Nguyen To Anh
A5054909412- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- RNA and protein synthesis mechanisms
- Animal Virus Infections Studies
- Herpesvirus Infections and Treatments
- Bacillus and Francisella bacterial research
- T-cell and Retrovirus Studies
- Gut microbiota and health
- COVID-19 epidemiological studies
- Hepatitis B Virus Studies
- Virology and Viral Diseases
- Viral Infections and Outbreaks Research
- Parasite Biology and Host Interactions
- Plant Virus Research Studies
- Poxvirus research and outbreaks
- Hepatitis C virus research
- Genomics and Phylogenetic Studies
- Whipple's Disease and Interleukins
- Viral-associated cancers and disorders
Oxford University Clinical Research Unit
2015-2024
Children's Hospital
2018
University of Oxford
2018
National Institutes of Health
2018
Mahidol Oxford Tropical Medicine Research Unit
2018
Blood Systems Research Institute
2018
University of California, San Francisco
2018
Washington University in St. Louis
2017
Witten/Herdecke University
2016-2017
Hospital for Tropical Diseases
2015-2017
Abstract Hand, foot and mouth disease (HFMD) is a major public health issue in Asia has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected 514/2,230 (23%) of HFMD patients admitted to 3 hospitals southern Vietnam during 2011–2015. Of these patients, 93 (18%) had severe HFMD. Phylogenetic analysis 98 genome sequences revealed they belonged cluster A been circulating for 2 years before emergence. CV-A6 movement among localities within occurred frequently, whereas viral across...
Hand, foot and mouth disease (HFMD) continues to challenge Asia with pandemic potential. In Vietnam, there have been two major outbreaks occurring during 2011–2012 (>200,000 hospitalizations >200 deaths) more recently in 2018 (>130,000 17 deaths). Given the high burden complex epidemic dynamics of HFMD, synthesizing its clinical epidemiological data remains essential inform development appropriate interventions design public health measures. We report results a hospital-based study conducted...
Meningoencephalitis is a devastating disease worldwide. Current diagnosis fails to establish the cause in ≥50% of patients. Metagenomic next-generation sequencing (mNGS) has emerged as pan-pathogen assays for infectious diseases diagnosis, but few studies have been conducted resource-limited settings. We assessed performance mNGS cerebrospinal fluid (CSF) 66 consecutively treated adults with meningoencephalitis tertiary referral hospital Vietnam, setting. All results were confirmed by...
ABSTRACT. We studied the immunogenicity of Oxford-AstraZeneca vaccine in health-care workers a major infectious diseases hospital Vietnam. measured neutralizing antibodies before and 14 days after each dose, at day 28 month 3 dose 1. A total 554 (136 men 418 women; age range, 22–71 years; median age, 36 years) participated with study. Of 144 participants selected for follow-up 1, 104 94 gave blood antibody measurement weeks 6 8, respectively. The window time between two doses was weeks. At...
Abstract We report on a 2023 outbreak of severe hand, foot, and mouth disease in southern Vietnam caused by an emerging lineage enterovirus A71 subgenogroup B5. Affected children were significantly older than those reported during previous outbreaks. The virus should be closely monitored to assess its potential for global dispersal.
Enterovirus A71 (EV-A71) has emerged as the most important cause of large outbreaks severe and sometimes fatal hand, foot mouth disease (HFMD) across Asia-Pacific region. EV-A71 have been associated with (sub)genogroup switches, accompanied by recombination events. Understanding population dynamics is therefore essential for understanding this emerging infection, may provide pivotal information vaccine development. Despite public health burden EV-A71, relatively few complete-genome sequences...
Community-acquired (CA) sepsis is a major public health problem worldwide, yet the etiology remains unknown for >50% of patients. Here we applied metagenomic next-generation sequencing (mNGS) to characterize human virome in 492 clinical samples (384 sera, 92 pooled nasal and throat swabs, 10 stools, 6 cerebrospinal fluid samples) from 386 patients (213 adults 173 children) presenting with CA who were recruited hospitals across Vietnam between 2013 2015.
We utilized polymerase chain reaction (PCR) to demonstrate that Angiostrongylus cantonensis was responsible for 67.3% of 55 cases eosinophilic meningitis from a cohort 1,690 adult patients with CNS infection at tertiary hospital in southern Vietnam. Longer duration illness, depressed consciousness, and peripheral blood eosinophilia were associated PCR positivity.
Hand foot and mouth disease (HFMD) is a of public health importance across the Asia-Pacific region. The caused by enteroviruses (EVs), in particular enterovirus A71 (EV-A71). In EV-A71-associated HFMD, infection sometimes associated with severe manifestations including neurological involvement fatal outcome. availability robust diagnostic assay to distinguish EV-A71 from other EVs important for patient management outbreak response. We developed validated an internally controlled one-step...
