A5081927739- Prostate Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Diabetes Treatment and Management
- Cancer survivorship and care
- Heart Failure Treatment and Management
- Childhood Cancer Survivors' Quality of Life
- Advanced Radiotherapy Techniques
- Cardiovascular Function and Risk Factors
- Management of metastatic bone disease
- Urologic and reproductive health conditions
- Optimism, Hope, and Well-being
- Urinary Bladder and Prostate Research
- Prostate Cancer Treatment and Research
- Endometrial and Cervical Cancer Treatments
- Family Support in Illness
- Head and Neck Cancer Studies
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Pancreatic function and diabetes
- Breast Cancer Treatment Studies
- Bladder and Urothelial Cancer Treatments
- Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Radiation Therapy and Dosimetry
- Patient-Provider Communication in Healthcare
AstraZeneca (Sweden)
2021-2024
AstraZeneca (Brazil)
2024
University of Gothenburg
2012-2023
Minneapolis VA Health Care System
2022
University of Minnesota
2022
Uppsala University
2020
Sahlgrenska University Hospital
2010-2016
St Savas Hospital
2013
Trakya University
2013
Karolinska Institutet
2011
Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure and cardiovascular death among patients with chronic a left ventricular ejection fraction 40% or less. Whether SGLT2 are effective in higher remains less certain.
Robot-assisted laparoscopic radical prostatectomy (RALP) has become widely used without high-grade evidence of superiority regarding long-term clinical outcomes compared with open retropubic (RRP), the gold standard.To compare patient-reported urinary incontinence and erectile dysfunction 12 mo after RALP or RRP.This was a prospective, controlled, nonrandomised trial patients undergoing in 14 centres using RRP. Clinical-record forms validated patient questionnaires at baseline surgery were...
Abstract Aims Sodium–glucose co‐transporter 2 (SGLT2) inhibitors, originally developed as glucose‐lowering agents, have been shown to reduce heart failure hospitalizations in patients with type diabetes without established failure, and diabetes. Their role preserved mildly reduced ejection fraction remains unknown. Methods Dapagliflozin Evaluation Improve the LIVEs of Patients With PReserved Ejection Fraction Heart Failure (DELIVER) is an international, multicentre, parallel group,...
This report describes the baseline clinical profiles and management of DELIVER (Dapagliflozin Evaluation to Improve Lives Patients With Preserved Ejection Fraction Heart Failure) trial participants how these compare with those in other contemporary heart failure preserved ejection fraction trials.The was designed evaluate effects sodium-glucose cotransporter-2 inhibitor dapagliflozin on cardiovascular death, (HF) hospitalization, or urgent HF visits patients mildly reduced left ventricular...
Frailty is increasing in prevalence. Because patients with frailty are often perceived to have a less favorable risk/benefit profile, they may be likely receive new pharmacologic treatments. We investigated the efficacy and tolerability of dapagliflozin according status heart failure mildly reduced or preserved ejection fraction randomized DELIVER (Dapagliflozin Evaluation Improve Lives Patients With Preserved Ejection Fraction Heart Failure).
Obesity is common and associated with unique phenotypic features in heart failure preserved ejection fraction (HFpEF). Therefore, understanding the efficacy safety of new therapies HFpEF patients obesity important. The effects dapagliflozin were examined according to body mass index (BMI) among Dapagliflozin Evaluation Improve LIVEs Patients With PReserved Ejection Fraction Heart Failure trial.Body was analysed by World Health Organization (WHO) categories as a continuous variable using...
Background: The prevalence of heart failure with mildly reduced or preserved ejection fraction markedly increases age, older individuals disproportionately facing excess risk for mortality and hospitalization. Methods: DELIVER trial (Dapagliflozin Evaluation to Improve the Lives Patients With Preserved Ejection Fraction Heart Failure) randomized patients New York Association functional class II–IV left ventricular >40% either dapagliflozin placebo a median follow-up period 2.3 years. We...
Patients recently hospitalized for heart failure (HF) are at high risk rehospitalization and death.The purpose of this study was to investigate clinical outcomes response dapagliflozin in patients with HF mildly reduced or preserved left ventricular ejection fraction (LVEF) who were enrolled during following hospitalization.The DELIVER (Dapagliflozin Evaluation Improve the LIVES With PReserved Ejection Fraction Heart Failure) trial randomized LVEF >40% placebo. permitted randomization...
