A5050650061- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Nitric Oxide and Endothelin Effects
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Chronic Kidney Disease and Diabetes
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
- Eicosanoids and Hypertension Pharmacology
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Dialysis and Renal Disease Management
- Peroxisome Proliferator-Activated Receptors
- Adrenal and Paraganglionic Tumors
- Lymphatic System and Diseases
- Cardiovascular Health and Disease Prevention
- COVID-19 Impact on Reproduction
- Inflammatory Biomarkers in Disease Prognosis
- Apelin-related biomedical research
- Heart Rate Variability and Autonomic Control
Technische Universität Dresden
2004-2022
University Hospital Carl Gustav Carus
2005-2021
PHV Dialysezentrum
2018-2021
Klinikum Görlitz
2021
GWT-TUD (Germany)
2010-2017
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2009-2015
Center for Clinical Studies
2012
Praxis
2010
University of Cologne
2007
Klinikum Weiden
2007
Dialysis and kidney transplant patients are vulnerable populations for COVID-19 related disease mortality.
OBJECTIVE—Insulin resistance is an independent risk factor for arteriosclerosis and cardiovascular mortality. However, the mechanism by which insulin contributes to unknown. Conceivably, endothelial dysfunction could be involved. Therefore, we asked whether therapy ameliorates any dysfunction. RESEARCH DESIGN AND METHODS—We performed a double-blind cross-over trial of 12 patients with recently diagnosed type 2 diabetes. They received rosiglitazone 4 mg b.i.d. weeks nateglinide 60 same number...
In patients with type 2 diabetes and cardiovascular diseases (CVDs), intensive treatment insulin and/or sulfonylurea (SU) may be associated excessive increased risk of hypoglycemic episodes. To evaluate the critical arrhythmias related to glycemic variability, we carried out an observational study in CVD.Thirty documented CVD who had been treated SU underwent 5 days monitoring a continuous glucose measurement system along parallel electrocardiogram recording for ventricular arrhythmias....
Severe hypoglycemia is recognized to be one of the strongest predictors macrovascular events, adverse clinical outcomes, and mortality in patients with type 2 diabetes. However, it uncertain whether a direct pathophysiological link exists or primarily marker vulnerability these events. Large trials have reported an increased hazard ratio for all-cause cardiovascular events diabetes severe hypoglycemia, but such association has not been demonstrated prospective people 1 Several effects occur...
Microalbuminuria, an early feature of diabetic nephropathy, indicates intrarenal endothelial damage. In type 2 diabetes, microalbuminuria is strongly related to insulin resistance. We therefore investigated whether rosiglitazone, insulin-sensitizing drug that known improve dysfunction, was able dysfunction and microalbuminuria. Nineteen patients participated in this double-blind cross-over trial. Nine with newly diagnosed disease without were randomized a treatment rosiglitazone or...
Patients with diabetes show an increased vascular morbidity and mortality that reduces their life expectancy by ~5–15 years (depending on the age at diagnosis) (1). There is convincing evidence from epidemiological pathophysiological studies hyperglycemia per se largely responsible for harmful effects of disease. As recently shown clinical trials, treatment this condition may reduce cardiovascular events mortality, several therapies should be considered: initiating early individualized...
Current concepts for the explanation of endothelial dysfunction and accelerated atherosclerosis in uremia propose a reduced vascular bioavailability nitric oxide (NO). The aim present study was to test contributions NO NO/prostacyclin (PGI(2))-independent mechanisms both baseline tone agonist-induced endothelium-dependent vasodilation patients on hemodialysis (HD). In 10 HD eight matched healthy control subjects, forearm blood flow (FBF) measured at rest during intrabrachial infusions...
Platelets from patients with type 2 diabetes mellitus display hyperaggregability and increased thrombogenic potential.In platelets mellitus, we found enhanced tyrosine nitration inactivation of the sarcoplasmic endoplasmic reticulum Ca2+-ATPase (SERCA-2), elevated platelet [Ca2+]i, activation mu-calpain. The SERCA-2 mu-calpain in vitro healthy volunteers could be evoked by peroxynitrite. Platelet endothelial cell adhesion molecule-1 was identified as a substrate; its degradation stimulated...
Background. The evidence base regarding the safety of intravenous (IV) iron therapy in patients with chronic kidney disease (CKD) is incomplete and largely based on small studies relatively short duration. Methods. FIND-CKD (ClinicalTrials.gov number NCT00994318) was a 1-year, open-label, multicenter, prospective study nondialysis-dependent CKD, anemia deficiency randomized (1:1:2) to IV ferric carboxymaltose (FCM), targeting higher (400–600 µg/L) or lower (100–200 ferritin, oral iron. A...
We investigated whether basal insulin as first-line treatment in recently diagnosed type 2 diabetes (T2D) can improve glucose control, microvascular function and preserve secretion comparison with metformin (MET). In this open-label, randomized, prospective 36-week study, 75 patients (44 m, 31 f, mean age 60.7 ± 9.2 year) were allocated to either MET 1,000 mg b.i.d. (n = 36) or glargine (GLA) at bedtime 39). At baseline study end, we performed a continuous monitoring for assessment of...
Hypertension and hyperglycemia are established risk factors for progression of microangiopathies macroangiopathies in type 2 diabetes mellitus. Cardiovascular is even more increased diabetic patients with nocturnal nondipping or postprandial hyperglycemia. We therefore investigated the relationship between diurnal blood pressure (BP) variation patients. One hundred seven hypertensive received a 24-h ambulatory BP recording. In addition, glucose profile was assessed under standardized...
Our objective was to determine the role of Rho-associated kinase (ROK) for regulation FBF (FBF) and unmask a potential ROK endothelium-derived nitric oxide (NO). Moreover, effect fasudil on constrictor response endothelin-1 recorded. Regarding background, phosphorylation myosin light chain (MLC) determines calcium sensitivity contractile apparatus. MLC depends activity phosphatase. The latter enzyme is inhibited through by ROK. has been suggested inhibit NO generation, possibly via...
Endothelial progenitor cells (EPC) are involved in endothelial repair and maintenance. Dysfunction of EPC may contribute to accelerated arteriosclerosis chronic kidney disease. Kidney transplantation (KTx) improves both survival function dialysis patients. In a prospective study, we tested which extent KTx changes biology. We studied number (migratory activity, adhesion extracellular matrix proteins mature [EC]) 20 patients during 3, 6, 9 12 months after KTx. Twenty-two healthy volunteers...
Proteinuria in diabetic nephropathy predicts the progressive loss of glomerular filtration rate (GFR) and serves as independent predictor for mortality. We performed present study (ClinicalTrials.gov identifier: NCT 00324675) to clarify whether activation PPARγ receptor by thiazolidinediones was able improve proteinuria preserve renal function advanced nephropathy. A total 28 type 2 patients (4 women 24 men, mean age 66.1±9.1 years) with urinary albumin excretion >300 mg/24 h an estimated...