A5045854773- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Bone health and osteoporosis research
- Vasculitis and related conditions
- COVID-19 Clinical Research Studies
- Parathyroid Disorders and Treatments
- Bone and Joint Diseases
- Long-Term Effects of COVID-19
- Aging, Health, and Disability
- Immunodeficiency and Autoimmune Disorders
- Dialysis and Renal Disease Management
- Vitamin D Research Studies
- Liver Disease and Transplantation
- Spondyloarthritis Studies and Treatments
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Neurological Complications and Syndromes
- T-cell and B-cell Immunology
- Pharmacological Effects and Toxicity Studies
Marqués de Valdecilla University Hospital
2015-2025
Servicio Cántabro de Salud
2016-2025
Instituto de Investigación Marqués de Valdecilla
2015-2025
Universidad de Cantabria
2015-2025
Biogipuzkoa Health Research Institute
2022
Fundação CECIERJ
2016
Pediatric Nephrology of Alabama
2003-2015
Mayo Clinic
2012-2014
Fundación Marques de Valdecilla
2012-2013
Mayo Clinic in Arizona
2012
The use of donation after circulatory death (DCD) has increased significantly during the past decade. However, warm ischemia results in a greater risk for transplantation. Indeed, controlled DCD (cDCD) was associated with inferior outcomes compared brain death. abdominal normothermic regional perfusion (nRP) to restore blood flow before organ recovery cDCD been proposed as better than rapid reverse effect and improve recipients' outcome. Here, first Spanish series using nRP an situ...
Lack of adherence to immunosuppressive drugs is a risk factor for development de novo donor-specific antibodies (dnDSA) and can contribute antibody-mediated rejection graft loss. Moreover, nonadherence the main determinant drug level variability. High intrapatient variability tacrolimus relates worse outcome in transplant recipients through unknown mechanisms. We hypothesized that high within-patient could increase rate dnDSA further death-censored loss (DCGL).We included 310 adult renal...
Post-COVID syndrome (PCS) is a poorly known entity. An underlying chronic, low-grade inflammation (LGI) has been theorized as pathophysiological mechanism. Available data on biomarkers in PCS show conflicting results. Our aim was to know whether subjects with present higher levels of inflammatory markers, after mild COVID-19.Analytical cross-sectional study. Cases COVID-19 community setting were included. We collected epidemiological (age, sex, BMI, smoking, comorbidities), variables the...
Kidney allografts are frequently lost due to alloimmunity. Still, the impact of early acute rejection (AR) on long-term graft survival is debated. We examined this relationship focusing histology post-AR and assessing specific causes loss. Included 797 recipients without anti-donor antibodies (DSA) at transplant who had 1 year protocol biopsies. 15.2% AR diagnosed by or clinical Compared no-AR, all histologic types led abnormal in 2 years biopsies, including more fibrosis + inflammation...
Abstract Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant bacteria (MDR). In this study, the biofilm-forming capability 209 MDR strains ( Escherichia coli n = 106, Klebsiella pneumoniae 78, and Enterobacter spp. 25) isolated from rectal swabs in first 48 hours before or after kidney (93 patients), liver (60 patients) kidney/pancreas transplants (5 were evaluated using a microplate assay. Thirty-nine 170 post-transplant. Overall,...
The aims of this study were to compare in participants with and without metabolic syndrome (1) bone mineral density (BMD), (2) prevalent vertebral nonvertebral fractures, (3) calciotropic hormones turnover markers examine the association each component parameters.A cross-sectional (495 men 1,013 women) from Camargo Cohort Study was conducted. A multivariable regression approach used analyze relationship between components parameters.Women had higher age-adjusted BMD at all localizations (P <...
Secretory phospholipase A2 receptor (PLA2R) is the target antigen of auto-antibodies produced in most (∼ 70%) patients with primary membranous nephropathy (pMN). The applicability anti-PLA2R1 antibody monitoring for prediction MN recurrence kidney transplant recipients still a matter debate.We sought to characterize presence and concentration anti-PLA2R antibodies by enzyme-linked immunosorbent assay (ELISA) cohort 21 pMN before after transplantation evaluate whether concentrations could...
