A5062638586- Blood Pressure and Hypertension Studies
- Systemic Sclerosis and Related Diseases
- Thermoregulation and physiological responses
- Cardiovascular Syncope and Autonomic Disorders
- Infrared Thermography in Medicine
- Heart Rate Variability and Autonomic Control
- Nutritional Studies and Diet
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Dermatologic Treatments and Research
- Hemodynamic Monitoring and Therapy
- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
- Pharmacology and Obesity Treatment
- Electrolyte and hormonal disorders
- Inflammatory mediators and NSAID effects
- Cardiovascular Health and Disease Prevention
- Antioxidant Activity and Oxidative Stress
- Cardiac Imaging and Diagnostics
- Ultrasound and Cavitation Phenomena
- Skin Diseases and Diabetes
- Autoimmune Neurological Disorders and Treatments
- Anesthesia and Pain Management
- Adrenal Hormones and Disorders
Oxford University Clinical Research Unit
2024-2025
Yokohama National University
2021
Radboud University Nijmegen
1987-2011
Maastricht University
2007
General Department of Preventive Medicine
1995-1996
Janssen (Belgium)
1995
This study was performed to compare continuous Finapres (FIN) and intrabrachial (IAP) blood pressure in healthy elderly volunteers. Fifteen subjects (age 71 83) without cardiovascular disease an intraarterial mean (range) systolic diastolic of 162 (122 195) 73 (62 88) mm Hg, respectively, participated the study. A 10-min head-up tilt, 10 min active standing, a 15-sec Valsalva, 5-min mental arithmetic were random order. Beat-to-beat values systolic, diastolic, arterial analyzed. At rest, FIN...
In an open triple crossover study in 10 patients with mild to moderate essential hypertension the influence was investigated of adding indomethacin 50 mg, naproxen 250 or sulindac 200 each twice daily for four weeks, diuretic treatment hydrochlorothiazide mg a day. After two weeks9 slight increase blood pressure observed, whereas both and tended enhance antihypertensive effect hydrochlorothiazide. however, effects all three drugs on appeared be blunted. Furthermore, body weight increased...
Abstract We report on a 2023 outbreak of severe hand, foot, and mouth disease in southern Vietnam caused by an emerging lineage enterovirus A71 subgenogroup B5. Affected children were significantly older than those reported during previous outbreaks. The virus should be closely monitored to assess its potential for global dispersal.
Abstract Until now the clinical criteria for diagnosis of vascular parkinsonism (VP) have been disputed. The purpose present study is to investigate whether quantitative gait analysis can differentiate between pattern patients with VP and idiopathic Parkinson's disease (PD). Twelve VP, 12 PD, 10 neurologically nondiseased controls were examined by analysis. Patients having a similar velocity stride length, showed relatively preserved arm swing markedly more anteflexion in shoulder on forward...
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. Early detection crucial, yet reliable biomarkers are limited. Methylated SEPT9 (mSEPT9) has emerged as promising biomarker for...
To investigate the influence of hormonal status on skin vascular reactivity, 18 males, women using oral contraceptives (oc), 17 premenopausal, and postmenopausal were studied. Finger temperature (FST, in degrees C) laser Doppler flux (LDF, perfusion units) measured during heating (45 C water bath) cooling (15 followed by a subsequent recovery period. Maximal heat-induced vasodilation was significantly higher oc premenopausal when compared with males. During cooling, FST LDF males women,...
In 12 healthy male volunteers (27-53 yr), a placebo-controlled randomized double blind cross-over trial was performed to study the effect of intravenous injection 0.25, 0.5, 1, 2, 4, and 6 mg draflazine (a selective nucleoside transport inhibitor) on hemodynamic neurohumoral parameters ex vivo inhibition. We hypothesized that an dosage without would still be able augment forearm vasodilator response intraarterially infused adenosine. Heart rate (electrocardiography), systolic blood pressure...
Systemic hyperinsulinaemia induces vasodilatation in human skeletal muscle. This effect is gradual onset, and at low insulin levels not maximal until least 3 h. To investigate whether the vasodilator response to results from a direct vascular effect, we infused directly into cannulated brachial artery (perfused forearm technique) total of 30 experiments 20 healthy, lean, normotensive volunteers. Local, intra‐arterial, infusion (180 min, 0.3 mU dL −1 volume min , n = 15, venous concentration...
In 99 patients with primary Raynaud's phenomenon (RP), in 97 secondary RP and 101 healthy subjects, finger skin temperature laser Doppler flux were measured before, during after immersion of the hand a 16 degrees C water bath. We determined baseline value, values at end cooling period 12 20 min recovery, percentual decrease mean cooling, recovery whole test. Most parameters significantly lower females than males all three groups. There no significant differences between either or RP. both...
Background:Masked hypertension (MH) is defined as a normal blood pressure in the physician's office and an elevated when measured out-of-office. The cause of MH may be termed masked effect (MHE), not restricted to blood-pressure (BP) values around thresholds for BP. We investigated prevalence persistence MHE patients who were being treated high BP had been followed period 1 year.
In this double‐blind two period crossover study, we investigated the effect of indomethacin and sulindac on blood pressure in 25 hypertensive patients being treated with hydrochlorothiazide. The study consisted seven 4 week periods. first last took placebos, two, four six they were hydrochlorothiazide 50 mg once daily alone, third fifth was given combination either twice or 200 random order. Blood pressure, measured by sphygmomanometer arteriosonde, body weight determined every 2 weeks....
Recently it has been demonstrated that blood pressure in the elderly decreases after a meal. To evaluate influence of antihypertensive treatment on postprandial reduction elderly, effects breakfast (405 kcal) and heart rate were studied 15 healthy normotensive subjects (mean age 79.5 +/- 6.0 years), 10 hypertensive 80.2 5.7 years) 22 71.4 5.0 treated with medication (diuretics, beta-blockers, vasodilators). In three groups there was fall mean arterial 9.3 1.9%, 13.8 1.9% 7.9 1.3%,...
Prion diseases are a group of neurodegenerative affecting wide range mammalian species, including humans. During the course disease, abnormally folded scrapie prion protein (PrP Sc ) accumulates in central nervous system where it causes neurodegeneration. In disorders, diverse spectrum illnesses exists because presence different isoforms PrP they occupy distinct conformational states called strains. Strains biochemically distinguished by characteristic three-band immunoblot pattern, defined...
Measurements of Laser Doppler flow were performed on the fingertip during heating in a group normals and patients with different types Raynaud's phenomenon. During 24 was distinguished from 29 primary patients. A 17 secondary phenomenon due to scleroderma 8 arteriographically proven severe vascular occlusive disease fingers showed significantly lower response comparison two above-mentioned groups. Patients or without slight trophic skin lesions identified. In maximal vasodilation inversely...
In order to test the hypothesis that chronically elevated serum gastrin levels induce hypercalcitoninaemia, we have measured calcitonin in patients with chronic hypergastrinaemia. Basal concentrations were found be 2 of 23 Zollinger-Ellison syndrome, but not 16 hypergastrinaemia due achlorhydria or a single patient primary antral origin. Both hypercalcitoninaemia (0.31 and 0.79 ng/ml) had multiple endocrine adenomatosis type 1, no medullary carcinoma thyroid. The these does seem related...