A5014194857- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- Phagocytosis and Immune Regulation
- Bayesian Modeling and Causal Inference
- Statistical Methods and Bayesian Inference
- Cancer Genomics and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Migraine and Headache Studies
- Advanced Statistical Methods and Models
- Education, Psychology, and Social Research
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Statistical Methods in Clinical Trials
- Neuroendocrine Tumor Research Advances
- COVID-19 Impact on Reproduction
- Advanced Causal Inference Techniques
- Helicobacter pylori-related gastroenterology studies
- Pancreatitis Pathology and Treatment
- Data Mining Algorithms and Applications
- Rough Sets and Fuzzy Logic
- Bioinformatics and Genomic Networks
- Olfactory and Sensory Function Studies
Helmholtz-Zentrum Dresden-Rossendorf
2021-2025
University Hospital Carl Gustav Carus
2019-2025
National Center for Tumor Diseases
2016-2025
Technische Universität Dresden
2019-2025
German Cancer Research Center
2020-2025
Heidelberg University
2020-2025
University Hospital Heidelberg
2023-2024
Zimmer Biomet (United States)
2024
Zimmer Biomet (Germany)
2020-2023
Carl Gustav Carus-Institut
2021
Dialysis and kidney transplant patients are vulnerable populations for COVID-19 related disease mortality.
Patterns of genetic alterations characterize different molecular subtypes human gastric cancer. We aimed to establish mouse models these subtypes.We searched databases identify genes with unique expression in the stomach epithelium, resulting identification Anxa10. generated mice tamoxifen-inducible Cre recombinase (CreERT2) Anxa10 gene locus. created 3 pathways that chromosomal instability (CIN) and genomically stable (GS) cancer: Anxa10-CreERT2;KrasG12D/+;Tp53R172H/+;Smad4fl/f (CIN mice),...
T cells are the predominant immune cell population in pancreatic tumor microenvironment. High CD8+ and Th1-polarized CD4+ infiltration is associated with prolonged survival human ductal adenocarcinoma (PDAC). However, expression pattern of co-stimulatory inhibitory receptors by PDAC-infiltrating their prognostic significance not well defined. In this study, we employed multiplex immunofluorescence to investigate intratumoral receptor inducible T-cell co-stimulator (ICOS),...
Abstract Drug combination therapies for cancer treatment show high efficacy but often induce severe side effects, resulting in dose or cycle number reduction. We investigated the impact of neoadjuvant chemotherapy (neoCTx) adaptions on outcome 59 patients with pancreatic ductal adenocarcinoma (PDAC). Resections tumor‐free margins were significantly more frequent when full‐dose neoCTx was applied. determined if patient‐derived organoids (PDOs) can be used to personalize poly‐chemotherapy...
Abstract Recent technological advances have made Virtual Reality (VR) attractive in both research and real world applications such as training, rehabilitation, gaming. Although these other fields benefited from VR technology, it remains unclear whether contributes to better spatial understanding training the context of surgical planning. In this study, we evaluated use by comparing recall information two learning conditions: a head-mounted display (HMD) desktop screen (DT). Specifically,...
EGFR exon 20 (EGFR Ex20) insertion mutations in non-small cell lung cancer (NSCLC) are insensitive to traditional tyrosine kinase inhibitors (TKIs). Mobocertinib is the only approved TKI specifically designed target Ex20. We performed an international, real-world safety and efficacy analysis on patients with Ex20-positive NSCLC enrolled a mobocertinib early access program. explored mechanisms of resistance by analyzing postprogression biopsies, as well cross-resistance amivantamab. Data from...
Abstract Purpose: Immunotherapy has led to a fundamental shift in the treatment of several cancers. However, its efficacy pancreatic ductal adenocarcinoma (PDAC) is limited. Understanding expression inhibitory immune checkpoint receptors (ICR) by intratumoral T cells may help unravel their involvement insufficient T-cell–mediated antitumor immunity. Experimental Design: Using multicolor flow cytometry, we analyzed circulating and from blood (n = 144) matched tumor samples 107) patients with...
Abstract Orderly chromosome segregation is enabled by crossovers between homologous chromosomes in the first meiotic division. Crossovers arise from recombination-mediated repair of programmed DNA double-strand breaks (DSBs). Multiple DSBs initiate recombination, and most are repaired without crossover formation, although one or more generate on each chromosome. Although underlying mechanisms ill-defined, differentiation maturation crossover-specific recombination intermediates requires...
Postpancreatectomy haemorrhage (PPH) is a rare but potentially fatal complication after pancreatoduodenectomy. Preventive strategies are lacking with scarce data for support. The aim of this study was to investigate whether prophylactic falciform ligament wrap around the hepatic and gastroduodenal artery can prevent PPH from these vessels.In randomized, controlled, multicentre trial, patients who were scheduled elective open partial pancreatoduodenectomy pancreatojejunostomy between 5...
