Fiona V Cresswell
A5070324473- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Bacterial Infections and Vaccines
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Research and Interventions
- Orthopedic Infections and Treatments
- Fungal Infections and Studies
- HIV, Drug Use, Sexual Risk
- Antifungal resistance and susceptibility
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Mycobacterium research and diagnosis
- Syphilis Diagnosis and Treatment
- Sex work and related issues
- Reproductive tract infections research
- Diagnosis and treatment of tuberculosis
- HIV-related health complications and treatments
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
- Kawasaki Disease and Coronary Complications
- Escherichia coli research studies
- Nail Diseases and Treatments
- Hepatitis C virus research
- Respiratory viral infections research
- Phytoplasmas and Hemiptera pathogens
Infectious Diseases Institute
2018-2025
Brighton and Sussex Medical School
2015-2025
Uganda Virus Research Institute
2019-2025
University of London
2018-2025
London School of Hygiene & Tropical Medicine
2017-2025
Makerere University
2017-2025
Infectious Diseases Research Collaboration
2025
University of Sussex
2014-2025
University Hospitals Sussex NHS Foundation Trust
2015-2024
Medical Research Council
2024
WHO recommends Xpert MTB/RIF as initial diagnostic testing for tuberculous meningitis. However, diagnosis remains difficult, with sensitivity of about 50-70% and culture 60%. We evaluated the performance new Ultra (Xpert Ultra)
IntroductionTuberculous meningitis accounts for 1–5% of tuberculosis cases. Diagnostic delay contributes to poor outcomes. We evaluated the performance new Xpert MTB/RIF Ultra (Xpert Ultra) tuberculous diagnosis.MethodsIn this prospective validation study, we tested cerebrospinal fluid (CSF) adults presenting with suspected (ie, headache or altered mental status clinical signs meningism) Mulago National Referral Hospital and Mbarara Regional in Uganda. centrifuged CSF, resuspended cell...
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis. The incidence and mortality TBM unknown due to diagnostic challenges limited disaggregated reporting treated by existing surveillance systems. We aimed estimate in adults (15+ years) globally. Using national data from Brazil, South Africa, United Kingdom, States America, Vietnam, we estimated fraction reported tuberculosis that TBM, case fatality ratios for each these countries. adjusted estimates according findings a...
Abstract Background High-dose rifampicin may improve outcomes of tuberculous meningitis (TBM). Little safety or pharmacokinetic (PK) data exist on high-dose in human immunodeficiency virus (HIV) coinfection, and no cerebrospinal fluid (CSF) PK from Africa. We hypothesized that would increase serum CSF concentrations without excess toxicity. Methods In this phase II open-label trial, Ugandan adults with suspected TBM were randomized to standard-of-care control (PO-10, 10 mg/kg/day),...
Hepatitis C virus (HCV) is increasingly common among human immunodeficiency (HIV)-infected men who have sex with men. We evaluated the efficacy of HCV core antigen in diagnosing acute an HIV-infected cohort. Compared polymerase chain reaction, proved sensitive (100%) and specific (97.9%). As a quick, simple, cost-effective test, it has considerable utility screening for HCV.
We present the updated British Association for Sexual Health and HIV guidelines post-exposure prophylaxis following sexual exposure (PEPSE). This document includes a review of current data to support use PEPSE, considers how calculate risks infection after potential exposure, provides recommendations on when PEPSE should not be considered. also which medications provide checklist initial assessment, make monitoring individuals receiving PEPSE. Special scenarios, cost-effectiveness issues...
BackgroundHIV-associated cryptococcal meningitis is the second leading cause of AIDS-related deaths, with a 10-week mortality rate 25–30%. Fungal load assessed by colony-forming unit (CFU) counts used as prognostic marker and to monitor response treatment in research studies. PCR-based assessment fungal could be quicker less labour-intensive. We sought design, optimise, validate quantitative PCR (qPCR) assays for detection, identification, quantification Cryptococcus infections patients...
Central nervous system (CNS) infections remain a major public health problem in Sub-Saharan Africa, causing 15%-25% of AIDS-related deaths. With widespread availability antiretroviral therapy (ART) and the introduction improved diagnostics, epidemiology infectious meningitis is evolving.We prospectively enrolled adults presenting with HIV-associated Kampala Mbarara, Uganda, from March 2015 to September 2017. Participants had structured, stepwise diagnostic algorithm performed blood...
We present the updated British Association for Sexual Health and HIV (BASHH) guidelines post-exposure prophylaxis (PEP) to following sexual exposures, occupational exposures other nonoccupational in community. This serves as an update 2015 BASHH guideline on PEP 2008 Expert Advisory Group AIDS PEP. aim provide evidence-based guidance best clinical practice provision, monitoring support of prevention acquisition sexual, The covers when prescribe PEP, what antiretroviral agents use how manage...
Individuals with cryptococcal antigenemia are at high risk of developing meningitis if untreated. The progression and timing from asymptomatic infection to is unclear. We describe a subpopulation individuals neurologic symptomatic but negative cerebral spinal fluid (CSF) studies. evaluated 1201 human immunodeficiency virus–seropositive hospitalized suspected in Kampala Mbarara, Uganda. Baseline characteristics clinical outcomes participants neurologic–symptomatic CSF antigen (CrAg) were...
Abstract The delayed diagnosis of tuberculous meningitis (TBM) leads to poor outcomes, yet the current diagnostic methods for identifying Mycobacterium tuberculosis in cerebrospinal fluid (CSF) are inadequate. first comparative study new GeneXpert MTB/RIF Ultra (Xpert Ultra) TBM suggested increased sensitivity Xpert Ultra. Two subsequent studies have shown has improved sensitivity, but insufficient negative predictive value exclude TBM. Collecting and processing large volumes CSF...
Untreated, miliary tuberculosis (TB) has a mortality approaching 100%. As it is uncommon there little specific data to guide its management. We report detailed from UK cohort of patients with and the associations predictive ability admission blood tests clinical outcomes.Routinely collected demographic, clinical, blood, imaging, histopathological microbiological were assessed for all TB identified London register 2008 2012 Northwest Hospitals NHS Trust. Multivariable logistic regression was...