Le Nguyen Truc Nhu
A5003011941- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Animal Virus Infections Studies
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Influenza Virus Research Studies
- COVID-19 diagnosis using AI
- Viral Infections and Vectors
- Whipple's Disease and Interleukins
- Viral Infections and Outbreaks Research
- T-cell and Retrovirus Studies
- COVID-19 and Mental Health
- Herpesvirus Infections and Treatments
- Bacillus and Francisella bacterial research
- Nuts composition and effects
- Immune responses and vaccinations
- Cytomegalovirus and herpesvirus research
- Virology and Viral Diseases
Oxford University Clinical Research Unit
2013-2024
Hospital for Tropical Diseases
2010-2020
Seonam University
2020
Seoul Metropolitan Government
2020
Seoul National University
2020
Boramae Medical Center
2020
Center for Disease Control
2020
National Institute Of Hygiene And Epidemiology
2020
Children's Hospital
2018
University of Oxford
2018
Abstract Background Little is known about the natural history of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods We conducted a prospective study at quarantine center for disease 2019 in Ho Chi Minh City, Vietnam. enrolled quarantined people with reverse-transcription polymerase chain reaction (RT-PCR)–confirmed SARS-CoV-2 infection, collecting clinical data, travel and contact history, saliva enrollment daily nasopharyngeal/throat swabs (NTSs)...
ABSTRACT Background Little is known about the natural history of asymptomatic SARS-CoV-2 infection or its contribution to transmission. Methods We conducted a prospective study at quarantine centre for COVID-19 in Ho Chi Minh City, Vietnam. enrolled quarantined people with RT-PCR-confirmed infection, collecting clinical data, travel and contact history, saliva enrolment daily nasopharyngeal throat swabs (NTS) RT-PCR testing. compared transmission potential symptomatic individuals. Results...
Abstract Background One hundred days after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Vietnam on 23 January, 270 cases were confirmed, with no deaths. We describe the control measures used by government and their relationship imported domestically acquired case numbers, aim of identifying associated successful SARS-CoV-2 control. Methods Clinical demographic data infected timing nature measures, including numbers tests quarantined individuals,...
Abstract Hand, foot and mouth disease (HFMD) is a major public health issue in Asia has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected 514/2,230 (23%) of HFMD patients admitted to 3 hospitals southern Vietnam during 2011–2015. Of these patients, 93 (18%) had severe HFMD. Phylogenetic analysis 98 genome sequences revealed they belonged cluster A been circulating for 2 years before emergence. CV-A6 movement among localities within occurred frequently, whereas viral across...
Abstract We report a superspreading event of severe acute respiratory syndrome coronavirus 2 infection initiated at bar in Vietnam with evidence symptomatic and asymptomatic transmission, based on ministry health reports, patient interviews, whole-genome sequence analysis. Crowds enclosed indoor settings poor ventilation may be considered high risk for transmission.
Since January 2018, over 53,000 hospitalisations and six deaths due to hand, foot mouth disease (HFMD) have occurred across Vietnam with most cases from September onward. In a large tertiary referral hospital, Ho Chi Minh City, enterovirus A71 subgenogroup C4 was predominant, while B5 only sporadically detected. The re-emergence of after causing severe HFMD outbreak > 200 in 2011–12 among susceptible young children raises concern another impending outbreak.
Hand, foot and mouth disease (HFMD) continues to challenge Asia with pandemic potential. In Vietnam, there have been two major outbreaks occurring during 2011–2012 (>200,000 hospitalizations >200 deaths) more recently in 2018 (>130,000 17 deaths). Given the high burden complex epidemic dynamics of HFMD, synthesizing its clinical epidemiological data remains essential inform development appropriate interventions design public health measures. We report results a hospital-based study conducted...
Background To date, little is known about the initial spread and response to 2009 pandemic of novel influenza A ("2009 H1N1") in tropical countries. Here, we analyse early progression epidemic from 26 May until establishment community transmission second half July Ho Chi Minh City (HCMC), Vietnam. In addition, present detailed systematic viral clearance data on 292 isolated treated patients first three cases selection resistant virus during treatment Methods Findings Data sources included...
Japanese encephalitis virus was detected by deep sequencing for the first time in urine of a 16-year-old boy with encephalitis. Seroconversion and polymerase chain reaction analysis confirmed metagenomics finding. Urine is useful diagnosis flaviviral encephalitis, whereas can be panpathogen assay life-threatening infectious diseases.
Meningoencephalitis is a devastating disease worldwide. Current diagnosis fails to establish the cause in ≥50% of patients. Metagenomic next-generation sequencing (mNGS) has emerged as pan-pathogen assays for infectious diseases diagnosis, but few studies have been conducted resource-limited settings. We assessed performance mNGS cerebrospinal fluid (CSF) 66 consecutively treated adults with meningoencephalitis tertiary referral hospital Vietnam, setting. All results were confirmed by...