Abstract Objectives As robot-assisted surgery (RAS) is on the rise, feasible and effective simulator training for surgical residents needed. This study compares effectiveness feasibility of two compact protocols DaVinci skills (dVSS) preparing robotic novices. Methods In this randomized controlled trial, RAS novices were 1:1 into a conventional group (Control), including four repetitions five exercises in sessions, fast (Fast), with same single session. The primary endpoint was mean...
Headache in pupils is underestimated and has a negative impact on learning life. The aim of this study was to investigate headache prevalence its collateral effects, different ages school types German city.Anonymized questionnaires were distributed 5419 attending primary secondary schools. Demographics, frequency, analgesic use, absence and, for children, data lifestyle collected.The questionnaire returned by 2706 children (49%), 1362 (50.3%) girls, 1344 (49.7%) boys. Of these, 36.6%...
Currently, voided urine cytology (VUC) serves as the gold standard for detection of bladder cancer (BCa) in urine. Despite its high specificity, VUC has shortcomings terms sensitivity. Therefore, alternative biomarkers are being searched, which might overcome these disadvantages a useful adjunct to VUC. The aim this study was evaluate diagnostic potential urinary levels selected microRNAs (miRs), represent such due their BCa-specific expression. Expression nine BCa-associated (miR-21, -96,...
Sensitization to sensory stimuli is an essential feature of migraine attacks. The relationship between the clinical course and increased sensitivity olfactory has been little studied so far.We analyzed frequency quality osmophobia depending on phase in patients with episodic chronic treated tertiary headache center regard gender, age, medical history disability assessment score (MIDAS). Standardized diagnostic questions were used for osmophobia.In our cross-sectional investigation (n = 113),...
Recent studies investigated the potential of large language models (LLMs) for clinical decision making and answering exam questions based on text input. developments LLMs have extended these with vision capabilities. These image processing are called vision-language (VLMs). However, there is limited investigation applicability VLMs their capabilities content. Therefore, aim this study was to examine performance publicly accessible in 2 different surgical question sets consisting questions....
Objective: To quantify and characterize preoperative blood T cells in patients with pancreatic ductal adenocarcinoma (PDAC), who underwent tumor resection, to determine their relevance as biomarkers for postoperative pancreas-specific complications. Background: Pancreas-specific complications after surgery are associated a high morbidity mortality, which both deprive of adjuvant chemotherapy. Noninvasive risk prediction missing, the role stratification is unknown. Methods: The frequency cell...
Headache prevalence among children and adolescents has increased over the last few years. Evidence-based treatment options for pediatric headaches remain limited. Research suggests a positive influence of odors on pain mood. We investigated effect repeated exposure to perception, headache-related disability, olfactory function in with primary headaches.Eighty patients migraine or tension-type headache (mean 13.1 ± 3.29 years) participated, whom 40 underwent daily training individually...
Abstract The paper describes a generalized iterative proportional fitting procedure that can be used for maximum likelihood estimation in special class of the general log‐linear model. models this class, called relational, apply to multivariate discrete sample spaces do not necessarily have Cartesian product structure and may contain an overall effect. When applied cell probabilities, without effect are curved exponential families values sufficient statistics reproduced by MLE only up...
Kidney transplant recipients (KTR) show significantly lower seroconversion rates after SARS-CoV-2 mRNA vaccination compared to dialysis patients (DP). Mycophenolate mofetil or mycophenolic acid (MMF/MPA) in particular has been identified as a risk factor for failure. While the majority of all KTR worldwide receive MMF/MPA immunosuppressive therapy, its impact on antibody decline seroconverted still remains unclear. In an observational study (NCT04799808), we investigated whether 132...
Introduction: During the first wave of COVID-19 pandemic in 2020, German government implemented legal restrictions to avoid overloading intensive care units by patients with COVID-19. The influence these effects on diagnosis and treatment cancer Germany is largely unknown. Methods: To evaluate effect tumor board presentations a high-volume tertiary referral center (the Comprehensive Cancer Center NCT/UCC Dresden), we compared number gastrointestinal tumors stratified entity, stage, intention...
Background While anti-SARS-CoV-2 vaccination success in kidney transplant recipients (KTR) after two doses and 1273-mRNA was associated with higher seroconversion rates compared to BNT162b2-mRNA our “DIA-Vacc Study” (NCT04799808), it remains unclear whether this may also be the case non-responding KTR a third dose. Materials Methods Non-responding (after mRNA vaccinations) were investigated 4.5–6 months study enrollment at first vaccination. One hundred sixty-six of 193 received between 3.5...