A5101879609- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Angiogenesis and VEGF in Cancer
- Connexins and lens biology
- Hippo pathway signaling and YAP/TAZ
- Protein purification and stability
- Trace Elements in Health
- Intraocular Surgery and Lenses
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Mercury impact and mitigation studies
- Monoclonal and Polyclonal Antibodies Research
- Bone and Dental Protein Studies
- COVID-19 and Mental Health
- Cell Adhesion Molecules Research
- Hair Growth and Disorders
- Vanadium and Halogenation Chemistry
- Glaucoma and retinal disorders
- Ureteral procedures and complications
- Parathyroid Disorders and Treatments
- Advanced Drug Delivery Systems
- Tendon Structure and Treatment
- Lung Cancer Treatments and Mutations
- Retinal and Macular Surgery
- Healthcare and Venom Research
Jining Medical University
2023-2024
Shanghai University of Sport
2020-2023
Institute of Process Engineering
2021-2022
China University of Mining and Technology
2021-2022
Washington State University
2022
Sun Yat-sen University
2016-2020
Florida Hospital Medical Group
2019
Zhongshan Ophthalmic Center, Sun Yat-sen University
2018
Robert Koch Institute
2016
Shandong University of Traditional Chinese Medicine
2013-2015
Significance Despite being discovered a long time ago, the functional properties of VEGF-B remain poorly understood. However, several clinical treatments use drugs that target and other VEGF family members. It is therefore crucial to gain deeper insights into function underlying mechanisms. Here, we found has potent antioxidative functions, making it member show such property. We further identified critical downstream effector VEGF-B, Gpx1, through which protects against retinal...
Significance Caveolin-1 (Cav-1) is a major structural protein of caveolae found in cell membranes and critical for numerous cellular functions. However, it remains unclear whether Cav-1 plays role ocular neovascularization, cause blindness. In this study, we that the gene deletion exacerbates cavtratin, permeable peptide mimicking function, inhibits neovascularization by targeting multiple components angiogenesis. Importantly, combined administration cavtratin anti–VEGF-A more effectively,...
Abstract Currently, titanium dioxide nanoparticles (TiO 2 NP s) have been widely used in various applications including cosmetics, food additives and biomedicine. However, there are few reports available using TiO s to treat ocular diseases. Posterior capsular opacification ( PCO ) is the most frequent complication after cataract surgery, which induced by proliferation migration of lens epithelial cells. Thus, inhibiting cells will efficiently reduce occurrence . In this study, we...
Whereas retinal pigment epithelial (RPE) cells are known to secrete VEGF-A and VEGFR2, the functions of autocrine VEGF signaling remain unclear. Meanwhile, anti-VEGF therapies have been applied routinely treat ocular vascular diseases.The aim this study was determine in RPE evaluate consequences its interruption.The genes involved Hippo signal pathways were knocked down with siRNAs both ARPE-19 cell line human primary via transient transfection whereas overexpression VEGFR2 mediated...
Anti-VEGF-A therapy has proven to be effective for many neovascular diseases. However, drug resistance anti-VEGF-A treatment can develop. Also, not all patients with diseases are responsive treatment. The mechanisms underlying these important issues remain unclear. In this study, using different model systems, we found that inhibition of VEGF-A directly upregulated PDGF-CC and its receptors in multiple cell types pathological angiogenesis vitro vivo. Importantly, further revealed...
Junctional adhesion molecule-C (JAM-C) has been shown to play critical roles during development and in immune responses. However, its role adult eyes under oxidative stress remains poorly understood. Here, we report that JAM-C is abundantly expressed mouse retinae choroids vivo cultured retinal pigment epithelium (RPE) photoreceptor cells vitro. Importantly, both expression membrane localisation are downregulated by H2O2-induced stress. Under stress, critically required for the survival of...