A5060474842- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Genomic variations and chromosomal abnormalities
- Immunotherapy and Immune Responses
- Genetic and phenotypic traits in livestock
- Forensic and Genetic Research
- Genetic diversity and population structure
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Cultural and Sociopolitical Studies
- Parvovirus B19 Infection Studies
- Mosquito-borne diseases and control
- PARP inhibition in cancer therapy
- Cardiovascular Disease and Adiposity
- Global Energy Security and Policy
- Genetics and Neurodevelopmental Disorders
- Chromosomal and Genetic Variations
- Evolution and Genetic Dynamics
- Autism Spectrum Disorder Research
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Microbial infections and disease research
- Single-cell and spatial transcriptomics
- Diverse Cultural and Social Studies
Kiel University
2024-2025
Max Planck Institute for Evolutionary Biology
2020-2023
Universität Hamburg
2021-2023
Middle East Technical University
2020-2021
Biogipuzkoa Health Research Institute
2020
Izmir Tepecik Eğitim ve Araştırma Hastanesi
2013
Cukurova University
2011
Abstract Sheep were among the first domesticated animals, but their demographic history is little understood. Here we analyzed nuclear polymorphism and mitochondrial data (mtDNA) from ancient central west Anatolian sheep dating Epipaleolithic to late Neolithic, comparatively with modern-day breeds Asian Neolithic/Bronze Age (OBI). Analyzing data, found that Neolithic (ANS) are genetically closest present-day European relative breeds, a conclusion supported by mtDNA haplogroup frequencies. In...
Abstract Background The northern European Neolithic is characterized by two major demographic events: immigration of early farmers from Anatolia at 7500 years before present, and their admixture with local western hunter-gatherers forming late farmers, around 6200 present. influence this event on variation in the immune-relevant human leukocyte antigen (HLA) region understudied. Results We analyzed genome-wide data 125 individuals seven archeological farmer sites located present-day Germany....
A key component of pathogen-specific adaptive immunity in vertebrates is the presentation pathogen-derived antigenic peptides by major histocompatibility complex (MHC) molecules. The excessive polymorphism observed at MHC genes widely presumed to result from need recognize diverse pathogens, a process called pathogen-driven balancing selection. This assumes that pathogens differ their peptidomes-the pool short derived pathogen's proteome-so different select for variants with distinct...
ABSTRACT The northern European Neolithic is characterized by two major demographic events: immigration of early farmers (EF) from Anatolia (5500 BCE) and their admixture (from ∼4200 with western hunter-gatherers (WHG) forming late (LF). influence this event on variation in the immune-relevant human leukocyte antigen (HLA) region understudied. Here, we conducted population immunogenetic analyses 83 individuals six EF LF sites located present-day Germany. We observed significant shifts HLA...
ABSTRACT Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis host genetic contribution to severe COVID-19 is important improve our understanding underlying mechanisms. Here, we describe an extended GWAS meta-analysis well-characterized cohort 3,260 patients with respiratory failure and 12,483 population controls from Italy, Spain, Norway Germany/Austria, including stratified analyses based on age, sex severity, as well targeted chromosome Y...
Abstract The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data for understanding their adaptation to pathogens. Here, we describe the TARGT pipeline targeted loci from low-coverage shotgun sequence data. was successfully applied medieval aDNA samples validated both simulated modern empirical 1000 Genomes Project. Thus enables accurate...
Aim: The purpose of this article was to evaluate the reliability maternal serum triple marker screening alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol for prenatal diagnosis fetal chromosomal abnormalities in Turkish pregnant women. Method: Medical records were used analyze indications amniocentesis quantitative fluorescent-polymerase chain reaction. Anomaly performed all patients between 13 22 weeks pregnancy. A total 1725 pregnancies with abnormality risk...
Abstract Sheep was among the first domesticated animals, but its demographic history is little understood. Here we present combined analyses of mitochondrial and nuclear polymorphism data from ancient central west Anatolian sheep dating to Late Glacial early Holocene. We observe loss haplotype diversity around 7500 BCE during Neolithic, consistent with a domestication-related bottleneck. Post-7000 BCE, haplogroup increases, compatible admixture other domestication centres and/or wild...
Abstract Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae ( M. ) that reached an epidemic scale in the Middle Ages. Nowadays, absent Europe and host genetic influences have been considered as contributing factor to leprosy disappearance. In this study, case-control association analysis between multiple human leukocyte antigen (HLA) alleles was performed medieval European population for first time. The sample comprised 293 individuals from 18 archaeological...
“Doğa bir savaş alanıdır.” sözünü, çayırlarda koşturan aslan ve geyiklerden çok, bağışıklık sisteminde yaşananlar olarak anlamak mümkündür. Moleküler düzeydeki evrimsel savaşın en serti patojenler (yani hastalık yapan organizmalar) ile konak canlıların sistemi arasında gerçekleşmektedir desek abartmış olmayız. Birlikte evrimin güzel örneklerini görebileceğimiz bu çekişme, aslında temel organizmanın “ben diğerleri” ayrımını yapabilmesine dayanmaktadır. Patojenler için