A5062868681- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Autoimmune Bullous Skin Diseases
- Vasculitis and related conditions
- Endometrial and Cervical Cancer Treatments
- Renal Diseases and Glomerulopathies
- Breast Lesions and Carcinomas
- Urologic and reproductive health conditions
- Lymphoma Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Cancer Diagnosis and Treatment
- Soft tissue tumor case studies
- CNS Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Genetic Neurodegenerative Diseases
- Hedgehog Signaling Pathway Studies
- Chronic Kidney Disease and Diabetes
- Oral health in cancer treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Mitochondrial Function and Pathology
- Renal Transplantation Outcomes and Treatments
- Chromatin Remodeling and Cancer
- Cardiac tumors and thrombi
- Reproductive tract infections research
Instituto Cajal
2021-2025
Instituto Ramón y Cajal de Investigación Sanitaria
2025
Hospital Universitario Ramón y Cajal
2018-2023
Universidad de Granada
1995
Background: Characterisation of molecular alterations pleomorphic lobular carcinoma (PLC), an aggressive subtype invasive (ILC), have not been yet completely accomplished. Methods: To investigate the with features, a total 39 tumour samples (in situ and lesions lymph node metastases) from 27 patients nuclear grade 3 carcinomas were subjected to morphological, immunohistochemical massive parallel sequencing analyses. Results: Our observations indicated that features morphologically...
Secondary haemophagocytic lymphohistiocytosis (sHLH) is characterised by a hyper activation of immune system that leads to multiorgan failure. It suggested excessive response in patients with COVID-19 could mimic this syndrome. Some autopsy studies have revealed the presence haemophagocytosis images bone marrow, raising possibility, along HScore parameters, sHLH.Our objective ascertain existence sHLH some severe COVID-19.We report histological findings 16 COVID-19, focusing on obtained from...
HER2 antibody-drug conjugates like Trastuzumab deruxtecan (TDxd) have shown efficacy in HER2-low cancers, however the prevalence and clinical impact of endometrial cancer (EC) remains unclear. This study investigates expression EC, focusing on frequency, its distribution across histologic molecular subtypes, intratumoral heterogeneity, prognostic significance. retrospective analysis included EC patients categorized histologically molecularly, using ASCO/CAP scoring guidelines for...
In this study, we developed a quantitative method with digital image analysis to evaluate the degree of gingival overgrowth (GO), and compared GO in kidney transplant patients treated cyclosporin A (CsA) (n = 21) or CsA+nifedipine 8) group healthy controls 30). The was reproducible reliable. Our findings showed significant differences papillary surface between inducers. Gingival index also differed significantly each patient (p < 0.01, Kruskal-Wallis test). administration calcium channel...
Abstract Background Immunohistochemistry (IHQ) is commonly used for the detection of mismatch repair proteins deficiency (MMRD). One very infrequent abnormal pattern MMR protein expression loss PMS2 and MSH6, with intact MLH1 MSH2. Case presentation We review frequency this MMRD IHC among 108 colorectal (CRCs) 35 endometrial cancers in our files at least one protein, present two CRCs showing MSH6 (1.9% CRCs). NGS analysis these tumours identified mutations (R134* germline mutation tumour M1R...
Abstract Background: Virilism is a female disorder in which secondary male sexual characteristics develop, caused by an excessive adrenal or ovarian androgen secretion. Case presentation: Here, we report unusual case of steroid cell tumor, not otherwise specified (NOS), 68-year-old who presented with androgenic alopecia, clitoromegaly and increased muscle mass. Laboratory investigations revealed both hyperandrogenism elevation precursors mimicking congenital hyperplasia. A left adnexal mass...
Secondary syphilis is a polymorphic condition resulting from the hematogenous and lymphatic dissemination of Treponema pallidum. Human immunodeficiency virus-positive patients are in greater risk atypical severe forms disease. The most common manifestation generalized papulosquamous eruption with variable mucosal involvement. However, annular plaques, split commissural papules, crusted necrotic or ulcerated lesions also frequent. Granulomatous lesions, both clinically histologically, less...
In this study, molecular alterations in endometrial carcinoma (EC) recurrences were analyzed. We aimed to identify genes implicated tumor progression and evaluate whether histologic type shifting occurs recurrences. Thus, we analyzed 50 samples corresponding 24 primary ECs (15 low-grade endometrioid carcinomas [LG-EECs] 9 high-grade carcinomas) their 26 These studied by immunohistochemistry, next-generation sequencing, MLH1 promoter methylation. observed shared mutations all tumors...
Proliferative fasciitis (PF) is a benign fibroblastic reaction with histological and clinical characteristics that overlap those of malignant soft tissue tumors; thus, it referred to as pseudosarcomatous reaction. It continues be an important cause diagnostic error overtreatment. The childhood PF subtype has some distinct immunohistochemical make differential diagnosis tumors even harder, especially sarcoma. These proliferations generally occur in the lower limbs, periorbital region rare...
Understanding the role of donor-specific antibodies (DSAs) in liver transplantation remains an investigative priority. Acute and chronic rejection associated with DSAs have been described. However, most transplant protocols did not consider presence at moment (LTx) or for follow-up. A 65-year-old man received ABO-compatible LTx cirrhosis. Ten years after LTx, he presented a progressive elevation enzymes bilirubin. The single antigen Luminex bead assay showed against several DQ2, DQ7, DQ8...
La ataxia de Friedreich es una enfermedad neurodegenerativa progresiva transmisión autosómica recesiva, que conforma la hereditaria más frecuente en nuestro medio. Se produce por expansión 33 repeticiones del triplete GAA, secundaria a mutación cromosoma 9q13. manifiesta antes los 25 años con síntomas neurológicos, locomotores, endocrinológicos y cardiológicos, siendo estos últimos marcan el pronóstico. esperanza vida 40-50 años. Existen medicamentos pretenden mejorar detener progresión...
Perineal carcinoma of unknown primary origin (CUP) is a rare entity and represents diagnostic therapeutic challenge. These tumors may respond well to combination surgical resection, when feasible, local radiotherapy, platinum-based systemic chemotherapy. A 67-year-old male patient consulted for urinary discomfort associated with perineal abscess. The abscess was drained, the diagnosed origin. Computed tomography (CT) scan shows large mass that involves both corpora cavernosa corpus...
Ampullary adenocarcinoma (AA) can originate from three different epitheliums, conditioning its evolution and prognosis. Recently, histomolecular classification has been defined, according to the presence of immunohistochemical (IHQ) markers intestinal (INT) lineage vs pancreatobiliary (PB). 42 AA patients were retrospectively reviewed morphologically molecular classified with IHQ MUC1, MUC2, CDX2, CK20 CK7 markers, system described by Chang et al. A prognostic study was carried out in...
Castleman’s disease is a rare lymphoproliferative disorder. The localized form the most frequent and it usually asymptomatic. Although definitive diagnosis histologic, necessary to know how manifests in imaging studies. location cases of unicentric thorax. We present case patient from our center improve interpretation proof this pathology.