A5100458890- Cancer Research and Treatments
- Streptococcal Infections and Treatments
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Enzyme Production and Characterization
- Microbial Community Ecology and Physiology
- Bacterial Genetics and Biotechnology
- Chromium effects and bioremediation
- Fungal and yeast genetics research
- Enzyme Structure and Function
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Microbial bioremediation and biosurfactants
- Electrochemical sensors and biosensors
- Photosynthetic Processes and Mechanisms
- Adsorption and biosorption for pollutant removal
- Pharmaceutical and Antibiotic Environmental Impacts
- Biofuel production and bioconversion
- Polysaccharides and Plant Cell Walls
- Genomics and Phylogenetic Studies
- Hemoglobin structure and function
- Microbial Metabolic Engineering and Bioproduction
- Environmental remediation with nanomaterials
Tianjin University of Science and Technology
2020-2025
Abstract Background Genome reduction and metabolic engineering have emerged as intensive research hotspots for constructing the promising functional chassis various microbial cell factories. Surfactin, a lipopeptide-type biosurfactant with broad spectrum antibiotic activity, has wide application prospects in anticancer therapy, biocontrol bioremediation. Bacillus amyloliquefaciens LL3, previously isolated by our lab, contains an intact srfA operon genome surfactin biosynthesis. Results In...
Hyaluronic acid (HA) is extensively employed in various fields such as medicine, cosmetics, food, etc. The molecular weight (MW) of HA crucial for its biological functions. Streptococcus zooepidemicus, a prominent industrial producer, naturally synthetizes with high MW. Currently, few effective approaches exist the direct and precise regulation MW through one-step fermentation process, S. zooepidemicus lacks metabolic regulatory elements varying intensities. ratio HA's precursors,...
Aspergillus niger has shown great potential for hexavalent chromium [Cr(VI)] bioremediation in wastewater treatment. However, the specific functional genes involved Cr(VI) removal pathway A. remain unexplored, limiting our ability to create genetically engineered strains with enhanced capabilities. In this study, we successfully identified two critical responsible chromate removal: chrR, a putative gene encoding reductase, and chrP, permease. Our findings revealed that deletion of either...
Kojic acid (KA) is a widely used compound in the cosmetic, medical, and food industries, typically produced by Aspergillus oryzae. To meet increasing market demand, it important to optimize KA production through seeking alternatives that are more economic than current A. oryzae-based methods.In this study, we achieved first successful heterologous of niger, an industrially fungus does not naturally produce KA, expression kojA gene from Using resulting KA-producing niger strain as platform,...
Citric acid is widely used in the food, chemical and pharmaceutical industries. Aspergillus niger workhorse for citric production industry. A canonical citrate biosynthesis that occurred mitochondria was well established; however, some research suggested cytosolic pathway may play a role this production. Here, roles of phosphoketolase (PK), acetate kinase (ACK) acetyl-CoA synthetase (ACS) were investigated by gene deletion complementation A. niger. The results indicated PK, ACK ACS important...
Abstract Background: Genome reduction and metabolic engineering have emerged as intensive research hotspots for constructing the promising functional chassis various microbial cell factories. Surfactin, a lipopeptide-type biosurfactant with broad spectrum antibiotic activity, has wide application prospects in anticancer therapy, biocontrol bioremediation. Bacillus amyloliquefaciens LL3, previously isolated by our lab, contains an intact srfA operon genome surfactin biosynthesis. Results: In...
Abstract Background: Genome reduction and metabolic engineering have emerged as intensive research hotspots for constructing the promising functional chassis various microbial cell factories. Surfactin, a lipopeptide-type biosurfactant with broad spectrum antibiotic activity, has wide application prospects in anticancer therapy, biocontrol bioremediation. Bacillus amyloliquefaciens LL3, previously isolated by our lab, contains an intact srfA operon genome surfactin biosynthesis. Results: In...
Abstract Background: Genome reduction and metabolic engineering have emerged as intensive research hotspots for constructing the optimal functional chassis various microbial cell factories. Surfactin, a lipopeptide-type biosurfactant with broad spectrum antibiotic activity, has wide application prospects in anticancer therapy, biocontrol bioremediation. Bacillus amyloliquefaciens LL3, previously isolated by our lab, contains an intact srfA operon genome surfactin biosynthesis. Results: In...
Abstract Background: Genome reduction and metabolic engineering have emerged as intensive research hotspots for constructing the promising functional chassis various microbial cell factories. Surfactin, a lipopeptide-type biosurfactant with broad spectrum antibiotic activity, has wide application prospects in anticancer therapy, biocontrol bioremediation. Bacillus amyloliquefaciens LL3, previously isolated by our lab, contains an intact srfA operon genome surfactin biosynthesis. Results: In...