A5050242057- Renal Diseases and Glomerulopathies
- COVID-19 Clinical Research Studies
- Drug-Induced Adverse Reactions
- Long-Term Effects of COVID-19
- Multiple Myeloma Research and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Complement system in diseases
- SARS-CoV-2 and COVID-19 Research
- Vasculitis and related conditions
- Renal Transplantation Outcomes and Treatments
- Food Allergy and Anaphylaxis Research
- Microtubule and mitosis dynamics
- Maternal Mental Health During Pregnancy and Postpartum
- Organ Transplantation Techniques and Outcomes
- Quinazolinone synthesis and applications
- Hematopoietic Stem Cell Transplantation
- Mast cells and histamine
- Protein Degradation and Inhibitors
- Immunodeficiency and Autoimmune Disorders
- Genomics and Chromatin Dynamics
- Skin Diseases and Diabetes
- COVID-19 Impact on Reproduction
- Platelet Disorders and Treatments
- Plant Disease Management Techniques
- vaccines and immunoinformatics approaches
Hospital Universitario Ramón y Cajal
2018-2024
Instituto Ramón y Cajal de Investigación Sanitaria
2020-2024
Universidad de Alcalá
2020-2024
MD Anderson Cancer Center Madrid
2023
ASST Fatebenefratelli Sacco
2023
Luigi Sacco Hospital
2023
University of Milan
2023
Instituto Cajal
2020-2022
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2021
Hospital Universitario Fundación Jiménez Díaz
2021
Immunosuppression (IS) and autoimmune disease (AD) are prevalent in patients with severe coronavirus 2019 (COVID-19), but their impact on its clinical course is unknown. We investigated relationships between IS, AD, outcomes hospitalized COVID-19. Data consecutive admissions for COVID-19 were extracted retrospectively from medical records. Patients assigned to one of four cohorts, according whether or not they had an AD (AD NAD) immunosuppressed (IS NIS). The primary endpoint was development...
Coronavirus disease 2019 (COVID-19) is a highly variable condition. Validated tools to assist in the early detection of patients at high risk mortality can help guide medical decisions.We sought validate externally, as well from second pandemic wave Europe, our previously developed prediction model for hospitalized COVID-19 patients.Three validation cohorts were generated: 2 external with 185 and 730 first 1 internal 119 wave. The probability death was calculated all subjects using model,...
Drug hypersensitivity reactions (DHR) to platinum-based compounds (PC) are on the rise, and their personalized safe management is essential enable first-line treatment of these cancer patients. This study aimed evaluate usefulness basophil activation test by flow cytometry (BAT-FC) newly developed sIgE-microarray BAT-microarray in diagnosing IgE-mediated PC. 24 patients with DHR PC (20 oxaliplatin four carboplatin) were evaluated: 13 diagnosed as allergic positive skin tests (STs) or drug...
Introducción: Se considera "Aglomeración" cuando un servicio de urgencias excede el número pacientes que tiene capacidad atender o no cuenta con las condiciones para cubrir necesidades del próximo paciente a ser atendido. Este estudio evalúa sobrecupo en hospital Colombia.Objetivo: Comparar la escala objetiva NEDOCS subjetiva personal salud departamento evaluar diferencia entre ambas.Métodos: aplicó y una al médico enfermera jefe turno durante 3 semanas seguidas, 6 veces día (6:00 a.m., 9:00...
Drug hypersensitivity reactions (DHRs) to platinum-based compounds (PCs) are on the rise, and their personalized safe management is essential enable first-line treatment for these cancer patients. This study aimed evaluate usefulness of basophil activation test by flow cytometry (BAT-FC) newly developed sIgE-microarray BAT-microarray in diagnosing IgE-mediated PCs. A total 24 patients with DHRs PCs (20 oxaliplatin four carboplatin) were evaluated: thirteen diagnosed as allergic positive skin...
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is the most common form of autoimmune encephalitis, caused by interaction between an antibody and its target, located on glutamate type N-methyl-D-aspartate neuronal surface. There a wide spectrum clinical features starting viral-like prodrome, followed symptoms such as psychosis, aggressive behaviour, memory loss, seizures, movement disorders, autonomic instability. Up to 50% affected young female patients have germ-cells tumours...
Rituximab (anti-CD20) is commonly used as immunotherapy against B cells, in the context of pre-transplant crossmatches, where presence rituximab tested sera with donor cells can alter their results both by flow cytometry (FCXM) complement-dependent cytotoxicity (CDCXM) giving rise to false positives. In present study, we use an anti-rituximab monoclonal antibody (10C5, Abnova) a method avoid positives FCXM and CDCXM. We serum from ten patients who received therapy rituximab, were incubated...
Background: Idiopathic inflammatory myopathies (IIM) are a group of immune-mediated diseases characterized my muscle weakness, skin rash and systemic involvement. Myositis-specific antibodies (MSA) myositis-associated (MAA) play major role in IIM diagnosis, classification prognosis. Nevertheless, MSA/MAA testing is not standardized there very few studies addressing their relationship with other diseases. Objectives: To describe cohort patients tested positive for MSA/MAA, to explore it´s...
Understanding the role of donor-specific antibodies (DSAs) in liver transplantation remains an investigative priority. Acute and chronic rejection associated with DSAs have been described. However, most transplant protocols did not consider presence at moment (LTx) or for follow-up. A 65-year-old man received ABO-compatible LTx cirrhosis. Ten years after LTx, he presented a progressive elevation enzymes bilirubin. The single antigen Luminex bead assay showed against several DQ2, DQ7, DQ8...
Candida albicans is part of the normal flora digestive tract, however in immunocompromised host can cause opportunisticinfection. According to Shaw's case series study North Carolina USA, colonization C. increased autism spectrumdisorders (ASD) patients. a dimorphism fungus, yeast phase grown at 37 °C and mould roomtemperature. The aim this was compare colony count stools ASD patients children, findcorrelation between state ASD. A cross sectional conducted from December 2004 March 2005on 50...
<h3>Background</h3> Immune checkpoint inhibitors (ICI), a type of immunotherapy which block negative co-stimulation T-cells, have surfaced as an important alternative treatment for advanced malignancies. Unfortunately, these agents been associated with immune-related adverse events (irAE). <h3>Objectives</h3> To analyse the frequency, and outcome irAE in Spanish patients treated ICI. <h3>Methods</h3> We carried out retrospective, observational longitudinal study, including adult diagnosed...
Abstract Background and Aims Patients with primary membranous nephropaty experience a spontaneous remission rate between 30-40%. AntiPLA2R antibodies are involved in the pathogenesis of disease. Some studies demonstrated that levels circulating anti-PLA2R beginning disease revealed strong correlation clinical activity, it could help discriminate against those who will make Method The principal objetive was to analize patients positive antiPLA2R antiboidies study serological variables...