David Pestaña
A5012715770- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Long-Term Effects of COVID-19
- Airway Management and Intubation Techniques
- Cardiovascular Disease and Adiposity
- Neonatal Respiratory Health Research
- COVID-19 and healthcare impacts
- Renal function and acid-base balance
- Anesthesia and Neurotoxicity Research
- Family and Patient Care in Intensive Care Units
- SARS-CoV-2 and COVID-19 Research
- Nosocomial Infections in ICU
- Liver Disease Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Antibiotic Use and Resistance
- Antifungal resistance and susceptibility
- Cardiovascular Health and Disease Prevention
- Fungal Infections and Studies
Hospital Universitario Ramón y Cajal
2015-2025
Instituto Cajal
2021-2025
Universidad de Alcalá
2020-2024
Instituto Ramón y Cajal de Investigación Sanitaria
2014-2024
Hospital Universitario La Paz
2004-2020
Biogipuzkoa Health Research Institute
2020
Hospital Universitario Nuestra Señora de Candelaria
2014
Carmel Medical Center
2014
Hospital General Universitario de Ciudad Real
2014
Hospital Universitario Río Hortega
2014
There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes 2019 (Covid-19). Genomewide association analysis may allow for identification of potential genetic factors involved development Covid-19.
In this study, our objective was to determine whether a perioperative hemodynamic protocol based on noninvasive cardiac output monitoring decreases the incidence of postoperative complications and hospital length stay in major abdominal surgery patients requiring intensive care unit admission. Secondary objectives were time peristalsis recovery wound infection, anastomotic leaks, mortality.A randomized clinical trial conducted 6 tertiary hospitals. One hundred forty-two adult scheduled for...
ABSTRACT Background Respiratory failure is a key feature of severe Covid-19 and critical driver mortality, but for reasons poorly defined affects less than 10% SARS-CoV-2 infected patients. Methods We included 1,980 patients with respiratory at seven centers in the Italian Spanish epicenters pandemic Europe (Milan, Monza, Madrid, San Sebastian Barcelona) genome-wide association analysis. After quality control exclusion population outliers, 835 1,255 population-derived controls from Italy,...
Abstract Background With recent advances in technology, patients with acute respiratory distress syndrome (ARDS) and severe exacerbations of chronic obstructive pulmonary disease (ae-COPD) could benefit from extracorporeal CO 2 removal (ECCO R). However, current evidence these indications is limited. A European ECCO R Expert Round Table Meeting was convened to further explore the potential for this treatment approach. Methods modified Delphi-based method used collate experts’ views better...
Abstract Background Information is lacking regarding long-term survival and predictive factors for mortality in patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) undergoing invasive mechanical ventilation. We aimed estimate 180-day of COVID-19 requiring ventilation, develop a model mortality. Methods Retrospective, multicentre, national cohort study between March 8 April 30, 2020 16 intensive care units (ICU) Spain. Participants were consecutive...
Postoperative pulmonary and non-pulmonary complications are common problems that increase morbidity mortality in surgical patients, even though the incidence has decreased with increased use of protective lung ventilation strategies. Previous trials have focused on standard strategies intraoperative or postoperative period, but without personalizing these to suit needs each individual patient considering both periods as a global perioperative lung-protective approach. The trial presented...
Diagnosis of complicated candidaemia represents a challenge for clinicians since early clinical manifestations may be non-specific and difficult to identify, thus precluding an appropriate treatment.This was multicentre prospective study predicting episodes in patients with bloodstream infection caused by Candida species, while assessing the value follow-up blood cultures (BCs) persistence positive results T2Candida MR (T2MR) β-d-glucan (BDG) tests. Immediately after first BC yielding...
Abstract Background: Bacterial and fungal co-infection has been reported in patients with COVID-19, but there is limited experience on these infections critically ill patients.Aim: To assess the characteristics outcome of ICU-acquired COVID-19 patients.Methods: In this retrospective single-centre, case-control study, we included 140 severe admitted to ICU between March May 2020. We evaluated epidemiological, clinical microbiological features, infections.Results: Fifty seven (40.7%),...
Sedation is commonly required by critically ill patients and inadequate sedation may be hazardous. Traditionally, subjective scales have been used for monitoring sedation. Bispectral index has proposed, although its utility in the intensive care unit debated. Our aim was to evaluate depth of intubated surgical means two (Ramsay Observer's Assessment Alertness Sedation) bispectral index.Sedation assessed prospectively 50 postoperative requiring at least 24 h (35 propofol, 15...
Severe cases of Coronavirus Disease 2019 (COVID-19) can present with multiple neurological symptoms. The available neuropathological studies have described different lesions; the most frequent was presence neuroinflammation and vascular-related lesions. objective this study to report performed in a medical institution, abundant long intensive care unit stays, their associated clinical manifestations. This is retrospective monocentric case series based on reports 13 autopsies wide range...
Background: Early prediction of ICU death in acute hypoxemic respiratory failure (AHRF) could inform clinicians for targeting therapies to reduce harm and increase survival. We sought determine clinical modifiable non-modifiable features during the first 24 h AHRF associated with death. Methods: This is a development, testing, validation study using data from prospective, multicenter, nation-based, observational cohort 1241 patients (defined as PaO2/FiO2 ≤ 300 mmHg on mechanical ventilation...
The development of lung fibrosis is a major concern in patients recovered from severe COVID-19 pneumonia. This study aimed to document the evolution diffuse alveolar damage (DAD) fibrosing pattern and define transcriptional programs involved. Morphological, immunohistochemical analysis were performed samples obtained autopsy 33 (median illness duration: 36 days). Normal idiopathic pulmonary (IPF) used for comparison. Twenty-seven with DAD disease more than 2 weeks had fibrosis. Pathways...
The Surviving Sepsis Campaign was launched in 2002, aiming at a 25% reduction mortality sepsis during 5-year period. We hypothesized that the compliance with an adapted bundle would improve intensive care unit (ICU) survival cohort of surgical septic shock patients.A retrospective, observational study performed ICUs from two University hospitals. Seven quality indicators were considered to 182 patients: (1) administration antibiotics within 6 hours diagnosis shock, (2) initial effective...
The recent European Confederation of Medical Mycology (ECMM) and the International Society for Human Animal (ISHAM) 2020 consensus classification proposes criteria to define coronavirus 2019 (COVID-19)-associated invasive pulmonary aspergillosis (CAPA), including mycological evidence obtained via non-bronchoscopic lavage. Given low specificity radiological findings in patients with severe acute respiratory syndrome 2 (SARS-CoV-2) infection, this criterion makes it difficult differentiate...
Objectives To determine preoperative factors associated to myocardial injury after non-cardiac surgery (MINS) and develop a prediction model of MINS. Design Retrospective analysis. Setting Tertiary hospital in Spain. Participants Patients aged ≥45 years undergoing major with at least two measures troponin levels within the first 3 days postoperative period. All patients were screened for MANAGE trial. Primary secondary outcome We used multivariable logistic regression analysis study risk...
Abstract Background By controlling hypercapnia, respiratory acidosis, and associated consequences, extracorporeal CO 2 removal (ECCO R) has the potential to facilitate ultra-protective lung ventilation (UPLV) strategies decrease injury from mechanical ventilation. We convened a meeting of European intensivists nephrologists used modified Delphi process provide updated insights into role ECCO R in acute distress syndrome (ARDS) identify recommendations for future randomized controlled trial....