A5075150271- Infectious Diseases and Tuberculosis
- Bacterial Infections and Vaccines
- Traumatic Brain Injury and Neurovascular Disturbances
- Tuberculosis Research and Epidemiology
- Orthopedic Infections and Treatments
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury Research
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Amoebic Infections and Treatments
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Single-cell and spatial transcriptomics
- Immune Response and Inflammation
- Infectious Encephalopathies and Encephalitis
- Antibiotics Pharmacokinetics and Efficacy
- Congenital Diaphragmatic Hernia Studies
- RNA Research and Splicing
- Head and Neck Surgical Oncology
- Neonatal Respiratory Health Research
- Epilepsy research and treatment
- Gene expression and cancer classification
- Sinusitis and nasal conditions
- Hemodynamic Monitoring and Therapy
University of Cape Town
2016-2025
Neuroscience Institute
2025
The Francis Crick Institute
2020-2023
Red Cross War Memorial Children's Hospital
2011-2023
Neurosciences Institute
2019
Wellcome Centre for Infectious Diseases Research in Africa
2016-2017
Wellcome Trust
2016
Creative Commons
2016
University of Eswatini
2016
Boston Children's Hospital
2013-2015
OBJECTIVES: To examine cerebrovascular pressure reactivity index (PRx) in a large cohort of children with severe traumatic brain injury (sTBI) association physiologic variables and outcome. DESIGN: Retrospective observational study. SETTING: Red Cross War Memorial Children’s Hospital Cape Town, South Africa. PATIENTS: Pediatric (≤ 14 yr old) sTBI patients intracranial (ICP) monitoring (postresuscitation Glasgow Coma Score [Glasgow Scale (GCS)] ≤ 8). MEASUREMENTS AND MAIN RESULTS: Data were...
Tuberculous meningitis (TBM) leads to death or disability in half the affected individuals. Tools assess severity and predict outcome are lacking. Neurospecific biomarkers could serve as markers of evolution brain injury, but have not been widely explored TBM. We examined neurological injury (neuromarkers) inflammation pediatric TBM their association with outcome.
Tuberculous meningitis (TBM) is the most severe form of TB with high rates mortality and morbidity. Here we conduct RNA-sequencing on whole blood as well ventricular lumbar cerebrospinal fluid (CSF) pediatric patients treated for TBM. Differential transcript expression TBM cases are compared healthy controls in non-TB cerebral infection CSF. Whole RNA-Seq analysis demonstrates a distinct immune response pattern TBM, significant increase both canonical non-canonical inflammasome activation...
Tuberculous meningitis (TBM) is a lethal and commonly occurring form of extra-pulmonary tuberculosis in children, often complicated by hydrocephalus which worsens outcome. Despite high mortality morbidity, little data on the impact neurodevelopment exists. We examined clinical characteristics, neurodevelopmental outcomes TBM hydrocephalus.Demographic (laboratory radiological findings) were prospectively collected children treated for probable definite with hydrocephalus. At 6 months, outcome...
Intracranial pressure (ICP) monitoring is a cornerstone of care for severe traumatic brain injury (TBI). Management ICP can help ensure adequate cerebral blood flow and oxygenation. However, studies indicate that hypoxia may occur despite normal the relationship between oxygenation poorly defined. This particularly important children in whom less known about intracranial dynamics.To examine partial tissue oxygen (PbtO2) with TBI (Glasgow Coma Scale score ≤ 8) admitted to Red Cross War...
Abstract The delayed diagnosis of tuberculous meningitis (TBM) leads to poor outcomes, yet the current diagnostic methods for identifying Mycobacterium tuberculosis in cerebrospinal fluid (CSF) are inadequate. first comparative study new GeneXpert MTB/RIF Ultra (Xpert Ultra) TBM suggested increased sensitivity Xpert Ultra. Two subsequent studies have shown has improved sensitivity, but insufficient negative predictive value exclude TBM. Collecting and processing large volumes CSF...
Background: Pediatric tuberculous meningitis (TBM) leads to high rates of mortality and morbidity. Prompt diagnosis initiation treatment are challenging; imaging findings play a key role in establishing the presumptive diagnosis. General brain well reported; however, specific data on cerebral vascular spinal involvement children sparse. Methods: This prospective cohort study examined admission followed up computed tomography scans magnetic resonance brain, vessels (magnetic angiogram) spine...
Paediatric traumatic brain injury (PTBI) is a major public health problem. However, recent epidemiological data for PTBI in South Africa (SA) are lacking.To establish demographic profile of severe admissions to the Red Cross War Memorial Children's Hospital (RCWMCH) over 5-year period, by investigating trends annual admissions, age, sex, language, time and day injury, aetiology. Methods. This retrospective, descriptive, quantitative study included children admitted RCWMCH with (TBI) between...
Metabolomic analysis of cerebrospinal fluid (CSF) is used to improve diagnostics and pathophysiological understanding neurological diseases. Alterations in CSF metabolite levels can partly be attributed changes brain metabolism, but relevant transport processes influencing concentrations should considered. The entry molecules including metabolites into the central nervous system (CNS), tightly controlled by blood-brain, blood-CSF, blood-spinal cord barriers, where aquaporins membrane-bound...
Limited knowledge is available on the pharmacokinetics of rifampicin in children with tuberculous meningitis (TBM) and its penetration into brain tissue, which site infection. In this analysis, we characterize distribution cerebrospinal fluid (CSF), lumbar (LCSF) ventricular (VCSF), extracellular (ECF).