A5038761233- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Infant Development and Preterm Care
- COVID-19 Clinical Research Studies
- Neonatal and Maternal Infections
- Pediatric Hepatobiliary Diseases and Treatments
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Bacterial Identification and Susceptibility Testing
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Breastfeeding Practices and Influences
- Intensive Care Unit Cognitive Disorders
- Respiratory viral infections research
- COVID-19 and healthcare impacts
- Infant Health and Development
- Congenital Diaphragmatic Hernia Studies
- Child and Adolescent Health
- HIV, Drug Use, Sexual Risk
- Respiratory Support and Mechanisms
- Gut microbiota and health
- Sex work and related issues
- Rabies epidemiology and control
Homerton University Hospital NHS Foundation Trust
2014-2024
Queen Mary University of London
2011-2024
Homerton University Hospital
2011-2024
Genomics (United Kingdom)
2021-2024
University College London
2024
Institute of Child Health
2024
Imperial College Healthcare NHS Trust
2024
Imperial College London
2024
Universidad de Londres
2024
Great Ormond Street Hospital
2024
BackgroundPaediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as in children (MIS-C) emerged April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess effect of intravenous immunoglobulin or corticosteroids compared usual care on duration hospital stay for PIMS-TS and compare tocilizumab (anti-IL-6 receptor monoclonal antibody) anakinra (anti-IL-1 antagonist) those inflammation refractory initial treatment.MethodsWe...
Importance Although whole-body hypothermia is widely used after mild neonatal hypoxic-ischemic encephalopathy (HIE), safety and efficacy have not been evaluated in randomized clinical trials (RCTs), to our knowledge. Objective To examine the effect of 48 72 hours HIE on cerebral magnetic resonance (MR) biomarkers. Design, Setting, Participants This open-label, 3-arm RCT was conducted between October 31, 2019, April 28, 2023, with masked outcome analysis. were neonates at 6 tertiary intensive...
Abstract Infection and infection-related complications are important causes of death morbidity following preterm birth. Despite this risk, there is limited understanding the development immune system in those born prematurely, how influenced by perinatal factors. Here we prospectively longitudinally follow a cohort babies before 32 weeks gestation. We demonstrate that babies, including extremely prematurely (<28 weeks), capable rapidly acquiring some adult levels functionality, which...
Objective. To review the epidemiology of coagulase-negative staphylococci (CoNS) in England over recent 12 year period. Methods. Laboratory-confirmed CoNS reported from sterile sites patients to UK Health Security Agency (UKHSA) between 2010 and 2021 were extracted national laboratory database analysed. Results. Overall, 668 857 episodes reported. Unspeciated accounted for 56 % (374 228) episodes, followed by Staphylococcus epidermidis (26 %; 174 050), S. hominis (6.5 43 501) capitis (3.9 25...
Infants born at 34(+0) to 36(+6) weeks gestation are defined as 'late preterm' infants. It is not clear whether these babies can be managed on the postnatal ward (PNW) or routinely need admitted neonatal unit after birth.To conduct a national survey of admission practice for late preterm and low birth weight infants directly PNW in England.All units were identified from Standardised Electronic Neonatal Database (SEND). Individual contacted data collected their practice.All 180 England...
Abstract Background Intestinal dysbiosis is implicated in the origins of necrotising enterocolitis and late-onset sepsis preterm babies. However, effect modulators bacterial growth ( e.g. antibiotics) upon developing microbiome not well-characterised. In this prospectively-recruited, retrospectively-classified, case–control study, high-throughput 16S rRNA gene sequencing was combined with contemporaneous clinical data collection, to assess within-subject relationship between antibiotic...
Aim: Infants with viral bronchiolitis are often hospitalised a proportion requiring respiratory support. The aim of this review was to examine the use nasal prong continuous positive airway pressure (CPAP) as management strategy for infants diagnosis bronchiolitis, who required stabilisation and transport tertiary centre. Method: A retrospective audit CPAP during between January 2003 June 2007. Results: Nasal initiated in 54 51 these (34 ex‐preterm, 17 term) subsequently continuing on...
Probiotic administration to preterm infants has the potential prevent necrotising enterocolitis (NEC). Data from randomised controlled trials (RCT) are conflicting but meta-analyses seem support this intervention. To date, these analyses have not focused on surgical NEC. We aimed determine effect of probiotic prevention NEC.A systematic review RCTs was performed. Studies were included if RCT outcomes any (1) Bell's stage 3 NEC; (2) surgery for and (3) deaths attributable Article selection...
Objective There is a lack of UK guidance regarding routine use probiotics in preterm infants to prevent necrotising enterocolitis, late-onset sepsis and death. As practices can vary, we aimed determine the current usage within neonatal units UK. Design setting Using NeoTRIPS, trainee-led research network, an online survey was disseminated all service levels England, Scotland, Northern Ireland Wales 2022. Trainees were requested complete one per unit probiotic administration. Results 161 188...
Mild hypoxic ischemic encephalopathy is associated with sub optimal cognition and learning difficulties at school age. Although whole-body hypothermia reduces death disability after moderate or severe in high-income countries, the safety efficacy of mild not known. The cooling (COMET) trial will examine if improves cognitive development neonates encephalopathy.
Intestinal dysbiosis is implicated in the pathogenesis of necrotising enterocolitis and late-onset sepsis preterm babies. The provision non-invasive positive pressure ventilation a common clinical intervention babies, may be hypothesised to adversely affect intestinal bacterial growth, through increased aerophagia induction hyperoxic environment; however this relationship has not been previously well characterised.
Objective Staphylococcus capitis , a coagulase-negative staphylococci (CoNS) species, has been increasingly detected from UK sterile site samples and caused neonatal unit outbreaks worldwide. We compared survival to discharge 30-day mortality for the detection of S. versus other CoNS species. Methods In this retrospective case–control study, we included hospitalised infants with any species normally body up 90 days age. linked English laboratory reports Second Generation Surveillance System...
Aim Viral bronchiolitis is the most common lower respiratory tract infection in children less than 12 months of age. Prematurity an independent risk factor for disease severity. Many infected infants require hospitalisation and those living regional centres frequently transfer to metropolitan hospitals capable providing assisted ventilation. Method We reviewed with transported by V ictorian N ewborn E mergency T ransport S ervice between J anuary 2003 une 2007. compared clinical presentation...
Severe acute respiratory syndrome coronavirus 2 infections are uncommon in newborn infants. This report describes possible utero transmission of the B.1.1.7 (alpha) variant a preterm infant born at 31 weeks' gestational age who presented with severe disease. The was treated high-frequency oscillatory ventilation, antiviral medications, and corticosteroids transitioned to noninvasive support on day 33. By 63, she off positive pressure breathing room air discharged from hospital 70. She...