Antiviral prophylaxis is recommended in cytomegalovirus (CMV)-seropositive kidney transplant (KT) recipients receiving antithymocyte globulin (ATG) as induction. An alternative strategy of premature discontinuation after CMV-specific cell-mediated immunity (CMV-CMI) recovery (immunoguided prevention) has not been studied. Our aim was to determine whether it effective and safe discontinue when CMV-CMI detected continue with preemptive therapy.In this open-label, noninferiority clinical trial,...
Proteinuria in the general population has been shown to be associated with cardiovascular disease, which is main cause of death renal transplantation. We investigated effect proteinuria on disease after transplantation 532 transplant patients functioning grafts for more than 1 year. Patients were classified into two groups depending presence persistent proteinuria. analyzed graft and patient survival, posttransplantation causes loss death. Five- 10-year survival rates lower group The was...
Although the diagnosis of membranous glomerulonephritis (MGN) may be suspected on routine histology formalin-fixed paraffin-embedded tissue, fresh-frozen tissue must used to show immunologic nature process by direct immunofluorescence (IF). The efficiency IF or immunoperoxidase (IP) detection IgG and C3 using paraffin sections is controversial. This study was designed evaluate whether glomerular C4d deposition an IP method in a useful marker for MGN. We showed characteristic glomerular,...
ABSTRACT Introduction Membranoproliferative glomerulonephritis (MPGN) represents a histologic pattern of glomerular injury that may be due to several aetiologies. Few studies have comprehensively analysed the recurrence MPGN according current classification system. Methods We collected multicentre, retrospective cohort 220 kidney graft recipients with biopsy-proven native disease between 1981 and 2021 in 11 hospitals. Demographic, clinical parameters prognostic interest were collected. The...
Our aim was to analyze the performance of two scores developed for predicting diabetes in nontransplant populations identifying kidney transplant recipients with a higher new-onset mellitus after transplantation (NODAT) risk beyond first year transplantation.We analyzed 191 transplants, which had at least 1-year follow-up posttransplant. First-year posttransplant variables were collected estimate San Antonio Diabetes Prediction Model (SADPM) and Framingham Offspring Study-Diabetes Mellitus...
Epidemiological studies of acute kidney injury (AKI) have focused on patients admitted to intensive care units (ICUs), and several studied hospitalized non-ICU patients, but analysis referred Nephrology is sparse. We analyzed factors associated with short- long-term morbimortality among AKI who were Nephrology.A retrospective study data prospectively collected from 170 referral the Unit, recruited over a 4-year period, was performed. classified according criteria based risk, injury, failure,...
Kidney disease is a common complication in heart transplant recipients and requires comprehensive personalized approach. The interplay between preexisting kidney disease, perioperative factors, immunosuppression, cardiovascular complications makes the management of dysfunction challenging these patients. objective this expert consensus was to look for agreements chronic recipients. A panel Spanish cardiologists nephrologists with expertise transplantation reviewed evidence related current...
Introduction While the impact of COVID-19 on bone metabolism has been extensively studied, inverse relationship remains less understood. This study investigates whether impaired is associated with an increased risk infection.
Background. The aim of our study is to share experience with uncontrolled donation after the circulatory determination death (uDCDD) kidney transplantation and propose updated donor selection criteria for uDCDD programs. Methods. A prospective comparing recipients grafts from local donors standard neurological (DNDD) between 2013 2024. Donor acceptance was determined using a combination 3 factors: age, no-flow period, warm ischemic time (WIT). Normothermic regional perfusion preservation...
Pretransplant cardiac troponin T(cTnT(pre) ) is a significant predictor of survival postkidney transplantation. We assessed correlates cTnT levels pre- and posttransplantation their relationship with recipient survival. A total 1206 adult recipients kidney grafts between 2000 2010 were included. was elevated (≥0.01 ng/mL) in 56.4%. Higher cTnT(pre) associated increased risk posttransplant death/cardiac events independent cardiovascular factors. Elevated declined rapidly normal 75% at 3 weeks...