A5040592673- Acupuncture Treatment Research Studies
- Renal Diseases and Glomerulopathies
- Traditional Chinese Medicine Studies
- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Functional Brain Connectivity Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Tryptophan and brain disorders
- Renal cell carcinoma treatment
- Gut microbiota and health
- Genetic Associations and Epidemiology
- Heart rate and cardiovascular health
- Atherosclerosis and Cardiovascular Diseases
- Motor Control and Adaptation
- Cancer-related cognitive impairment studies
- Traditional Chinese Medicine Analysis
- Bone health and osteoporosis research
- Balance, Gait, and Falls Prevention
- Pharmacological Effects of Natural Compounds
- BRCA gene mutations in cancer
- Genetic Syndromes and Imprinting
- Natural Compounds in Disease Treatment
- Vasculitis and related conditions
- Liver Disease Diagnosis and Treatment
Sir Run Run Shaw Hospital
2023-2025
Zhejiang University
2023-2025
China Jiliang University
2022-2025
Beijing University of Chinese Medicine
2021-2024
Yangzhou University
2024
Triptolide, a major active ingredient isolated from Tripterygium wilfordii Hook f., is effective in the treatment of membranous nephropathy (MN); however, its pharmacological mechanism action has not yet been clarified. We applied an approach that integrated network pharmacology and experimental validation to systemically reveal molecular triptolide MN.First, potential targets MN-related were collected publicly available database. Then, based on protein-protein interaction as well GO KEGG...
Hypertensive nephropathy (HTN) is the second leading cause of end-stage renal disease (ESRD) and a chronic inflammatory disease. Persistent hypertension leads to lesions intrarenal arterioles arterioles, luminal stenosis, secondary ischemic parenchymal damage, glomerulosclerosis, tubular atrophy, interstitial fibrosis. Studying pathogenesis hypertensive prerequisite for diagnosis treatment. The main HTN poor long-term blood pressure control, but kidney damage often accompanied by occurrence...
Background: Colorectal cancer and Alzheimer’s disease are both common life-threatening diseases in the elderly population. Some studies suggest a possible inverse relationship between colorectal disease, but real-world research is subject to many biases. We hope clarify causal two through bidirectional two-sample Mendelian randomization study. Methods: In our study, we used genetic summary data from large-scale genome-wide association investigate disease. Our primary analysis employed...
This research is the first to report phytochemical investigation of Strobilanthes sarcorrhiza C. Ling. Thirty-three compounds were isolated and characterised (1 32), including a pair undescribed isomers (1a 1b), one phenolics (16), 30 known compounds. Their structures assessed via spectroscopic chemical data. The protective effect all (62.5–500 nM) against lipopolysaccharide (LPS)-induced cytotoxicity in RAW 264.7 was tested. Compounds 1a, 1b, 10, 11–17, 21, 24, 28–32 showed significant...
Hypertensive nephropathy (HN), caused by long-term poorly controlled hypertension, is the second common cause of end-stage renal disease after diabetes mellitus, but pathogenesis HN unclear. The purpose this study was to identify biological pathways involved in progression and bile acid (BA)-related biomarkers, analyze role acids HN. Download gene microarray data from Gene Expression Omnibus. Differentially expressed genes (DEGs) associated with were identified, then DEGs subjected Ontology...
Introduction Chronic hypertension may have a contributory role toward cognitive impairment. Acupuncture exerts protective effects on functions while controlling the blood pressure. However, neural mechanism underlying dual attenuating effect of acupuncture remains unclear. In this study, we investigated electroacupuncture (EA) and manual (MA) functional activity brain regions spontaneously hypertensive rats (SHRs) by through resting-state magnetic resonance imaging (rs-fMRI). We also...
Abstract Background Ankle-foot orthoses (AFO) can improve gait posture and walking ability in post-stroke patients. However, the effect of AFO on parameters patients according to Brunnstrom stage stroke recovery lower limbs remains unclear. The study aimed investigate whether with different stages benefit from wearing AFO. Methods Twenty-five participants included 18 men (50 ± 13 years) 7 women (60 15 years). were divided based III or IV limbs. All underwent timed up go (TUG) test using a...
