A5039878003- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Urinary Tract Infections Management
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- COVID-19 and healthcare impacts
- Pharmaceutical and Antibiotic Environmental Impacts
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Mycotoxins in Agriculture and Food
- Bacterial biofilms and quorum sensing
- Nosocomial Infections in ICU
- COVID-19 epidemiological studies
- Enterobacteriaceae and Cronobacter Research
- SARS-CoV-2 detection and testing
- Emergency and Acute Care Studies
- Sepsis Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Escherichia coli research studies
- Microscopic Colitis
- Neonatal and Maternal Infections
- Respiratory viral infections research
UK Health Security Agency
2021-2025
Public Health England
2014-2023
National Institute for Health Research
2021
Imperial College London
2018-2019
NIHR Imperial Biomedical Research Centre
2019
University of Sheffield
2018
MRC London Institute of Medical Sciences
2018
Vifor Pharma (United Kingdom)
2013
Health Protection Scotland
2012
Cranfield University
2002-2010
The omicron variant (B.1.1.529) of SARS-CoV-2 has demonstrated partial vaccine escape and high transmissibility, with early studies indicating lower severity infection than that the delta (B.1.617.2). We aimed to better characterise relative by assessing risk hospital attendance, admission, or death in a large national cohort.
Nowadays, six types of acquired vancomycin resistance in enterococci are known; however, only VanA and to a lesser extent VanB widely prevalent. Various genes encode these typically associated with mobile genetic elements which allow spread clonally laterally. The major reservoir is Enterococcus faecium; vancomycin-resistant faecalis still rare. Population analysis E. faecium has revealed distinct subpopulation hospital-acquired strain types, can be differentiated by molecular typing methods...
The SARS-CoV-2 delta (B.1.617.2) variant was first detected in England March, 2021. It has since rapidly become the predominant lineage, owing to high transmissibility. is suspected that associated with more severe disease than previously dominant alpha (B.1.1.7) variant. We aimed characterise severity of compared by determining relative risk hospital attendance outcomes.
The control of Clostridium difficile infections is an international clinical challenge. incidence C in England declined by roughly 80% after 2006, following the implementation national policies; we tested two hypotheses to investigate their role this decline. First, if infection declines were driven reductions use particular antibiotics, then caused resistant isolates should decline faster than that susceptible across multiple genotypes. Second, improvements hospital control, transmitted...
Abstract Background Respiratory syncytial virus (RSV) may contribute to a substantial volume of antibiotic prescriptions in primary care. However, data on the type antibiotics prescribed for such infections are only available children <5 years UK. Understanding contribution RSV prescribing would facilitate predicting impact preventative measures use and resistance. The objective this study was estimate proportion English general practice attributable by age class. Methods Generalized...
Aims: Comparisons were made of the effect water activity (aw 0·99–0·85), temperature (15 and 25°C) time (40 days) on growth/production trichothecene mycotoxin deoxynivalenol (DON) by Fusarium culmorum graminearum wheat grain. Methods Results: Studies examined colonization layers grain for 40 days. grew optimally at 0·98 aw minimally 0·90 15 25°C. Colonization F. was optimum 0·99 25 15°C. Overall, temperature, their interactions significantly affected growth both species. Production DON...
ABSTRACT Using data from whole-genome projects, an updated multiplex PCR strategy was developed to assign Escherichia coli isolates rapidly major phylogenetic groups. This assay accommodates sequence variations detected within target sequences, thereby increasing sensitivity and reliability. It validated using 185 of known types showed improved congruence with multilocus typing data.
Escherichia coli sequence types (STs) 69, 73, 95, and 131 are collectively responsible for a large proportion of E. urinary tract bloodstream infections, they differ markedly in their antibiotic susceptibilities. Here, we describe novel PCR method to rapidly detect distinguish these lineages. Three hundred eighteen published genomes were compared order identify signature sequences unique each the four major STs. The specificities assessed silico by seeking them an additional 98 genomes. A...
We determined the incidence, risk factors and antimicrobial susceptibility associated with Escherichia coli bacteraemia in England over a 24 month period. Case data were obtained from national mandatory surveillance database, linked LabBase2, voluntary microbiology database. Between April 2012 March 2014, 66,512 E. cases reported. Disease incidence increased by 6% 60.4 per 100,000 population 2012-13 to 63.5 2013-14 (p < 0.0001). Rates of varied patient age sex, 70.5% (46,883/66,512) seen...
SARS-CoV-2 is known to transmit in hospital settings, but the contribution of infections acquired hospitals epidemic at a national scale unknown.
Extraintestinal pathogenic
Investigation of the antibiotic susceptibilities and trends for staphylococci collected from bacteraemia cases in UK Ireland, 2001 to 2006, as part British Society Antimicrobial Chemotherapy's Bacteraemia Surveillance Programme.Twenty-five hospitals Ireland each up 10 consecutive isolates both Staphylococcus aureus coagulase-negative (CoNS) per year 2006. MIC determination identification species level were carried out centrally. mecA also mupA alleles sought by PCR S. CoNS 2005...
We analysed water sampled from the River Thames in London for Escherichia coli resistant to oxyimino-cephalosporins and/or fluoroquinolones, particularly seeking isolates with CTX-M extended-spectrum β-lactamases (ESBLs) and members of clinically important O25b:H4-ST131 lineage.River was collected three urban sites on by City Port Health Authority two occasions 1 week apart. Coliforms E. were identified Quanti-Tray™ method. Disc susceptibility tests performed MICs determined either...
Enterobacteriaceae are common agents of bacteraemia, with Escherichia coli accounting for 20% the cases. Reflecting this importance, members family constitute 4 12 collection groups in British Society Antimicrobial Chemotherapy (BSAC) Bacteraemia Surveillance Programme.MICs from BSAC surveillance programme were reviewed, along bacteraemia reports received by Health Protection Agency (HPA) via its CoSurv/LabBase system. Isolates unusual resistances subjected to molecular analysis.The and HPA...
ObjectivesBetween 1998 and 2000, 95.6% of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemias in the UK were due to two epidemic strains, namely EMRSA-15 or EMRSA-16 (60.2% 35.4%, respectively). We sought determine proportions these strains before after general decline MRSA bacteraemia that began around 2004.
ObjectivesThe UK saw major increases in cephalosporin and quinolone resistance amongst Enterobacteriaceae from 2001 to 2006, with largely reflecting dissemination of CTX-M extended-spectrum β-lactamases (ESBLs). We review subsequent trends.
ObjectivesWe characterized mechanisms of resistance to oxyimino-cephalosporins in Escherichia coli isolated from raw chicken meat imported into the UK South America, ascertain whether this foodstuff contributes dissemination extended-spectrum β-lactamase (ESBL)-producing E. belonging international uropathogenic ST131 clone.
The genetic surroundings of blaCTX-M-15 in Escherichia coli recovered from faeces travellers returning to the UK overseas were compared with those among established strains provide further insights into spread UK. From August 2006 January 2008, 1031 faecal specimens collected at North West London NHS Trust general practice patients a clinical history diarrhoea following recent international travel. Cefuroxime-resistant E. isolated on cystine-lactose-electrolyte deficient agar and that...