A5013066671- Colorectal Cancer Surgical Treatments
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- COVID-19 and healthcare impacts
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Anorectal Disease Treatments and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Cancer-related gene regulation
- Healthcare cost, quality, practices
- Tannin, Tannase and Anticancer Activities
- Medical Practices and Rehabilitation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Trauma and Emergency Care Studies
- Colorectal Cancer Screening and Detection
- Molecular Biology Techniques and Applications
- Healthcare professionals’ stress and burnout
- Global Cancer Incidence and Screening
- Wnt/β-catenin signaling in development and cancer
- Mobile Health and mHealth Applications
University Hospital Carl Gustav Carus
2016-2025
Helmholtz-Zentrum Dresden-Rossendorf
2021-2025
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2015-2025
National Center for Tumor Diseases
2021-2024
German Cancer Research Center
2011-2023
Heidelberg University
2011-2023
Technische Universität Dresden
2015-2023
Charité - Universitätsmedizin Berlin
2002-2022
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
We have previously identified a 115-gene signature that characterises the metastatic potential of human primary colon cancers. The included canonical Wnt target gene BAMBI, which promoted experimental metastasis in mice. Here, we three new direct genes from signature, and studied their functions epithelial-mesenchymal transition (EMT), cell migration metastasis.We examined liver metastases following injection selected tumour cells into spleens NOD/SCID Molecular cellular techniques were used...
Abstract Purpose: Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in tumor invasion and dissemination. EMT occurs predominantly at the edge where it is induced by cytokines, extracellular matrix environment, or hypoxia. In cell, further mediated several transcription factors microRNAs. The aim of this study was to explore expression EMT-associated genes invasive front colorectal cancer evaluate their prognostic significance. Experimental Design: We evaluated 13 30 liver...
Transcriptional signatures are an indispensible source of correlative information on disease-related molecular alterations a genome-wide level. Numerous candidate genes involved in disease and factors predictive, as well prognostic, value have been deduced from such portraits, e.g. cancer. However, mechanistic insights into the regulatory principles governing global transcriptional changes lagging behind extensive compilations deregulated genes. To identify regulators transcriptome...
Complex oncological procedures pose various surgical challenges including dissection in distinct tissue planes and preservation of vulnerable anatomical structures throughout different phases. In rectal surgery, violation increases the risk local recurrence autonomous nerve damage resulting incontinence sexual dysfunction. This work explores feasibility phase recognition target structure segmentation robot-assisted resection (RARR) using machine learning.A total 57 RARR were recorded subsets...
Survivin is described as a bifunctional protein inhibiting apoptosis and regulating mitosis. However, the biological functions contributions to cancer progression of survivin splice variants are controversially discussed. We here show that intracellular localization these depends on Crm1-dependent nuclear export signal (NES) present in survivin, surviving(-2B) survivin(-3B), but absent survivin(-deltaEx3) survivin(-2alpha). isoforms lack an active import able enter nucleus by passive...
The tumor edge of colorectal cancer and its adjacent peritumoral tissue is characterized by an invasion front-specific expression genes that contribute to angiogenesis or epithelial-to-mesenchymal transition. Dysregulation these has a strong impact on the behavior cells. However, microRNA (miRNA) still remains unclear. Therefore, aim present study was investigate miRNA patterns at front liver metastases. Laser microdissection metastases performed obtain separate compartments from center,...
Digitalization is a disruptive technology that changes the way we deliver diagnostic procedures and treatments in medicine. Different stakeholders have varying interests expectations of digitalization modern Many recent digital advances medical field, such as implementation electronic health records, telemedical services, mobile apps, are increasingly used by professionals patients. During current pandemic outbreak novel coronavirus-caused respiratory disease (COVID-19), many information...
Epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC) contribute to tumour progression metastasis. Assessment of transcription factors involved in these two mechanisms can help identify new targets for an oncological therapy. In this study, we focused on the evaluation factor Six1 (Sine oculis 1). This protein is embryologic development its contribution carcinogenesis has been described several studies.Immunohistochemistry against was performed a tissue microarray containing...
