A5001070472- Heart Failure Treatment and Management
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Influenza Virus Research Studies
- Adenosine and Purinergic Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Viral Infections and Immunology Research
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Immune Cell Function and Interaction
- Potassium and Related Disorders
- Peptidase Inhibition and Analysis
- Cardiovascular Issues in Pregnancy
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Infective Endocarditis Diagnosis and Management
- Vagus Nerve Stimulation Research
- Cancer Treatment and Pharmacology
- Stuttering Research and Treatment
- Electrolyte and hormonal disorders
- Cardiac, Anesthesia and Surgical Outcomes
Brigham and Women's Hospital
2014-2025
Harvard University
2014-2025
University of Graz
2024
Medical University of Graz
2024
University of Freiburg
2014-2022
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2016-2022
University Medical Center Freiburg
2014-2022
Universidad de Navarra
2014
Baker Heart and Diabetes Institute
2014
Austrian Academy of Sciences
2014
Background: The prevalence of heart failure with mildly reduced or preserved ejection fraction markedly increases age, older individuals disproportionately facing excess risk for mortality and hospitalization. Methods: DELIVER trial (Dapagliflozin Evaluation to Improve the Lives Patients With Preserved Ejection Fraction Heart Failure) randomized patients New York Association functional class II–IV left ventricular >40% either dapagliflozin placebo a median follow-up period 2.3 years. We...
An expansion of fat mass is an integral feature patients with heart failure and preserved ejection fraction (HFpEF). While body index (BMI) the most common anthropometric measure, a measure central adiposity-the waist-to-height ratio (WHtR)-focuses on content distribution; not distorted by bone or muscle mass, sex, ethnicity; may be particularly relevant in HFpEF. The PARAGON-HF trial randomized 4796 ≥45% to valsartan sacubitril/valsartan. current work characterizes association BMI WHtR...
Objective— A solid body of evidence supports a role extracellular ATP and its P2 receptors in innate adaptive immunity. It promotes inflammation as danger signal various chronic inflammatory diseases. Thus, we hypothesize contribution receptor P2Y 2 vascular atherosclerosis. Approach Results— Extracellular induced leukocyte rolling, adhesion, migration vivo assessed by intravital microscopy sterile peritonitis. To test the atherosclerosis, or saline control was injected intraperitoneally 3×...
While beta-blockers are not recommended for the treatment of HFpEF according to latest ESC and AHA/ACC/HFSA guidelines, these therapies remain commonly used comorbidity management. There has been concern that might adversely influence clinical outcomes by limiting chronotropic response in HFpEF. To examine contemporary use implications patients with HFmrEF or In DELIVER trial, a total 6,263 symptomatic HF LVEF >40% were randomized dapagliflozin placebo across 20 countries. this prespecified...
Abstract Aims Patients with heart failure (HF) and history of myocardial infarction (MI) face a higher risk disease progression clinical events. Whether sodium–glucose cotransporter 2 inhibitors may modify trajectory in such individuals remains incompletely understood. Methods results The DAPA‐HF DELIVER trials compared dapagliflozin placebo patients symptomatic HF left ventricular ejection fraction (LVEF) ≤40% > 40%, respectively. In this pooled participant‐level analysis, we assessed...
Nucleotides such as ATP, ADP, UTP, and UDP serve proinflammatory danger signals via purinergic receptors on their release to the extracellular space by activated or dying cells. binds receptor Y6 (P2Y6) propagates vascular inflammation inducing expression of chemokines monocyte chemoattractant protein 1, interleukin-8, its mouse homologsCCL1 (chemokine [C-C motif] ligand 1)/keratinocyte chemokine, CXCL2 [C-X-C 2)/macrophage inflammatory 2, CXCL5 5)/LIX, adhesion molecules cell molecule 1...
Costimulatory cascades such as the CD40L-CD40 dyad enhance immune cell activation and inflammation during atherosclerosis. Here, we tested hypothesis that CD40 directly modulates traits of metabolic syndrome in diet-induced obesity mice.To induce syndrome, wild-type or CD40(-/-) mice consumed a high-fat diet for 20 weeks. Unexpectedly, exhibited increased weight gain, impaired insulin secretion, augmented accumulation inflammatory cells adipose tissue, enhanced proinflammatory gene...
