A5090777636- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Angiogenesis and VEGF in Cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Peroxisome Proliferator-Activated Receptors
- Multiple Sclerosis Research Studies
- Autoimmune Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- S100 Proteins and Annexins
- Immune cells in cancer
- Pregnancy and Medication Impact
- Herpesvirus Infections and Treatments
- Infectious Encephalopathies and Encephalitis
- Ubiquitin and proteasome pathways
- Hemoglobinopathies and Related Disorders
- Nitric Oxide and Endothelin Effects
- Renal Diseases and Glomerulopathies
- Diet and metabolism studies
- Eicosanoids and Hypertension Pharmacology
- Traumatic Brain Injury and Neurovascular Disturbances
University Hospital Münster
2016-2025
Osnabrück University
2024
University of Münster
2022-2024
VIB-KU Leuven Center for Cancer Biology
2017-2018
KU Leuven
2017-2018
University of Rostock
2013-2014
Abstract Background Assessment of quality life (QoL) has become an important indicator for chronic neurological diseases. While these conditions often limit personal independence and autonomy, they are also associated with treatment-related problems reduced expectancy. Epilepsy a tremendous impact on the QoL patients their families, which is underestimated by practitioners. The aim this work was to identify relevant factors affecting in adults epilepsy. Methods This cross-sectional,...
Abstract Epilepsy is one of the most common neurological disorders in world. Common epileptic drugs generally affect ion channels or neurotransmitters and prevent emergence seizures. However, up to a third patients suffer from drug-resistant epilepsy, there an urgent need develop new therapeutic strategies that go beyond acute antiepileptic (antiseizure) therapies towards therapeutics also might have effects on chronic epilepsy comorbidities such as cognitive decline depression. The...
Seizure clusters, prolonged seizures, and status epilepticus are life-threatening neurological emergencies leading to irreversible neuronal damage. Benzodiazepines current evidence-based rescue therapy options; however, recent investigations indicated the prescription of mainly unsuitable benzodiazepines inappropriate use medication.
Hyperexcitability is associated with neuronal dysfunction, cellular death, and consequently neurodegeneration. Redox disbalance can contribute to hyperexcitation increased reactive oxygen species (ROS) levels are observed in various neurological diseases. NOX4 an NADPH oxidase known produce ROS might have a regulating function during oxidative stress. We, therefore, aimed determine the role of on firing, hyperexcitability, hyperexcitability-induced changes neural network function. Using...
Toll-like receptor 2 (TLR2) inhibition by function blocking antibodies (ABs) is associated with enhanced preservation of endothelial cell during vascular disease. In the present study, we investigated capacity TLR2-blocking ABs to modulate angiogenic response cells in vitro and vivo.Incubation mono- or polyclonal anti-TLR2 resulted increased tube formation, sprouting, migration compared controls. a mouse model hindlimb ischemia, using TLR2-deficient AB-treated wild-type mice new capillary...
Procalcitonin is used as a diagnostic tool for the identification and risk stratification of septic patients. plasma concentrations tightly correlate with severity ongoing inflammatory reaction can rise up to 10,000-fold. Impairment endothelial cell function plays an important role in pathogenesis hypotension disturbed organ perfusion during sepsis. We investigated possible effects procalcitonin itself on viability.Human cells were exposed 0.01 100 ng/mL permeability using transwells,...
Abstract Background Multiple sclerosis is one of the most prevalent neurological diseases in young adults affecting over 2 million people worldwide. Alemtuzumab a highly effective therapy relapsing remitting MS. monoclonal CD52 antibody that proved its efficacy against an active comparator (interferon [IFN]-β1a) phase II trial and two III trials regarding clinical MRI outcomes. Nevertheless, exact mode action still unknown. commonly associated with secondary autoimmune disorders...