A5002638169- Sleep and Wakefulness Research
- Scientific Computing and Data Management
- High-Energy Particle Collisions Research
- Complex Network Analysis Techniques
- Parallel Computing and Optimization Techniques
- Distributed and Parallel Computing Systems
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Sleep and related disorders
- RNA Research and Splicing
- Gas Dynamics and Kinetic Theory
- Chronic Lymphocytic Leukemia Research
- Complex Systems and Time Series Analysis
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Experimental and Theoretical Physics Studies
- scientometrics and bibliometrics research
- Advanced Thermodynamics and Statistical Mechanics
- Mitochondrial Function and Pathology
- Particle physics theoretical and experimental studies
- Cancer-related molecular mechanisms research
- Advanced Neuroimaging Techniques and Applications
- Bioinformatics and Genomic Networks
- Cold Atom Physics and Bose-Einstein Condensates
- Theoretical and Computational Physics
Petz Aladár Megyei Oktató Kórház
2019-2025
Babeș-Bolyai University
2014-2024
Cold Spring Harbor Laboratory
2011-2017
University College Dublin
2007-2008
University of Bergen
1997-2007
Goethe University Frankfurt
1999
Genome-wide studies have identified thousands of long noncoding RNAs (lncRNAs) lacking protein-coding capacity. However, most lncRNAs are expressed at a very low level, and in cases there is no genetic evidence to support their vivo function. Malat1 (metastasis associated lung adenocarcinoma transcript 1) among the abundant highly conserved lncRNAs, it exhibits an uncommon 3'-end processing mechanism. In addition, its specific nuclear localization, developmental regulation, dysregulation...
Huntington disease (HD) is a fatal autosomal dominant, neurodegenerative condition characterized by progressively worsening motor and nonmotor problems including cognitive neuropsychiatric disturbances, along with sleep abnormalities weight loss. However, it not known whether disturbances metabolic underlying the loss are present at premanifest stage.We performed comprehensive study in 38 gene carrier individuals 36 age- sex-matched controls. The consisted of 2 weeks actigraphy home, nights...
The pluripotent nature of embryonic stem cells (ESC) is associated with a dynamic open chromatin state and an irregular nuclear shape. It has been postulated that the absence Lamin A/C contributes to these features. However, we show mouse ESCs express low, yet readily detectable, amounts at both RNA protein levels. Full-length transcripts isoforms were detected by q-PCR deep sequencing. Additionally, expression was validated in multiple primary established ESC lines immunoblotting using...
Slow waves (SWs, 0.5–4 Hz) in field potentials during sleep reflect synchronized alternations between bursts of action and periods membrane hyperpolarization cortical neurons. SWs decline this is thought to be related a reduction synaptic strength networks central sleep's role maintaining brain function. A assumption current concepts function that sleep, associated recovery processes, are independent circadian rhythmicity. We tested hypothesis by quantifying all from 12 EEG derivations 34...
The MALAT1 (Metastasis-Associated Lung Adenocarcinoma Transcript 1) gene encodes a noncoding RNA that is processed into long nuclear retained transcript (MALAT1) and small cytoplasmic tRNA-like (mascRNA). Using an sequence- structure-based covariance model, we identified more than 130 genomic loci in vertebrate genomes containing the 3′ end triple-helix structure its immediate downstream structure, including 44 green lizard Anolis carolinensis. Structural computational analyses revealed...
It has previously been reported that EEG sigma (10–15 Hz) activity during sleep exhibits infraslow oscillations (ISO) with a period of 50 s. However, detailed analysis the ISO individually identified spindles is not available. We investigated basic properties baseline 34 healthy young human participants using new and established methods. The analyses focused on fast spindle (13–15 in NREM stage 2 slow wave (SWS). To describe we analyzed power signal. For study applied method which signal was...
We study the effects of strict conservation laws and problem negative contributions to final momentum distribution during freeze out through 3-dimensional hypersurfaces with space-like normal. some suggested solutions for this problem, demonstrate it on one example.
We investigated whether the benefit of slow wave sleep (SWS) for memory consolidation typically observed in healthy individuals is disrupted people with accelerated long-term forgetting (ALF) due to epilepsy. SWS thought play an active role declarative and, furthermore, electrographic epileptiform activity often more prevalent during than wakefulness or other stages. studied relationship between and retention using a word-pair associates task. In both ALF control groups, conferred benefit....
Rilzabrutinib is a covalent, reversible BTK inhibitor with multiple mechanisms targeting key immune thrombocytopenia (ITP) disease pathophysiology. The phase 3 LUNA3 study in previously treated adults persistent/chronic ITP evaluated oral rilzabrutinib 400 mg bid (n=133) vs placebo (n=69) for 24 weeks. At baseline overall, median age was 47 years (range, 18-80), 63% female, 7.7 year 0.3-52.2) duration of ITP, and 28% were splenectomized. Overall (N=202), 85 (64%) 22 (32%) patients achieved...
Accurate and efficient community detection in networks is a key challenge for complex network theory its applications. The problem analogous to cluster analysis data mining, field rich metric space-based methods. Common these methods geometric, distance-based definition of clusters or communities. Here we propose new geometric approach graph based on Voronoi diagrams. Our method serves as proof principle that the appropriate distance metrics graphs can bring set clustering science. We employ...
In fluid dynamical models the freeze-out of particles across a three-dimensional space-time hypersurface is discussed. The calculation final momentum distribution emitted described for surfaces, with both spacelike and timelike normals, taking into account conservation laws discontinuity.
The freeze-out (FO) problem is addressed for a covariant FO probability and finite layer with time-like normal vector continuing the line of studies introduced in Molnár et al (2006 Phys. Rev. C 74 024907). resulting post-FO momentum distribution functions are presented discussed. We show that general distributions non-thermal asymmetric even situations.
Abstract TP53 aberrations predict chemoresistance and represent a contraindication for the use of standard chemoimmunotherapy in chronic lymphocytic leukaemia (CLL). Recent next‐generation sequencing (NGS)‐based studies have identified frequent low‐burden mutations with variant allele frequencies below 10%, but clinical impact these is still matter debate. In this study, we aimed to scrutinise subclonal architecture using sensitive, NGS‐based mutation analysis ‘real‐world’ cohort 901...
The combination of network sciences, nonlinear dynamics and time series analysis provides novel insights analogies between the different approaches to complex systems. By combining considerations behind Lyapunov exponent dynamical systems average entropy transition probabilities for Markov chains, we introduce a measure characterizing on state-transition networks with special focus differentiating chaotic cyclic modes. One important property this consists its non-monotonous dependence...
Formal explanations of the dynamics free and heavy tops are considered to be known for centuries. However, intuitive understanding their unexpected behavior is still a challenge. In this paper, we present elementary force based several phenomena related symmetric tops, derived in inertial non-inertial reference frames. Simple calculations enabled by model equivalent spinning top, namely square-formed tube carrying streaming ideal fluid or frictionless chain. Precession combined,...