A5048620881- Berberine and alkaloids research
- Gout, Hyperuricemia, Uric Acid
- Diet, Metabolism, and Disease
- Ginseng Biological Effects and Applications
- Alkaloids: synthesis and pharmacology
- Metabolism, Diabetes, and Cancer
- Inflammasome and immune disorders
- Aerogels and thermal insulation
- Cannabis and Cannabinoid Research
- Genomics, phytochemicals, and oxidative stress
- Gut microbiota and health
- Mesoporous Materials and Catalysis
- Curcumin's Biomedical Applications
- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Osteoarthritis Treatment and Mechanisms
- Liver Disease Diagnosis and Treatment
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Biochemical effects in animals
- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Toxin Mechanisms and Immunotoxins
- Plant-based Medicinal Research
- Alcohol Consumption and Health Effects
Guangzhou University of Chinese Medicine
2020-2024
Phellodendri Chinese Cortex has long been used to treat hyperuricemia and gout. Berberine (BBR), its characteristic ingredient, also shown be effective in alleviating monosodium urate crystals-triggered gout inflammation vitro vivo . Dihydroberberine (DHB) is a hydrogenated derivative of BBR that showed improved efficacy on many metabolic disorders. However, anti-hyperuricemia effect remains underexplored. In the present work, hypouricemic renoprotective effects DHB hyperuricemic mice were...
Purpose: Gouty arthritis could be triggered by the deposition of monosodium uric acid (MSU) crystals. Palmatine (PAL), a protoberberine alkaloid, has been proven to possess compelling health-beneficial activities. In this study, we aimed explore effect PAL on LPS plus MSU crystal-stimulated gouty in vitro and vivo. Methods: PMA-differentiated THP-1 macrophages were primed with then stimulated crystal presence or absence PAL. The expression pro-inflammatory cytokines oxidative stress-related...
Palmatine (PAL) is an isoquinoline alkaloid derived from Fibraureae caulis Pierre that has been used to relieve inflammatory diseases like ulcerative colitis (UC). The metabolites of PAL were believed contribute significantly its outstanding biological activities. 8-Oxypalmatine (OPAL), a liver-mediated oxidative metabolite PAL, firstly identified in the present work. We aimed comparatively investigate potential effect and mechanism OPAL on dextran sodium sulfate (DSS)-induced Balb/c mice....
Berberine (BBR) has extremely low concentration and high tissue distribution. However, current pharmacokinetic studies predominantly focus on its in plasma, which could hardly make a comprehensive understanding of process. This study made pioneering endeavor to explore the erythrocyte-hemoglobin (Hb) self-assembly system BBR by exploring interaction with erythrocyte combination Hb. Results showed that had bioavailability (C0 = 2.833 μg/mL via intravenous administration 2.5 mg/kg Cmax 0.260...
Zishen Yuzhen Pill (ZYP) is a Chinese herbal product developed by Shenzhen TCM Hospital, which have been frequently used to treat osteoporosis (OP). This study aimed determine the major chemical components of ZYP and its prototype compounds metabolites in rat biological samples, as well explore potential effect ZYP-containing serum MC3T3-E1 cells. UPLC-Q/TOF-MS was identify components. Then, orally administered rat, samples plasma, urine, feces, bile, tissue were collected metabolites. The...
Hyperuricemia (HUA), a common metabolic disease, is treated as the second-largest disease after diabetes in China. Cortex Phellodendri (CP) one of most frequently used herbal medicines for treating gout or HUA. However, mechanism underlying anti-HUA effect CP still unrevealed. Hence, this study aimed to explore pharmacological against HUA using network pharmacology coupled with vivo experimental validation. Active compounds and potential targets CP, well related HUA, were retrieved from...
Curcumin (CUR) possesses pronounced anti‐inflammatory and antioxidant activities. Generally, the clinical application of CUR is restricted due to its apparent unstability poor absorption, biological activities may be closely associated with metabolites. Tetrahydrocurcumin (THC) octahydrocurcumin (OHC) are two major hydrogenated metabolites appreciable potentials. Here, we comparatively explored CUR, THC, OHC in lipopolysaccharide‐ (LPS‐) induced RAW264.7 macrophages. The results revealed...
Coptisine (COP) is a bioactive isoquinoline alkaloid derived from Coptis Chinemsis Franch, which traditionally applied for the management of colitis. However, blood concentration COP was extremely low, and its gut microbiota-mediated metabolites were thought to contribute prominent bioactivities. To comparatively elucidate protective effect underlying mechanism novel microbiota metabolite (8-oxocoptisine, OCOP) against colitis, we used dextran sulfate sodium (DSS) induce colitis in mice....
Propose: Berberine (BBR) is extensively studied as an outstanding anti-hyperuricemia drug. However, the clinical application of BBR was limited due to its poor absorption and low bioavailability. Therefore, there urgent necessity find a novel drug formulation address issues in application. Methods: Herein, we conducted solubility, characterization experiments verify whether sodium taurocholate (STC) self-assembled nanoparticles (STC@BBR-SANPs) could form. Furthermore, proceeded release...
Berberine (BBR) is the primary active component of Phellodendri Chinensis Cortex (PCC), which has been traditionally used to treat inflammatory diseases. However, discrepancy between its low bioavailability and significant therapeutic effect remains obscure. The purpose this study was explore previously unsolved enigma BBR appreciable anti-inflammatory reveal action mechanism PCC.The quantitative analysis metabolite oxyberberine (OBB) in blood tissues performed using high-performance liquid...
Resorcinol-formaldehyde aerogel (RFa) is a unique nanomaterial composed of polymer nanoparticles with three-dimensional network structure. Our previous studies have demonstrated its application in the separation and purification alkaloids, we are exploring potential as drug delivery carrier. Therefore, it necessary to comprehensively understand vivo toxicity profile RFa evaluate oral biosafety. In this work, systematically evaluated acute subchronic both male female Kunming mice. During...