A5064430185- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Long-Term Effects of COVID-19
- Atrial Fibrillation Management and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 and healthcare impacts
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood properties and coagulation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Acute Myeloid Leukemia Research
- Hemophilia Treatment and Research
- Blood transfusion and management
- Hemoglobinopathies and Related Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 epidemiological studies
- Systemic Lupus Erythematosus Research
- Intramuscular injections and effects
- Vitamin C and Antioxidants Research
- Blood donation and transfusion practices
- Chronic Lymphocytic Leukemia Research
- Diagnosis and Treatment of Venous Diseases
- Blood groups and transfusion
- SARS-CoV-2 and COVID-19 Research
Singapore General Hospital
2016-2025
Duke-NUS Medical School
2021-2024
SingHealth
2024
National University of Singapore
2023
Concord Repatriation General Hospital
2021-2023
The University of Sydney
2019-2021
National University Cancer Institute, Singapore
2020-2021
University Health System
2020-2021
National University Health System
2020-2021
Anzac Research Institute
2019-2021
Viral acute respiratory infections (ARI) are associated with thrombotic events,1 and the pathophysiology of this association is multifactorial.2 Although most ARIs mild, subpopulation patients can progress to severe disease excessive proinflammatory response, downstream uncontrolled cytokine storm being partially implicated for manifestation.3 As there extensive crosstalk between inflammation coagulation, it likely prothrombotic mechanisms in viral ARI could be further exacerbated suffering...
Abstract Sustained hypercoagulability and endotheliopathy are present in convalescent COVID‐19 patients for up to 4 months from recovery. The hemostatic, endothelial, inflammatory profiles of 39 recovered were evaluated 16 after recovery COVID‐19. These values compared with a control group healthy volunteers ( n = 124). (71.8% males, median age 43 years) reviewed at mean 12.7 ± 3.6 following One patient without cardiovascular risk factors had post acute ischaemic limb. Elevated D‐dimer...
Abstract Objective To determine the clinical outcomes of older COVID-19 patients who received DMB compared to those did not. We hypothesized that fewer administered would require oxygen therapy and/or intensive care support than Methodology Cohort observational study all consecutive hospitalized aged 50 and above in a tertiary academic hospital recent cohort Patients were oral vitamin D3 1000 IU OD, magnesium 150mg OD B12 500mcg (DMB) upon admission if they not therapy. Primary outcome was...
Abstract COVID-19 caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and other respiratory viral (non-CoV-2-RV) infections are associated with thrombotic complications. The differences in prothrombotic potential between SARS-CoV-2 non-CoV-2-RV have not been well characterised. We compared the rates these two groups of patients directly further delved into their coagulation profiles. In this single-center, retrospective cohort study, all consecutive admitted January 15th...
Introduction: Paroxysmal nocturnal haemoglobinuria (PNH) is a rare haematologic disease characterised by intravascular haemolysis, thrombophilia and bone marrow failure. There lack of established clinical guidance on the screening, diagnosis management PNH in Singapore. A relatively low level awareness among healthcare professionals regarding manifestations further contributes to diagnostic delays. Additionally, limited access complement inhibitors, like eculizumab, may delay treatment...
Rilzabrutinib is a covalent, reversible BTK inhibitor with multiple mechanisms targeting key immune thrombocytopenia (ITP) disease pathophysiology. The phase 3 LUNA3 study in previously treated adults persistent/chronic ITP evaluated oral rilzabrutinib 400 mg bid (n=133) vs placebo (n=69) for 24 weeks. At baseline overall, median age was 47 years (range, 18-80), 63% female, 7.7 year 0.3-52.2) duration of ITP, and 28% were splenectomized. Overall (N=202), 85 (64%) 22 (32%) patients achieved...
Abstract Thrombosis is one of the cardinal manifestations myeloproliferative neoplasms (MPN). The mechanisms leading to a prothrombotic state in MPN are complex and remain poorly understood. Platelet mitochondria play role platelet activation, but their number function have not been extensively explored date. We observed an increased platelets from patients compared with healthy donors. had proportion dysfunctional mitochondria. fraction depolarized at rest was essential thrombocythemia (ET)...
A hypercoagulable state is a predisposition for venous thromboembolism (VTE). The activated partial thromboplastin time (aPTT)-based clot waveform analysis (CWA) global haemostatic measure but its role in assessment of hypercoagulability and thrombotic disorders uncertain. We aimed to study the changes CWA parameters acute VTE. hypothesized that patients with VTE would demonstrate higher values than control without having elevated associated VTE.Clot data from (N = 45) objectively proven who...
Abstract Infections cause varying degrees of haemostatic dysfunction which can be detected by clot waveform analysis (CWA), a global marker. CWA has been shown to predict poor outcomes in severe infections with disseminated intravascular coagulopathy. The effect less bacterial and viral on not established. We hypothesized that different influence distinctively. Patients admitted infections, dengue upper respiratory tract were recruited if they had an activated partial thromboplastin time...
Abstract Background Arterial and venous thrombosis are reported to be common in critically ill COVID-19 patients. Method results This is a national multicenter retrospective observational study involving all consecutive adult patients who required intensive care units (ICU) admission between 23 January 2020 30 April Singapore. One hundred eleven were included the arterial thrombotic rates ICU 1.8% ( n = 2) 9.9% 11), respectively. Major bleeding rate was 14.8% 16). Conclusions Critically...
Thrombin generation assays and activated partial thromboplastin time (aPTT)-based clot waveform analysis (CWA), are some examples of global coagulation assays. Each modality evaluates different aspects the forming process to globally define haemostasis with exclusive measurement parameters. Data on CWA emerging, but its performance against other haemostatic is yet be ascertained. This study correlation between aPTT-based CAT parameters across a range INR in warfarin-treated patients.A...
Abstract Background The procoagulant profile of platelet concentrates (PCs) following transfusion has been difficult to evaluate due lack specific markers. This study aimed characterize platelets in PCs and the effect transfusion. Study design methods Buffy coat‐derived from 12 donors were pooled, split, then stored conventionally, cold (2–6°C) or cryopreserved (−80°C). Procoagulant profiles assessed by flow cytometry (GSAO + /P‐selectin ), lactadherin‐binding, calibrated automated...