Lucas Treps
A5027063148- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cancer Cells and Metastasis
- Congenital heart defects research
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Axon Guidance and Neuronal Signaling
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Peroxisome Proliferator-Activated Receptors
- Hippo pathway signaling and YAP/TAZ
- Glioma Diagnosis and Treatment
- Cystic Fibrosis Research Advances
- Barrier Structure and Function Studies
- Nitric Oxide and Endothelin Effects
- RNA modifications and cancer
- Biomarkers in Disease Mechanisms
- Apelin-related biomedical research
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
Inserm
2013-2025
Centre National de la Recherche Scientifique
2014-2025
Nantes Université
2016-2025
Université d'Angers
2016-2025
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2022-2025
VIB-KU Leuven Center for Cancer Biology
2016-2024
KU Leuven
2016-2024
Research Centre for Medical Genetics
2019
Hôpital Cochin
2019
Assistance Publique – Hôpitaux de Paris
2019
Abstract Mutations in the cytosine‐5 RNA methyltransferase NSun2 cause microcephaly and other neurological abnormalities mice human. How post‐transcriptional methylation contributes to human disease is currently unknown. By comparing gene expression data with global methylomes patient fibroblasts NSun2‐deficient mice, we find that loss of increases angiogenin‐mediated endonucleolytic cleavage transfer RNAs ( tRNA ) leading an accumulation 5′ ‐derived small fragments. Accumulation fragments...
Glioblastoma multiforme (GBM) are mortifying brain tumours that contain a subpopulation of tumour cells with stem-like properties, termed glioblastoma (GSCs). GSCs largely contribute to initiation, propagation and resistance current anti-cancer therapies. situated in perivascular niches, closely associated microvascular endothelial cells, thereby involved bidirectional molecular cellular interactions. Moreover, extracellular vesicles suspected carry essential information can adapt the...
Abstract Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is lacking, here we perform single RNA-sequencing 26,515 cells (including 8433 ECs) from 9 BC patients and compare them to published EC taxonomies lung tumors. Angiogenic ECs are phenotypically similar, while other subtypes different. Predictive interactome analysis reveals known but also previously unreported receptor-ligand interactions between immune cells, suggesting an involvement responses....
Tumor vessel co-option is poorly understood, yet it a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer myeloid in tumors growing via co-option, has not been investigated at the single-cell level. Here, we use murine AAT-resistant lung tumor model, which VEGF-targeting induces for continued growth. Single-cell RNA sequencing (scRNA-seq) 31,964 reveals, unexpectedly, largely similar transcriptome...
Glioblastoma are highly aggressive brain tumours that associated with an extremely poor prognosis. Within these exists a subpopulation of plastic self-renewing cancer cells retain the ability to expand ex vivo as tumourspheres, induce tumour growth in mice, and have been implicated radio- chemo-resistance. Although their identity fate regulated by external cues emanating from endothelial cells, nature such signals remains unknown. Here, we used mass spectrometry proteomic approach...
VE-cadherin-mediated cell-cell junction weakening increases paracellular permeability in response to both angiogenic and inflammatory stimuli. Although Semaphorin 3A has emerged as one of the few known anti-angiogenic factors exhibit pro-permeability activity, little is about how it triggers vascular leakage. Here we report that induced VE-cadherin serine phosphorylation internalization, destabilization, loss barrier integrity brain endothelial cells. In addition, high-grade glioma-isolated...
Endothelial cells (ECs) line blood vessels, regulate homeostatic processes (blood flow, immune cell trafficking), but are also involved in many prevalent diseases. The increasing use of high-throughput technologies such as gene expression microarrays and (single cell) RNA sequencing generated a wealth data on the molecular basis EC (dys-)function. Extracting biological insight from these datasets is challenging for scientists who not proficient bioinformatics. To facilitate re-use publicly...
The amount of biological data, generated with (single cell) omics technologies, is rapidly increasing, thereby exacerbating bottlenecks in the data analysis and interpretation experiments. Data mining platforms that facilitate non-bioinformatician experimental scientists to analyze a wide range designs types can alleviate such bottlenecks, aiding exploration (newly or publicly available) datasets. Here, we present BIOMEX, browser-based software, designed Biological Interpretation Of...