS-TS and compare tocilizumab (anti-IL-6 receptor monoclonal antibody) anakinra (anti-IL-1 antagonist) those inflammation refractory initial treatment.MethodsWe...
WHO recommends treating hepatitis C infection with one of three antiviral combinations for 8-12 weeks. No randomised trials have compared these regimens, and high cure rates might be achievable shorter durations therapy. We aimed to compare sofosbuvir-daclatasvir sofosbuvir-velpatasvir, evaluate potential novel treatment strategies. conducted a multi-arm, open-label, controlled non-inferiority trial in two public hospitals Viet Nam. Adults (aged ≥18 years) chronic mild-to-moderate liver...
Introduction Adherence to combination antiretroviral therapy (cART) is vital for HIV-infected adolescents survival and quality of life. However, this age group faces many challenges remain adherent. We used multiple data sources (role-play, focus discussions (FGD), in-depth interviews (IDI)) better understand adherence barriers Rwandan adolescents. Forty-two HIV positive (ages 12–21) a selection their primary caregivers were interviewed. All perinatally-infected received ≥12 months. Topics...
Measurement of human immunodeficiency virus(HIV) incidence among female sex workers in Rwanda is a key part preparing for HIV prevention trials.HIV-negative, nonpregnant (N =397) were tested HIV-1, sexually transmitted infections, and pregnancy quarterly 12 months, again at 1-time year 2 visit. Additional women (N=156) baseline 6 to months thereafter parallel study.A total 19 participants seroconverted during follow-up,with 13 the first months. The 12-month rate (IR)was 3.5 (95% confidence...
The prevalence, incidence and persistence of human papillomavirus (HPV) types in sub-Saharan Africa are not well established. objectives the current study to describe (predictors of) epidemiology HPV among high-risk women Kigali, Rwanda. HIV-negative, were seen quarterly for one year, once Year 2. HIV serostatus, clinical, behavioral information assessed at each visit, Month 6 2, other sexually transmitted infections (STI) selected visits. prevalence was also HIV-positive, women. Prevalence...
Tuberculosis kills more people than any other bacterial infection worldwide. In tuberculous meningitis (TBM), a common functional promoter variant (C/T transition) in the gene encoding leukotriene A4 hydrolase (LTA4H), predicts pre-treatment inflammatory phenotype and response to dexamethasone HIV-uninfected individuals. The primary aim of this study is determine whether LTA4H genotype determines benefit or harm from adjunctive Vietnamese adults with TBM. secondary investigate alternative...
Background: Cryptococcal meningitis has high mortality. Flucytosine is a key treatment but expensive and rarely available. The anticancer agent tamoxifen synergistic anti-cryptococcal activity with amphotericin in vitro. It off-patent, cheap, widely We performed trial to determine its therapeutic potential. Methods: Open label randomized controlled trial. Participants received standard care – combined fluconazole for the first 2 weeks or plus 300 mg/day. primary end point was Early...
Background Hormonal contraception has been associated with a reduced risk of vaginal dysbiosis, which in turn prevalence sexually transmitted infections (STIs), including HIV. Vaginal rings are used or developed as delivery systems for contraceptive hormones and antimicrobial drugs STI HIV prevention treatment. We hypothesized that ring (CVR) containing oestrogen enhances lactobacilli-dominated microbial community despite biomass accumulation on the CVR's surface. Methods enrolled 120 women...
<ns4:p><ns4:bold>Background: </ns4:bold>Tuberculous meningitis (TBM) is the most severe form of tuberculosis. Co-infection with HIV increases risk developing TBM, complicates treatment, and substantially worsens outcome. Whether corticosteroids confer a survival benefit in HIV-infected patients TBM remains uncertain. Hepatitis common drug-induced serious adverse event associated anti-tuberculosis occurring 20% patients. The suggested concentration thresholds for stopping drugs are not...
Background: World Health Organization has called for research into predictive factors selecting persons who could be successfully treated with shorter durations of direct-acting antiviral (DAA) therapy hepatitis C. We evaluated early virological response as a means shortening treatment and explored host, viral pharmacokinetic contributors to outcome. Methods: Duration sofosbuvir daclatasvir (SOF/DCV) was determined according day 2 (D2) virologic HCV genotype (gt) 1- or 6-infected adults in...
Introduction Childhood tuberculous meningitis (TBM) is a devastating disease. The long-standing WHO recommendation for treatment 2 months of intensive phase with isoniazid (H), rifampicin (R), pyrazinamide (Z) and ethambutol (E), followed by 10 rifampicin. In 2022, released conditional that 6 intensified antituberculosis therapy (ATT) could be used as an alternative drug-susceptible TBM. However, this has never been evaluated in randomised clinical trial. Trials evaluating ATT shortening...
Objective: To identify predictors of promotion couples' HIV voluntary counseling and testing (CVCT) in Kigali, Rwanda. Design: Analysis CVCT promotional agent [influential network leaders (INLs), influential agents (INAs)], couple/invitation-level uptake. Methods: Number invitations couples tested were evaluated by INL, INA, couple/contextual factors. Multivariable logistic regression accounting for two-level clustering analyzed factors predictive testing. Results: Twenty-six INLs recruited...
<ns4:p><ns4:bold>Background: </ns4:bold>Tuberculous meningitis (TBM) is the most severe form of tuberculosis. Co-infection with HIV increases risk developing TBM, complicates treatment, and substantially worsens outcome. Whether corticosteroids confer a survival benefit in HIV-infected patients TBM remains uncertain. Hepatitis common drug-induced serious adverse event associated anti-tuberculosis occurring 20% patients. The suggested concentration thresholds for stopping drugs are not...
An endotracheal tube cuff pressure between 20 and 30 cmH2O is recommended to prevent ventilator-associated respiratory infection (VARI). We aimed evaluate whether continuous control (CPC) was associated with reduced VARI incidence compared intermittent CPC.We conducted a multicenter open-label randomized controlled trial in intensive care unit (ICU) patients within 24 hours of intubation Vietnam. Patients were randomly assigned 1:1 receive either CPC using an automated electronic device or...
Gestational Diabetes Mellitus (GDM) is common in South East Asia, occurring at relatively lean Body Mass Index (BMI). Outside pregnancy, cardiometabolic risks increase lower BMI Asian populations, justifying Asian-specific thresholds for overweight and obesity. We aimed to explore the effects of GDM obesity on perinatal outcomes using a WHO expert consultation-recommended definition obesity.This secondary analysis prospective, hospital-based, cohort study Ho Chi Minh City. Participants were...
To evaluate linkage-to-care, sexual behavior change, and psychosocial experiences among newly HIV-diagnosed female sex workers (FSWs) in Rwanda.FSWs (n = 800) with unknown serostatus were screened for HIV during 2007/2008. Women testing positive 192) referred to care asked return interviews laboratory 12-36 months postdiagnosis. One hundred fourty-one women (73%) returned the postdiagnosis visit.Median CD4 count at diagnosis was 460 cells per microliter [interquartile range (IQR): 308-628],...
Although sex work can bring significant economic benefit there are serious downsides, not least vulnerability to adverse sexual health outcomes. Focus-groups discussions and in-depth interviews were conducted with 70 female workers explore the context in which they started work, their motivations leave, experiences of trying leave. The pathway becoming a worker was underscored by poverty, disruptive events leading increasing increasingly difficult life choices. A sizeable minority women...