Inflammation drives atherosclerosis and its complications. Anti-inflammatory therapy with interleukin 1 beta (IL-1β) antibody reduces cardiovascular events in patients elevated high-sensitive C-reactive protein (hsCRP). This study aims to identify the share of coronary heart disease (CHD) residual inflammation who may benefit from anti-inflammatory therapy. hsCRP low-density lipoprotein (LDL) levels were determined 2741 all-comers admitted cardiological ward our tertiary referral hospital...
High-dose trivalent compared with standard-dose quadrivalent influenza vaccine did not significantly reduce all-cause mortality or cardiopulmonary hospitalizations in patients high-risk cardiovascular disease the INVESTED trial. Whether humoral immune response to is associated clinical outcomes unknown.
Background: In patients with stable chronic heart failure a reduced ejection fraction (HFrEF), left ventricular (LVEF) provides limited prognostic value, especially in moderately to severely LVEF. Echocardiographic parameters of right function may be associated adverse clinical events these patients. Therefore, we analyzed 164 HFrEF prospective single-center cohort study evaluate whether the are worsening (WHF) hospitalizations, cardiovascular and all-cause deaths combined endpoints....
Abstract Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function pro-inflammatory M1 macrophages (M1) M2 (M2). present study found murine bone marrow-derived express unique profile during in vitro polarization. As assessed real-time polymerase chain reaction (PCR), Gαs-coupled P1 A2A and A2B are upregulated...
Worsening renal function may impact long-term outcomes in heart failure (HF). However, little is known about the longitudinal trajectories relation to HF hospitalization or how this high-risk clinical event impacts outcomes.In PARAGON-HF, we evaluated association between recency of prior (occurring pre-randomization) and subsequent first composite outcome: (i) time ≥50% decline estimated glomerular filtration rate (eGFR); (ii) development end-stage disease; (iii) death attributable causes. A...
BACKGROUND: COVID-19 has been associated with endothelial injury, resultant microvascular inflammation and thrombosis. Activated cells release express P-selectin von Willebrand factor, both of which are elevated in severe may be implicated the disease pathophysiology. We hypothesized that crizanlizumab, a humanized monoclonal antibody to P-selectin, would reduce morbidity death patients hospitalized for COVID-19. METHODS: An international, adaptive, randomized controlled platform trial,...
Importance Dapagliflozin has been shown to improve overall health status based on aggregate summary scores of the Kansas City Cardiomyopathy Questionnaire (KCCQ) in patients with heart failure (HF) mildly reduced or preserved ejection fraction enrolled Evaluation Improve Lives Patients With Preserved Ejection Fraction Heart Failure (DELIVER) trial. A comprehensive understanding responsiveness individual KCCQ items would allow clinicians better inform expected changes daily living treatment....
Extracellular adenosine-5'-triphosphate (ATP) acts as an import signaling molecule mediating inflammation via purinergic P2 receptors. ATP binds to the receptor P2X4 and promotes increased expression of pro-inflammatory cytokines. Because central role inflammation, we assumed a functional contribution ATP-P2X4-axis in atherosclerosis. Expression was atherosclerotic aortic arches from low-density lipoprotein receptor-deficient mice being fed high cholesterol diet assessed by real-time...
Importance Influenza-like illness (ILI) activity has been associated with increased risk of cardiopulmonary (CP) events during the influenza season. High-dose trivalent vaccine was not superior to standard-dose quadrivalent for reducing these in patients high-risk cardiovascular (CV) disease Influenza Vaccine Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure (INVESTED) trial. Objective To evaluate whether high-dose vaccination is benefit over CP periods high, local...
Introduction: A solid body of basic evidence support a role for extracellular ATP and its receptors as danger signals in various chronic inflammatory diseases including asthma, obstructive pulmonary disease (COPD), arthritis, allergic dermatitis, graft versus host other entities. The ATP- binding P2Y2- receptor is involved cell recruitment like COPD. Hypothesis: Atherosclerosis represents several lines suggest that the may contribute to atherogenesis. Methods: expression P2Y2 was determinded...