Patients with heart failure mildly reduced ejection fraction (HFmrEF) and preserved (HFpEF) experience a high burden of symptoms, physical limitations, poor quality life; improving health status is key goal management.In prespecified analysis the DELIVER (Dapagliflozin Evaluation to Improve Lives With Preserved Ejection Fraction Heart Failure) trial, we examine effects dapagliflozin on using Kansas City Cardiomyopathy Questionnaire (KCCQ).The trial randomized patients symptomatic...
Sodium-glucose cotransporter 2 inhibitors reduce the risk of worsening heart failure (HF) and cardiovascular death in patients with HF irrespective left ventricular ejection fraction. It is important to determine whether therapies for improve symptoms functional capacity.
We surveyed the occurrence of physical symptoms among long-term gynaecological cancer survivors after pelvic radiation therapy, and compared with population-based control women.We identified a cohort 789 eligible treated therapy alone or combined surgery in Stockholm Gothenburg, Sweden. A group 478 women was randomly sampled from Swedish Population Registry. Data were collected through study-specific validated postal questionnaire 351 questions concerning gastrointestinal urinary tract...
The adoption of robot-assisted laparoscopic radical prostatectomy (RALP) has increased rapidly, despite lack conclusive evidence its superiority regarding long-term outcomes over open retropubic RP (RRP). In 2015, we reported on 12-mo follow-up from the LAPPRO trial showing a moderate advantage RALP erectile dysfunction. No significant differences were seen for urinary incontinence or surgical margin status.To present patient-reported functional and recurrent residual disease at 24-mo...
The rapid adoption of robot-assisted laparoscopy in radical prostatectomy has preceded data regarding associated costs. Qualitative evidence cost outcomes is lacking. This study assessed how costs were affected by laparoscopic (RALP) compared with open surgery. Cost analysis was based on the dataset LAPPRO (Laparoscopic Prostatectomy Robot Open) clinical trial, which a prospective controlled, nonrandomised trial patients who underwent at 14 centres Sweden between September 2008 and November...
No AccessJournal of UrologyAdult Urology1 Jan 2015Thromboembolic Complications in 3,544 Patients Undergoing Radical Prostatectomy with or without Lymph Node Dissection Stavros I. Tyritzis, Anna Wallerstedt, Gunnar Steineck, Tommy Nyberg, Jonas Hugosson, Anders Bjartell, Ulrica Wilderäng, Thordis Thorsteinsdottir, Stefan Carlsson, Johan Stranne, Eva Haglind, Nils Peter Wiklund, and LAPPRO Steering Committee† TyritzisStavros Tyritzis Section Urology, Department Molecular Medicine Surgery,...
To explore the early effects of dapagliflozin on myocardial function and metabolism in patients with type 2 diabetes without heart failure.Patients metformin treatment were randomized to double-blind, 6-week placebo or 10 mg daily treatment. Investigations included cardiac structure resonance imaging; oxygen consumption, perfusion efficiency [11 C]-acetate positron emission tomography (PET); hepatic fatty acid uptake [18 F]-6-thia-heptadecanoic PET, analysed by ANCOVA as least square means...
Atrial fibrillation (AF) is common in heart failure (HF), associated with worse outcomes compared sinus rhythm, and may modify the effects of therapy.This study examined dapagliflozin according to presence or not AF DELIVER (Dapagliflozin Evaluation Improve LIVEs Patients With PReserved Ejection Fraction Heart Failure) trial.A total 6,263 patients HF New York Association functional class II-IV, left ventricular ejection fraction >40%, evidence structural disease, elevated N-terminal...
Few data illustrate the man's reaction to orchidectomy. We investigated long-lasting feelings of loss and uneasiness or shame about body after removal a testicle by identified 1173 eligible men diagnosed with non-seminomatous testicular cancer treated according national cancer-care programmes Swedish-Norwegian Testicular Cancer Group I–IV between 1981 2004. asked survivors having had removed obtained information from 960 (82%) survivors. found that 32% these miss previously missed their...
Objective. This study describes the design and procedures for a prospective, non-randomized trial comparing open retropubic robot-assisted laparoscopic radical prostatectomy regarding functional oncological outcomes. Material methods. The aim was to achieve detailed prospective registration of symptoms experienced by patients using validated questionnaires in addition documentation surgical details, clinical examinations, medical facts resource use. Four patient six case-report forms were...
Purpose. The purpose of this study was to examine whether or not vaginal elasticity lack lubrication is associated with deep superficial dyspareunia. We investigated gynecological cancer survivors treated radiation therapy.Methods. In a population-based 616 women answering questionnaire (participation rate 78%) and who were radiotherapy for cancer, we analyzed information from 243 (39%) reported that they had intercourse during the previous six months. Analyses included log-binomial...