We analyzed 1,303 SARS-CoV-2 whole-genome sequences from Vietnam, and found the Alpha Delta variants were responsible for a large nationwide outbreak of COVID-19 in 2021. The variant was confined to AY.57 lineage caused >1.7 million infections >32,000 deaths. Viral transmission strongly affected by nonpharmaceutical interventions.
Hand, foot and mouth disease (HFMD) is highly prevalent in the Asia Pacific region, particularly Vietnam. To develop effective interventions efficient vaccination programs, we inferred age-time-specific transmission patterns of HFMD serotypes enterovirus A71 (EV-A71), coxsackievirus A6 (CV-A6), A10 (CV-A10), A16 (CV-A16) Ho Chi Minh City, Vietnam from a case data collected during 2013-2018 serological survey 2015 2017. We proposed catalytic model framework with good adaptability to...
Abstract The first nationwide outbreak of COVID-19 in Vietnam started late April 2021 and was caused almost exclusively by a single Delta lineage, AY.57. In early 2022, multiple Omicron variants co-circulated with quickly became dominant. co-circulation happened leading to possibility co-infection recombination events which can be revealed viral genomic data. From January October total 1028 RNA samples out 4852 positive (Ct < 30) were sequenced the long pooled amplicons method on Illumina...
Abstract Central nervous system (CNS) infection is a serious neurologic condition, although the etiology remains unknown in >50% of patients. We used metagenomic next-generation sequencing to detect viruses 204 cerebrospinal fluid (CSF) samples from patients with acute CNS who were enrolled Vietnam hospitals during 2012–2016. detected 8 viral species 107/204 (52.4%) CSF samples. After virus-specific PCR confirmation, detection rate was lowered 30/204 (14.7%). Enteroviruses most common (n =...
Abstract We studied the development and persistence of neutralising antibodies against SARS-CoV-2 ancestral strain, Delta Omicron (BA.1 BA.2) variants in Vietnamese healthcare workers (HCWs) up to 15 weeks after booster vaccination. included 47 HCWs with different pre-existing immune statuses (group 1 (G1): n=21, group 2 (G2): n=26 without prior breakthrough variant infection, respectively). The study participants had completed primary immunisation ChAdOx1-S vaccination BNT162b2....
We investigated enterovirus A71-associated hand, foot and mouth disease in Vietnam found that, after replacing subgenogroup C4 2013, B5 remained the leading cause of this disease. In contrast with previous observations, switch did not result an explosive outbreak, evolution was driven by negative selection.
We report human pegivirus 2 (HPgV-2) infection in Vietnam. detected HPgV-2 some patients with hepatitis C virus/HIV co-infection but not HIV or A, B, virus infection, nor healthy controls. strains Vietnam are phylogenetically related to global strains.
Background: Hand, Foot and Mouth Disease (HFMD) is a major public health concern in the Asia-Pacific region. Most recent HFMD outbreaks have been caused by enterovirus A71 (EV-A71), coxsackievirus A16 (CVA16), CVA10, CVA6. There has no report regarding epidemiology genetic diversity of CVA16 Vietnam. Such knowledge critical to inform development intervention strategies. Materials Methods: From 2011 2017, clinical samples were collected from in- outpatients enrolled research program conducted...
<ns4:p><ns4:bold>Background: </ns4:bold>Since 1962, enterovirus D68 (EV-D68) has been implicated in multiple outbreaks and sporadic cases of respiratory infection worldwide, especially the USA Europe with an increasing frequency between 2010 2014. We describe detection, associated clinical features molecular characterization EV-D68 central southern Viet Nam 2009 2015.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> Enterovirus/rhinovirus PCR positive or CSF samples taken from children adults...
<ns4:p><ns4:bold>Background: </ns4:bold>Since 1962, enterovirus D68 (EV-D68) has been implicated in multiple outbreaks and sporadic cases of respiratory infection worldwide, especially the USA Europe with an increasing frequency between 2010 2014. We describe detection, associated clinical features molecular characterization EV-D68 central southern Viet Nam 2009 2015.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> Enterovirus/rhinovirus PCR positive or CSF samples taken from children adults...
Background: Data on breakthrough SARS-CoV-2 Delta variant infections are limited.Methods: We studied among healthcare workers of a major infectious diseases hospital in Vietnam. collected demographics, vaccination history and results PCR diagnosis alongside clinical data. measured (neutralizing) antibodies at diagnosis, week 1, 2 3 after diagnosis. sequenced the viruses using ARTIC protocol.Findings: Between 11th–25th June 2021 (week 7–8 dose 2), 69 were tested positive for SARS-CoV-2. 62...
Abstract Background Data on the dynamics and persistence of humoral immunity against SARS-CoV-2 after primary vaccination with two-dose inactivated vaccine (CoronaVac) are limited. This study evaluated sequential effects prior infection, heterologous boosting mRNA-1273 (Moderna), occurrence Omicron vaccine-breakthrough infection (VBI) thereafter. Methods We anti-spike IgG (Abbott) neutralising (cPASS/GenScript) antibody (nAb) titers up to one year boost in two-dose-CoronaVac-primed...