ABSTRACT. We studied the immunogenicity of Oxford-AstraZeneca vaccine in health-care workers a major infectious diseases hospital Vietnam. measured neutralizing antibodies before and 14 days after each dose, at day 28 month 3 dose 1. A total 554 (136 men 418 women; age range, 22–71 years; median age, 36 years) participated with study. Of 144 participants selected for follow-up 1, 104 94 gave blood antibody measurement weeks 6 8, respectively. The window time between two doses was weeks. At...
Abstract We report on a 2023 outbreak of severe hand, foot, and mouth disease in southern Vietnam caused by an emerging lineage enterovirus A71 subgenogroup B5. Affected children were significantly older than those reported during previous outbreaks. The virus should be closely monitored to assess its potential for global dispersal.
Abstract The rapid spread of coronavirus disease 2019 (COVID-19) raises concern about a global pandemic. Knowledge the duration viral shedding remains important for patient management and infection control. We report detection in throat rectum COVID-19 treated at Hospital Tropical Diseases Ho Chi Minh City, Vietnam. Despite clinical recovery, SARS-CoV-2 RNA remained detectable by real time RT-PCR rectal swabs until day 11 18 hospitalization, respectively. Because live has been successfully...
As avian influenza A(H5N1) viruses continue to circulate in Asia and Africa, global concerns of an imminent pandemic persist. Recent experimental studies suggest that efficient transmission between humans current H5N1 only requires a few genetic changes. An essential step is alteration the virus hemagglutinin from preferential binding receptors for recognition human present upper airway. We have identified receptor-binding changes which emerged during infection humans, due single amino acid...
Community-acquired (CA) sepsis is a major public health problem worldwide, yet the etiology remains unknown for >50% of patients. Here we applied metagenomic next-generation sequencing (mNGS) to characterize human virome in 492 clinical samples (384 sera, 92 pooled nasal and throat swabs, 10 stools, 6 cerebrospinal fluid samples) from 386 patients (213 adults 173 children) presenting with CA who were recruited hospitals across Vietnam between 2013 2015.
W ith a population exceeding 630 million (8% of the global population), ten member states Association Southeast Asian Nations (ASEAN) accounted for approximately 61 (7.9%) COVID-19 cases and 808 166 (11.6%) deaths, with case fatality rate (CFR) 1.3% by end 2023 [1].The actual figures are certain to be at least several-fold higher, estimates suggesting an excess mortality 1.2 in first two years pandemic.Despite World Health Organization's (WHO) 4 May declaration that coronavirus disease 2019...
Abstract Background Hand, foot, and mouth disease (HFMD) has become a major public health concern in the Asia-Pacific region. Knowledge of its economic burden is essential for policy makers prioritizing development implementation interventions. Methods A multi-hospital-based study was prospectively conducted at 3 hospitals Ho Chi Minh City, Vietnam, during 2016–2017. Data on direct productivity costs were collected alongside clinical information samples demographic from participants. Results...
We analyzed 1,303 SARS-CoV-2 whole-genome sequences from Vietnam, and found the Alpha Delta variants were responsible for a large nationwide outbreak of COVID-19 in 2021. The variant was confined to AY.57 lineage caused >1.7 million infections >32,000 deaths. Viral transmission strongly affected by nonpharmaceutical interventions.
Hand, foot and mouth disease (HFMD) is highly prevalent in the Asia Pacific region, particularly Vietnam. To develop effective interventions efficient vaccination programs, we inferred age-time-specific transmission patterns of HFMD serotypes enterovirus A71 (EV-A71), coxsackievirus A6 (CV-A6), A10 (CV-A10), A16 (CV-A16) Ho Chi Minh City, Vietnam from a case data collected during 2013-2018 serological survey 2015 2017. We proposed catalytic model framework with good adaptability to...
Abstract The first nationwide outbreak of COVID-19 in Vietnam started late April 2021 and was caused almost exclusively by a single Delta lineage, AY.57. In early 2022, multiple Omicron variants co-circulated with quickly became dominant. co-circulation happened leading to possibility co-infection recombination events which can be revealed viral genomic data. From January October total 1028 RNA samples out 4852 positive (Ct < 30) were sequenced the long pooled amplicons method on Illumina...
ObjectivesCentral nervous system (CNS) infections are common causes of morbidity and mortality worldwide. We aimed to discover protein biomarkers that could rapidly accurately identify the likely cause infections, essential for clinical management improving outcome.MethodsWe applied liquid chromatography tandem mass spectrometry on 45 cerebrospinal fluid (CSF) samples from a cohort adults with without CNS potential diagnostic biomarkers. then validated performance selected biomarker...
Abstract Central nervous system (CNS) infection is a serious neurologic condition, although the etiology remains unknown in >50% of patients. We used metagenomic next-generation sequencing to detect viruses 204 cerebrospinal fluid (CSF) samples from patients with acute CNS who were enrolled Vietnam hospitals during 2012–2016. detected 8 viral species 107/204 (52.4%) CSF samples. After virus-specific PCR confirmation, detection rate was lowered 30/204 (14.7%). Enteroviruses most common (n =...