A5069060216- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Grief, Bereavement, and Mental Health
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Palliative Care and End-of-Life Issues
- Family Support in Illness
- SARS-CoV-2 detection and testing
- Urologic and reproductive health conditions
- Urinary and Genital Oncology Studies
- Migration, Health and Trauma
- Health Systems, Economic Evaluations, Quality of Life
- Endometrial and Cervical Cancer Treatments
- Sexual function and dysfunction studies
- Urinary Bladder and Prostate Research
- Childhood Cancer Survivors' Quality of Life
- Pelvic floor disorders treatments
- Cancer survivorship and care
- Tissue Engineering and Regenerative Medicine
- Nitric Oxide and Endothelin Effects
- BRCA gene mutations in cancer
- Effects of Radiation Exposure
- Genital Health and Disease
University of Cambridge
2017-2023
MRC Biostatistics Unit
2021-2023
Medical Research Council
2022
Karolinska Institutet
2011-2021
Vrije Universiteit Brussel
2017
Queen Mary University of London
2017
Fondazione Vincenzo Pansadoro
2017
University College London
2017
National Health Service
2017
Marie Cederschiöld University
2017
The omicron variant (B.1.1.529) of SARS-CoV-2 has demonstrated partial vaccine escape and high transmissibility, with early studies indicating lower severity infection than that the delta (B.1.617.2). We aimed to better characterise relative by assessing risk hospital attendance, admission, or death in a large national cohort.
The SARS-CoV-2 delta (B.1.617.2) variant was first detected in England March, 2021. It has since rapidly become the predominant lineage, owing to high transmissibility. is suspected that associated with more severe disease than previously dominant alpha (B.1.1.7) variant. We aimed characterise severity of compared by determining relative risk hospital attendance outcomes.
<b>Objective</b> To compare the survival outcomes of patients treated with surgery or radiotherapy for prostate cancer. <b>Design</b> Observational study. <b>Setting</b> Sweden, 1996-2010. <b>Participants</b> 34 515 men primarily cancer (n=21 533) (n=12 982). Patients were categorised by risk group (low, intermediate, high, and metastatic), age, Charlson comorbidity score. <b>Main outcome measures</b> Cumulative incidence mortality from other causes. Competing risks regression hazard ratios...
BRCA1 and BRCA2 mutations have been associated with prostate cancer (PCa) risk but a wide range of estimates reported that are based on retrospective studies. To estimate relative absolute PCa risks BRCA1/2 to assess modification by age, family history, mutation location. This was prospective cohort study male (n = 376) carriers 447) identified in clinical genetics centres the UK Ireland (median follow-up 5.9 5.3 yr, respectively). Standardised incidence/mortality ratios (SIRs/SMRs)...
Abstract Objective To evaluate the relation between diagnosis of covid-19 with SARS-CoV-2 variant B.1.1.7 (also known as concern 202012/01) and risk hospital admission compared wild-type variants. Design Retrospective cohort analysis. Setting Community based testing in England, individually linked data. Participants 839 278 patients laboratory confirmed covid-19, whom 36 233 had been admitted to within 14 days, tested 23 November 2020 31 January 2021 analysed at a an available TaqPath assay...
No AccessJournal of UrologyAdult Urology1 Dec 2014Robotic Intracorporeal Orthotopic Neobladder during Radical Cystectomy in 132 Patients Mihir M. Desai, Inderbir S. Gill, Andre Luis de Castro Abreu, Abolfazl Hosseini, Tommy Nyberg, Christofer Adding, Oscar Laurin, Justin Collins, Gus Miranda, Alvin C. Goh, Monish Aron, and Peter Wiklund DesaiMihir Desai Financial interest and/or other relationship with Hassen Medical Baxter. More articles by this author , GillInderbir Gill EDAP. AbreuAndre...
We surveyed the occurrence of physical symptoms among long-term gynaecological cancer survivors after pelvic radiation therapy, and compared with population-based control women.We identified a cohort 789 eligible treated therapy alone or combined surgery in Stockholm Gothenburg, Sweden. A group 478 women was randomly sampled from Swedish Population Registry. Data were collected through study-specific validated postal questionnaire 351 questions concerning gastrointestinal urinary tract...
To evaluate the effect of learning curve on operative, postoperative, and pathological outcomes first 67 totally intracorporeal robot-assisted radical cystectomies (RARCs) with neobladders performed by two lead surgeons at Karolinska University Hospital.Between December 2003 October 2012, patients (61 men six women) underwent RARC orthotopic urinary diversion main surgeons. Data were collected prospectively patient demographics, peri- postoperative including operation times, conversion...
HPV-DNA positive (HPVDNA+) oropharyngeal squamous cell carcinoma (OSCC) has better clinical outcome than negative (HPVDNA-) OSCC. Current treatment may be unnecessarily extensive for most HPV+ OSCC, but before de-escalation, additional markers are needed together with HPV status to predict response. Here the influence of HLA class I/HLA II expression was explored. Pre-treatment biopsies, from 439/484 OSCC patients diagnosed 2000-2009 and treated curatively, were analyzed I expression,...
No AccessJournal of UrologyAdult Urology1 Jan 2015Thromboembolic Complications in 3,544 Patients Undergoing Radical Prostatectomy with or without Lymph Node Dissection Stavros I. Tyritzis, Anna Wallerstedt, Gunnar Steineck, Tommy Nyberg, Jonas Hugosson, Anders Bjartell, Ulrica Wilderäng, Thordis Thorsteinsdottir, Stefan Carlsson, Johan Stranne, Eva Haglind, Nils Peter Wiklund, and LAPPRO Steering Committee† TyritzisStavros Tyritzis Section Urology, Department Molecular Medicine Surgery,...
Background: The Omicron variant (B.1.1.529) of SARS-CoV-2 has demonstrated partial vaccine escape and high transmissibility, with early studies indicating lower severity infection compared Delta (B.1.617.2). We sought to better characterise relative by assessing the risk hospital attendance, admission or death in a large national cohort.Methods: Individual-level data on laboratory-confirmed COVID-19 cases resident England between 22 November 2021 9 January 2022 were linked routine datasets...
Abstract The Omicron variant of SARS-CoV-2 became the globally dominant in early 2022. A sub-lineage (BA.2) was identified England January Here, we investigated hospitalisation and mortality risks COVID-19 cases with BA.2 ( n = 258,875) compared to BA.1 984,337) a large cohort study England. We estimated risk hospital attendance, admission or death using multivariable stratified proportional hazards regression models. After adjustment for confounders, had lower similar (HR 0.80, 95% CI...
ObjectivesTo determine how the intrinsic severity of successively dominant SARS-CoV-2 variants changed over course pandemic.MethodsA retrospective cohort analysis in NHS Greater Glasgow and Clyde (NHS GGC) Health Board. All sequenced non-nosocomial adult COVID-19 cases GGC with relevant lineages (B.1.177/Alpha, Alpha/Delta, AY.4.2 Delta/non-AY.4.2 Delta, non-AY.4.2 Delta/Omicron, BA.1 Omicron/BA.2 Omicron) during periods were included. Outcome measures hospital admission, ICU or death within...
Objective To evaluate the role of positive surgical margin (PSM) size/focality and location in relation to risk biochemical recurrence (BCR) after robot-assisted radical prostatectomy (RARP). Patients Methods Clinicopathological data were collected from 904 patients who underwent RARP at a single European institution 2002 2006. PSM status was defined as cancer cells inked margin, stratified by location. The outcome variable BCR, postoperative PSA level ≥0.2 ng/mL. We modelled...