A5033501824- Pharmacological Effects of Natural Compounds
- Inflammatory Bowel Disease
- Gut microbiota and health
- Berberine and alkaloids research
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Oral health in cancer treatment
- Immune cells in cancer
- Antioxidant Activity and Oxidative Stress
- Flavonoids in Medical Research
- Lipid metabolism and biosynthesis
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Neutropenia and Cancer Infections
- Mental Health Research Topics
- Helicobacter pylori-related gastroenterology studies
- Natural product bioactivities and synthesis
- Functional Brain Connectivity Studies
- Gout, Hyperuricemia, Uric Acid
- Cholesterol and Lipid Metabolism
- Cancer therapeutics and mechanisms
- Traditional Chinese Medicine Analysis
- Radiomics and Machine Learning in Medical Imaging
- Drug-Induced Hepatotoxicity and Protection
- IL-33, ST2, and ILC Pathways
Guangzhou University of Chinese Medicine
2013-2025
China Southern Power Grid (China)
2025
Sichuan University
2010-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
West China Hospital of Sichuan University
2010-2025
Fourth Affiliated Hospital of Guangxi Medical University
2023-2025
Beijing Institute of Technology
2023
Guangxi University of Chinese Medicine
2015-2021
Guangzhou University
2021
Weatherford College
2020
Abstract Treatment‐refractory depression (TRD) represents a large proportion of the depressive population, yet has seldom been investigated using advanced imaging techniques. To characterize brain dysfunction in TRD, we performed resting‐state functional MRI (rs‐fMRI) on 22 TRD patients, along with 26 matched healthy subjects and patients who were depressed but not treatment‐refractory (NDD) as comparison groups. Results analyzed data‐driven approach known Regional Homogeneity (ReHo)...
Huangqin decoction (HQD), a classical traditional Chinese medicinal formula, has been commonly used to treat gastrointestinal diseases for thousands of years. We investigated the anti-inflammatory effects and underlying mechanisms HQD on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC).Experimental mice were given 3% DSS, (2.275, 4.55, 9.1 g/kg), or mesalazine (ME, 200 mg/kg) orally 7 days. Body weight loss, disease activity index (DAI), colon length, histology, levels...
Modified Pulsatilla decoction (PD), a PD with licorice and ejiao, is classic Traditional Chinese Medicine formula significant efficacy in treating intestinal mucositis (IM) induced by tumor therapy. However, its specific molecular biological mechanisms remain unclear. To investigate the therapeutic effect mechanism of modified IM. This study used an IM mouse model established using 5-fluorouracil injections to effects (3, 6, 12 g/kg) The primary chemical components were identified liquid...
Bruguiera gymnorrhiza (BG), a medicinal mangrove, and its fruit (a food material), have traditionally been used to treat diarrhea (also known as ulcerative colitis) in folk medicine. However, the mechanism of action against colitis remains ambiguous. This study aimed investigate potential efficacy BGF on experimental colitis. Colitis was induced by oral intake dextran sulfate sodium (DSS) treated with aqueous extract (25, 50 100 mg/kg) for week. The disease activity index (DAI), colon length...
Pogostemonis Herba, known as “Guang-Huo-Xiang” in Chinese, has been widely used the treatment of gastrointestinal dysfunction. Pogostone is one major constituents Herba. The aim was to scientifically evaluate possible gastroprotective effect and underlying mechanisms pogostone against indomethacin-induced gastric ulcer rats. Rats were orally treated with vehicle, lansoprazole (30 mg/kg) or (10, 20 40 subsequently exposed acute lesions induced by indomethacin. Gross evaluation, histological...
This study was designed to investigate the relationship between plasma lipid profile and acne. Acne patients (n = 181) healthy volunteers 130) matched in terms of both age sex were enrolled. Plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol, low-density (LDL-C) (LP)(a) levels measured. TC, LDL-C LP(a) male female with severe acne significantly higher than control group (P < 0.05). TG moderate mild, The constituent ratio TG, over normal range group. In...
Palmatine (PAL) is an isoquinoline alkaloid derived from Fibraureae caulis Pierre that has been used to relieve inflammatory diseases like ulcerative colitis (UC). The metabolites of PAL were believed contribute significantly its outstanding biological activities. 8-Oxypalmatine (OPAL), a liver-mediated oxidative metabolite PAL, firstly identified in the present work. We aimed comparatively investigate potential effect and mechanism OPAL on dextran sodium sulfate (DSS)-induced Balb/c mice....
Berberine (BBR), a major active constituent of Rhizoma coptidis, was reported to exert beneficial effects on intestinal mucositis (IM) induced by 5-fluorouracil (5-FU). However, the bioavailability BBR is extremely low, and its metabolites were perceived contribute prominent pharmacological activities. Oxyberberine (OBB) gut metabolite BBR, which has been have superior anti-inflammatory effect in experimental colitis. against 5-FU-induced IM mice not yet investigated. Hence, purpose this...
This paper explores the challenges of detecting wiring anomalies in three-phase, four-wire energy metering devices, especially when large amounts reactive power compensation are involved. Traditional methods, such as hexagon phasor diagram technique, perform well under standard loads, but struggle to adapt new situations, over- or under-compensation. To overcome these limitations, this proposes a hybrid approach that combines mechanism-based knowledge with data-driven technologies, including...
Palmatine (PAL) and berberine are both classified as protoberberine alkaloids, derived from several traditional Chinese herbs such Coptis chinensis Franch. Phellodendron chinense Schneid. These compounds extensively used in treating dysentery colitis. PAL is one of the crucial quality markers for these plants Pharmacopoeia. A key metabolite PAL, 8-Oxypalmatine (OPAL), shows favorable anti-inflammatory activity better safety compared to though its mechanisms ulcerative colitis (UC) not fully...
A characterization of the impact natural disasters on brain survivors is critical for a better understanding posttraumatic responses and may inform development more effective early interventions. Here we report alterations in white matter microstructure soon after Wenchuan earthquake China 2008. Within 25 days earthquake, 44 healthy were recruited scanned 3T MR imaging system. The divided into two groups according to their self-rating anxiety scale (SAS) score, including SAS(+) (SAS > 55...
Previous studies have demonstrated that regulatory T cells (Tregs) are pivotal in the regulation of cell‑mediated immune responses atherosclerosis, a chronic autoimmune‑like disease. In authors' previous studies, it was amygdalin ameliorated atherosclerosis by Tregs apolipoprotein E‑deficient (ApoE‑/‑) mice. Therefore, aim present study to investigate therapeutic effect on low‑density lipoprotein (LDL) receptor deficient (LDLR‑/‑) mice, and examine its function stimulation Tregs. To...
Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic hepatic disorder worldwide. The earliest stage of NAFLD simple steatosis, which characterized by accumulation triglycerides in hepatocytes. Inhibition steatosis a potential treatment for NAFLD. Patchouli alcohol (PA) an active component Pogostemon cablin (Blanco) Benth. (Labiatae), medicinal food Asia countries and proved to possess hepatoprotective effect. This research aimed investigate effectiveness PA against...
Brucea javanica is an important Chinese folk medicine traditionally used for the treatment of dysentery (also known as inflammatory bowel diseases). oil emulsion (BJOE), most common preparation javanica, has a variety pharmacological activities. In this follow-up investigation, we endeavored to illuminate potential benefit BJOE on 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced Crohn's disease (CD) in rats and decipher mechanism action. The result illustrated that significantly reduced...