A5003161551- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Mast cells and histamine
- Vascular Tumors and Angiosarcomas
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Cardiac tumors and thrombi
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Head and Neck Cancer Studies
- Sarcoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- T-cell and Retrovirus Studies
- Cutaneous lymphoproliferative disorders research
- Ubiquitin and proteasome pathways
- Genetic factors in colorectal cancer
- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Ovarian cancer diagnosis and treatment
- Atrial Fibrillation Management and Outcomes
Centro de Investigación Biomédica en Red de Cáncer
2020-2025
Instituto Ramón y Cajal de Investigación Sanitaria
2011-2025
Instituto Cajal
2003-2025
Instituto de Salud Carlos III
2021-2025
Hospital Universitario Ramón y Cajal
2013-2024
Universidad de Alcalá
2001-2023
Centre for Biomedical Network Research on Rare Diseases
2022
Faculty (United Kingdom)
2021
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease whose prognosis associated with clinical features, cell-of-origin and genetic aberrations. Recent integrative, multi-omic analyses had led to identifying overlapping DLBCL subtypes. We used targeted massive sequencing analyze 84 diagnostic samples from multicenter cohort of patients treated rituximab-containing therapies median follow-up 6 years. The most frequently mutated genes were IGLL5 (43%), KMT2D (33.3%), CREBBP (28.6%),...
Abstract Peripheral T-cell lymphoma (PTCL) is a clinically aggressive disease, with poor response to therapy and low overall survival rate of approximately 30% after 5 years. We have analyzed series 105 cases diagnosis PTCL using customized NanoString platform (NanoString Technologies, Seattle, WA) that includes 208 genes associated differentiation, oncogenes tumor suppressor genes, deregulated pathways, stromal cell subpopulations. A comparative analysis the various histological types...
Secondary haemophagocytic lymphohistiocytosis (sHLH) is characterised by a hyper activation of immune system that leads to multiorgan failure. It suggested excessive response in patients with COVID-19 could mimic this syndrome. Some autopsy studies have revealed the presence haemophagocytosis images bone marrow, raising possibility, along HScore parameters, sHLH.Our objective ascertain existence sHLH some severe COVID-19.We report histological findings 16 COVID-19, focusing on obtained from...
Light-chain-restricted germinal centres are generally associated with the existence of a neoplastic lymphoproliferative disorder. The aim was to present series cases persistent lymph node enlargement that featured some showing light chain immunoglobulin restriction.A six reactive lymphadenitis and two Castleman's disease analysed by immunohistochemistry, IgH-polymerase reaction (PCR) microdissected PCR. In all contained population plasma cells plasmacytoid centre restriction. three monotypic...
Severe cases of Coronavirus Disease 2019 (COVID-19) can present with multiple neurological symptoms. The available neuropathological studies have described different lesions; the most frequent was presence neuroinflammation and vascular-related lesions. objective this study to report performed in a medical institution, abundant long intensive care unit stays, their associated clinical manifestations. This is retrospective monocentric case series based on reports 13 autopsies wide range...
Classic Hodgkin lymphoma (cHL) is characterized by a rich immune microenvironment as the main tumor component. It involves broad range of cell populations, which are largely unexplored, even though they known to be essential for growth and survival Reed-Sternberg cells. We profiled gene expression 25 FFPE cHL samples using NanoString technology resolved their compositions cell-deconvolution tools, thereby generating patient-specific signatures. The results confirm individual fingerprints...
The purpose of this study was to evaluate the suitability formalin-fixed and paraffin-embedded (FFPE) samples fixed fresh (FF) for single-cell RNA sequencing (scRNAseq). To end, we compared profiles from FFPE matched FF tissue one invasive carcinoma no special type (invasive ductal carcinoma-IDC) lobular (ILC) assess consistency in cell distribution molecular profiles. results were validated using immunohistochemistry (IHC), fluorescence situ hybridization (FISH), electron microscopy....
The development of lung fibrosis is a major concern in patients recovered from severe COVID-19 pneumonia. This study aimed to document the evolution diffuse alveolar damage (DAD) fibrosing pattern and define transcriptional programs involved. Morphological, immunohistochemical analysis were performed samples obtained autopsy 33 (median illness duration: 36 days). Normal idiopathic pulmonary (IPF) used for comparison. Twenty-seven with DAD disease more than 2 weeks had fibrosis. Pathways...
Santón A, García-Cosío M, Cristóbal E, Pascual Muriel A & García-Laraña J (2011) Histopathology58, 1072–1080 Expression of heat shock proteins in classical Hodgkin lymphoma: correlation with apoptotic pathways and prognostic significance Aims: Heat (HSPs), known to inhibit apoptosis promote cellular survival, are overexpressed many tumours. We analysed the expression relevant HSPs factor 1 (HSF1) lymphoma (cHL) their relationship caspase signalling patient outcome. Methods results: Using...
Blood eosinophil count (BEC) is currently used as a surrogate marker of T2 inflammation in severe asthma but its relationship with tissue T2-related changes elusive. Bronchial biopsy could add reliable information lacks standardization.To validate systematic assessment the bronchial for evaluation uncontrolled (SUA) by standardizing pathological score.A submucosal inflammation, eosinophilic count/field (TEC), goblet cells hyperplasia, epithelial changes, basement membrane thickening,...
Castleman disease (CD) represents a heterogeneous group of lymphoproliferative disorders that share well-defined histopathological features. An observational study patients with CD was conducted. A total 53 had CD: 20 the unicentric form (UCD) and 33 multicentric (MCD) variant; 10 latter cases were infected human herpesvirus-8 (HHV-8) 23 idiopathic (iMCD). Median age differed between UCD iMCD (30 vs. 49 years, p = .004). Males completely predominant in HHV-8-associated MCD (100%), females...
Abstract Background The significance of discrepant findings between histology (BMB) and flow cytometry (FC) in bone marrow (BM) examination at diffuse large B‐cell lymphoma (DLBCL) diagnosis is uncertain. Methods We performed a 5‐year retrospective single‐center study patients diagnosed by DLBCL not otherwise specified ( n = 82), divided into three groups according to BM infiltration diagnosis: BMB−/FC− (75.6%), BMB+/FC+ (13.4%), BMB−/FC+ (11%). Results Median FC analysis the group was 0.8%...
Lymphoplasmacytic lymphoma (LPL) and marginal zone (MZL) frequently infiltrate the bone marrow with similar histologic immunohistochemical characteristics posing diagnostic problems. Bone biopsy specimens from 25 LPL 16 MZL have been studied, correlating clinical, laboratory parameters MYD88_p.L265P mutation. Paratrabecular interstitial infiltration pattern, serum IgM paraprotein levels, mutation were significantly more frequent in LPL. Nodular or intrasinusoidal pattern lymphocytosis...