Abstract Background Previous studies have demonstrated stapler hepatectomy and use of various energy devices to be safe alternatives the clamp-crushing technique in elective hepatic resection. In this randomized trial, effectiveness safety were compared with those parenchymal transection LigaSure™ vessel sealing system. Method Patients scheduled for liver resection at two tertiary-care centres during surgery or device. Total intraoperative blood loss was primary efficacy endpoint....
Pelvic exenteration (PE) is the only option for long-term cure of advanced cancer originating from different types tumor or recurrent disease in lower pelvis. The aim was to show differences between colorectal and non-colorectal survival postoperative morbidity.Retrospective data 63 patients treated with total pelvic 2013 2018 are reported. Pre-, intra-, parameters, data, risk factors complications were analyzed.A 57.2% (n = 37) had cancer, 22.3% gynecological malignancies (vulvar 6)...
In tumor cells, stepwise oncogenic deregulation of signaling cascades induces alterations cellular morphology and promotes the acquisition malignant traits. Here, we identified a set 21 genes, including FGF9, as determinants cell by an RNA interference phenotypic screen in SW480 colon cancer cells. Using panel small molecular inhibitors, subsequently established effects, downstream cascades, associated gene expression signatures FGF receptor signals. We found that inhibition signals...
Abstract Purpose To compare the diagnostic performance of 18 F-fluorodeoxyglucose-PET/MRI and MRI in diagnosis pelvic recurrence rectal cancer. Methods All PET/MRIs patients follow-up cancer performed between 2011 2018 at our institution were retrospectively reviewed. Recurrence was confirmed/excluded either by histopathology or imaging (> 4 months). Four groups readers (groups 1/2: one radiologist each, 3/4: radiologist/one nuclear medicine physician) independently interpreted PET/MRI....
Introduction: During the first wave of COVID-19 pandemic in 2020, German government implemented legal restrictions to avoid overloading intensive care units by patients with COVID-19. The influence these effects on diagnosis and treatment cancer Germany is largely unknown. Methods: To evaluate effect tumor board presentations a high-volume tertiary referral center (the Comprehensive Cancer Center NCT/UCC Dresden), we compared number gastrointestinal tumors stratified entity, stage, intention...
We have previously reported that over-expression of a panel 119 genes correlates with the metastatic potential pancreatic carcinoma cells. sought to identify and functionally characterize candidate tumour metastasis promoting among this library using secondary phenotype-assisted screen. Here we report discovery metastasis-promoting function hitherto not characterized gene located on chromosome 14 (ORF138), which named 'novel 1' (NVM-1). The NVM-1 transcript is extensively alternatively...
Abstract Introduction Complex oncological procedures pose various surgical challenges including dissection in distinct tissue planes and preservation of vulnerable anatomical structures throughout different phases. In rectal surgery, violation increases the risk local recurrence autonomous nerve damage resulting incontinence sexual dysfunction. This work explores feasibility phase recognition target structure segmentation robot-assisted resection (RARR) using machine learning. Materials...
Translational research is important, especially in medicine where decisions affect people's lives. Clinical registries and the studies embedded them allow depiction of actual care practice under routine conditions. Translating findings health services back into clinical through prospective cohort has potential to drive medical innovations faster, more effectively and, above all, a targeted manner. These must therefore be central component cutting-edge oncological research.
Introduction: Bone sarcoma or direct pelvic carcinoma invasion of the sacrum represent indications for partial total sacrectomy. The aim was to describe oncosurgical management and complication profile analyze our own outcome results following Methods: In a retrospective analysis, 27 patients (n = 8/10/9 sarcoma/chordoma/locally recurrent rectal cancer (LRRC)) were included. There sacrectomy in 9 (incl. combined L5 en bloc spondylectomy 2), 10 hemisacrectomy 8 patients. 12 patients,...
Anastomotic leakage (AL) and surgical site infection (SSI) account for most postoperative complications in colorectal surgery. The aim of this retrospective trial was to investigate whether perioperative selective decontamination the digestive tract (SDD) reduces these provide a cost-effectiveness model elective surgery.All patients operated between November 2016 March 2020 were included our analysis. Patients primary cohort (PC) received SDD those historical control (CC) did not receive...