A5051517744- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Organ Transplantation Techniques and Outcomes
- Systemic Lupus Erythematosus Research
- Chronic Kidney Disease and Diabetes
- Systemic Sclerosis and Related Diseases
- Multiple Sclerosis Research Studies
- Biomedical Research and Pathophysiology
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Autoimmune Bullous Skin Diseases
- Transplantation: Methods and Outcomes
- Complement system in diseases
- Urticaria and Related Conditions
- Genital Health and Disease
- Renal Transplantation Outcomes and Treatments
- Muscle and Compartmental Disorders
- Dialysis and Renal Disease Management
- Diabetes and associated disorders
- MicroRNA in disease regulation
- Blood Coagulation and Thrombosis Mechanisms
- Peripheral Neuropathies and Disorders
- Organ Donation and Transplantation
- Urologic and reproductive health conditions
Hospital General De Segovia
2013-2025
Hospital Universitario Ramón y Cajal
2015-2024
Instituto Ramón y Cajal de Investigación Sanitaria
2012-2022
Instituto Cajal
2018-2022
Hospital Universitario 12 De Octubre
2006-2022
Universidad de Alcalá
2022
Bellvitge University Hospital
2020
Hospital de Clínicas
2019
Center for Rheumatology
2017
Centro de Investigaciones Biológicas Margarita Salas
2017
Acute tubular necrosis (ATN) caused by ischemia/reperfusion (I/R) during renal transplantation delays allograft function. Identification of factors that mediate protection and/or epithelium recovery could help to improve graft outcome. We studied the expression, regulation and role hypoxia inducible factor 1-alpha (HIF-1 α), using in vitro vivo experimental models I/R as well human post-transplant biopsies. found HIF-1 α is stabilized proximal tubule cells ischemia unexpectedly late...
Ischemia/reperfusion (I/R) leads to Acute Kidney Injury. HIF-1α is a key factor during organ response I/R. We previously demonstrated that induced renal reperfusion, after ischemia. Here we investigate the role of and dependent mechanisms in repair By interference rat model I/R, observed loss expression mis-localization e-cadherin induction α-SMA, MMP-13, TGFβ, collagen I. Moreover, demonstrate inhibition promotes cell infiltrates by inducing IL-1β, TNF-α, MCP-1 VCAM-1, through NFkB...
Significance Statement Mutations in factor H–related protein 1 (FHR-1) that result duplication of its dimerization domain associate with the chronic renal disease C3 glomerulopathy (C3G), which is characterized by complement dysregulation. The molecular basis for this association only partially understood. authors show these FHR-1 mutations enhance FHR-1’s binding to C3-activated fragments on opsonized surfaces and promote an excessive activation overcomes FH regulation. They also elevated...
The exact role of viral replication in patients with severe COVID-19 has not been extensively studied, and it only possible to demonstrate the presence replicative virus for more than 3 months a few cases using different techniques. Our objective was study RNA SARS-CoV-2 autopsy samples who died from long after onset symptoms. Secondary superimposed pulmonary infections present these were also studied. We an series 27 disease duration, where extrapulmonary obtained. In addition...
Background: Interferon therapy at the injection sites has been related to different cutaneous lesions including erythema and induration as most frequent ones. While glycoprotein induces fatigue, fever is even believed precipitate autoimmune disorders such type I diabetes, thyroid disease systemic lupus erythematosus, a erythematosus‐like histologic reaction interferon site never reported. To our knowledge, microscopic self‐resolving lesion mimicking erythematosus of not described. Results:...
ABSTRACT Introduction Membranoproliferative glomerulonephritis (MPGN) represents a histologic pattern of glomerular injury that may be due to several aetiologies. Few studies have comprehensively analysed the recurrence MPGN according current classification system. Methods We collected multicentre, retrospective cohort 220 kidney graft recipients with biopsy-proven native disease between 1981 and 2021 in 11 hospitals. Demographic, clinical parameters prognostic interest were collected. The...
Summary Both human leucocyte antigen (HLA)‐G and indoleamine 2,3 dioxygenase (IDO) are key molecules involved in immune tolerance. HLA‐G is a non‐classical HLA class I molecule that can be expressed both membrane‐bound (HLA‐G1) soluble (HLA‐G5) forms, of which exhibit tolerogenic properties via interaction with inhibitory receptors present on natural killer (NK) cells, T cells antigen‐presenting (APC). IDO an enzyme acts by depleting the surrounding microenvironment essential amino acid,...
Adenomyoepithelioma of the breast is a rare neoplasm. We present case benign adenomyoepithelioma in an asymptomatic 60-year-old woman. This report illustrates mammogram, ultrasound, and magnetic resonance appearances this unusual lesion, with histopathological correlation.
The existence of antibodies to aquaporin-4 (AQP-4-ab) has identified neuromyelitis optica (NMO) and multiple sclerosis (MS) as different diseases. Although HLA-DRB1 alleles contribute MS risk, recent studies suggest that HLA back-ground differs between patients with NMO or in non-Caucasians populations. Our study was aimed analyze distribution Caucasians patients.We recruited a cohort 22 (73% were AQP-4-ab positive), 228 225 healthy controls from Spain we genotyped the locus. Then, performed...
We describe a pilomatricomal horn on the right arm of 39-year-old man. Although initially tumor was clinically thought to be verruca vulgaris, microscopic features were similar those found in classic pilomatricoma, except for epidermal location and presence cutaneous horn. Light microscopy showed replacement epidermis by basaloid cells, with masses cornified material containing shadow cells that formed Whereas pilomatricoma is confined deep reticular dermis or subcutis, present case...
Background: Seronegative celiac disease (CD) poses a diagnostic challenge.Aims: Characterize and identify differences between seronegative seropositive CD.Patients methods: Retrospective cohort study examining adult patients diagnosed with CD (1980–2017). Clinical, analytical, histological, genetic immunophenotypic data were compiled. was defined as anti-tissue transglutaminase type 2 IgA endomysial antibodies (EMA) negative HLA-DQ2 and/or DQ8 positive, showing clinical signs of plus an...
AbstractWe describe the case of a 58-year-old woman with autoimmune enteropathy associated thyroiditis, gastritis, transitory neutropenia, sicca syndrome and severe axonal polyneuropathy origin. Enterocyte autoantibodies were not detected. However, predisposition to disease was indicated by presence high titres anti-gastric parietal cell, anti-thyroglobulin, anti-thyroid peroxidase anti-neutrophil antibodies. CD4+ CD8+ lymphocytes equally distributed in lamina propria small intestine, but...