1,25-dihydroxyvitamin D
To observe the effects of acupuncture manipulations on blood pressure and brain function in spontaneously hypertensive rats elucidate anti-hypertensive effect manipulations' central mechanism. This study used twirling reinforcing, reducing, uniform reinforcing-reducing to act bilateral TaiChong point rats. The depth was 1.5-2 mm, twisting performed at a frequency 60 times/min within ±360° for 3 min, followed by needle being retained 17 min. Functional magnetic resonance imaging end...
A risk association between membranous nephropathy (MN) and lung cancer is reported, but traditional observational studies cannot provide strong evidence of its causality. This study aimed to assess genome-wide data for a causal relationship MN using two-sample Mendelian randomization (MR) approach. Inverse-variance weighted, MR Egger regression techniques were used determine the genetic variants from cohorts patients. Independent with significance (P < 5×10-8) direction chance. Sensitivity...
Hypertension affects multiple organs in the body during development of disease. The antihypertensive effect acupuncture has been confirmed. How protective electroacupuncture on renal cortex spontaneously hypertensive rat (SHR) is achieved not yet determined. purpose this study was to understand impact blood pressure SHRs and metabolites cortex, looking for potential differential then proceeding next step exploratory research. experimental animals were divided into four groups: control group,...
Membranous nephropathy (MN) is an autoimmune glomerular disease that predominantly mediated by immune complex deposition and complement activation. The aim of this study was to identify key biomarkers MN investigate their association with immune-related mechanisms, inflammatory cytokines, chemokines chemokine receptors (CCRs).MN cohort microarray expression data were downloaded from the GEO database. Differentially expressed genes (DEGs) in identified, hub determined using a protein-protein...
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a contemporary hazard to people. It been known that COVID-19 can both induce heart failure (HF) and raise risk of patient mortality. However, mechanism underlying association between HF remains unclear. The common molecular pathways were identified using bioinformatic systems biology techniques. Transcriptome analysis was performed identify differentially expressed...
Background: To observe the activation strategies of ankle muscles using surface electromyography (sEMG) during single-leg standing (SLS) and both-leg (BLS) on flat ground (FG), soft mat (SM), BOSU ball (BB) surfaces. Methods: Thirty healthy young adults participated in study. The muscle activities tibialis anterior (TA) gastrocnemius medial (GM) were measured three surfaces SLS BLS. Electromyographic evaluations TA GM recorded maximum voluntary isometric contractions (MVIC). Muscle was...
Acupuncture can reduce blood pressure, heart rate (HR), and ameliorate cardiac damage by modulating the excitability of sympathetic nervous system, but exact mechanism this effect remains unclear. This study investigated potential mechanisms acupuncture in treatment hypertension. Spontaneously hypertensive rats (SHR) were used as hypertension model with Wistar–Kyoto control. Manual acupuncture, electroacupuncture, metoprolol interventions. Systolic diastolic pressure (SBP, DBP) plus HR...
Chinese Herbal Medicines (CHMs), as an important and integral part of a larger system medicine practiced in China, called Traditional Medicine (TCM), have been used stroke therapy for centuries. A large body studies suggest that some herbs can help reverse cognitive impairment patients, while whether these also exert therapeutic benefits Alzheimer's disease remains to be seen.To address this issue, we selected four types CHMs are commonly prescribed treatment clinical practice, namely...
Abstract Background Corona Virus Disease 2019(COVID-19) has put human health and medical resources under strain since 2019. However, it’s still equivocal whether ulcerative colitis (UC) COVID-19 have a bidirectional causal relationship, so we attempted to clarify this issue using two-sample mendelian randomization (two-sample MR) analysis. Methods To explore the relationship between COVID-19, obtained summary statistics from GWAS database used single nucleotide polymorphisms (SNPs) as...
Autoimmune encephalitis, a class of is clinically characterized by multifocal or diffuse brain injury, including aberrant mental behavior, convulsions, and near-event memory impairment. In this article, we describe female patient with autoimmune encephalitis who tested positive for leucine-rich glioma inactivated 1 (LGI1) antibodies had hippocampal inflammatory edema in the lesion area. During first 3 months her illness, primarily experienced loss, onset rigid twitching extremities that...